7JSH


Conserved Protein Domain Family
Parvo_NS1
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pfam01057: Parvo_NS1 
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Parvovirus non-structural protein NS1
This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.
Links
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Statistics
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PSSM-Id: 426020
Aligned: 25 rows
Threshold Bit Score: 169.41
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7JSH_A   219 R----------------------SKTSARY--------------MELVGWLV--------DKGITSEKQWIQEDqasyiS 254
Q65023   281 TdqtdsatsktgtsliwkscatkVTSKKEVanpvqqpskklysaQNTLDALF--------NVGCFTPEDMIIKQsdkylE 352 Aleutian mink disea...
Q7TD16   237 EskkhkgsnnqqniqkqssttaiASGHDIVdgeldg--rsesnrETAYYTFV--------LHKNNCKEDWRYIA------ 300 Aedes albopictus C6...
P05842   288 NhkevfqadkqardefftsfvhiGNVHSLIggig-------lgtKNLVEEHVlgkplygmGKRKSTEKDWAKIK-----R 355 Bombyx mori densovirus
Q993M6     2 Q----------------------TRKEVSI--------------KTTLKELV--------HKRVTSPEDWMMMQpdsyiE 37  Autonomous rat parv...
Q00683   225 K--------------------------SKF--------------LGTIEWLS--------DLGIVTEDAWIRRDirsymQ 256 Human herpesvirus 6...
Q9DW64    55 E-----------------------SPVDKL--------------PKMVATLI--------EYGIVNENTWCLEEfesylE 89  Rat cytomegalovirus...
Q89621     1 M----------------------SRESERY--------------WTLVHALI--------DRGVVSREQWQMVDpaqyqF 36  Fowl aviadenovirus 1
Q9YYR9     1 M----------------------SGSRDRY--------------WSLVESLI--------NRGIVTRQQWYFNDrseygY 36  Fowl aviadenovirus 8
AMB36744   1 M------------------------ASDRY--------------WDLVNSLI--------NRGIVTREQWQSADlaeyrR 34 

7JSH_A   255 FNAASNSRSQIKAALDNAGKIMSLTKTAPDYLVGQQPVe-----DISSNRIYKILELNGYDPQYAASVFLGWATKKFGKR 329
Q65023   353 LSLEPNGPQKINTLLHMNQVKTSTMMTAFDCIIKFNEE-------EDDKPLLATIKDMGLNEQYLKKVLCTILTKQGGKR 425 Aleutian mink disea...
Q7TD16   301 ----------TTRAKQAPSFITFDHGNHIHILFSSSNTgg--nsTRVRTRITKFLSATSAGSAEAT----ITFSKVKFLR 364 Aedes albopictus C6...
P05842   356 INRARAARR--ENQENQPDIREFGHVAGQNINADQEVNla--dfPDFLQDFDAEAGPSGTQPVETAQQSPPTMSEDIQPM 431 Bombyx mori densovirus
Q993M6    38 MMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETsklanfSMASTRTCRIFAEHGWNYIKVCHAICCVLNRQGGKR 117 Autonomous rat parv...
Q00683   257 LLTLTHGDVLIHRALSIAKKRIRATRKAIDFIAHIDTDf-----QIYENPVYQLFCLQSFDPILAGTILYQWLSHRGGKK 331 Human herpesvirus 6...
Q9DW64    90 VQSDPVKRARARKAISVARRYLGTRESPLRYVIKGDGTtv--arDICDNPTYRLIRTHNLNPRVVAGVLWAFLRSRHTPK 167 Rat cytomegalovirus...
Q89621    37 YHRSKQRGFKVRHILRDVIRHMCWSRTLLDYMSSASTPsp---dDVLRNPLYQLLLCNGYNPAVVGTALIRWAGHQ-SNR 112 Fowl aviadenovirus 1
Q9YYR9    37 YTKRYRGAMKLSNLFRDVRRHMFWTKCLADYMLTPETDf----lQIEENPFYSVFSKNGYDPALVGSMLLAWAARQ-SKR 111 Fowl aviadenovirus 8
AMB36744  35 YSKGYVRGFSVRKVLRDVIKHMCWTKVLGDYLVCPVVCq----dDIHLNPFYVILMKNGYNPRVVGTILHKWSMLT-SNK 109

7JSH_A   330 NTIWLF-------------------------GPATTGKTNIAE-------------------AIAHTVPFYGCv--NWTN 363
Q65023   426 GCIWFY-------------------------GPGGTGKTLLAS-------------------LICKATVNYGMv--TTSN 459 Aleutian mink disea...
Q7TD16   365 NYILYCiry--------------------giETVNIYGNKIQQ-------------------QLTEAMDTFKVl-fENRD 404 Aedes albopictus C6...
P05842   432 ETVGATdtgggaqvdprtggqaaggsemgagGSANDGREDIFSgapqpnqhhtlvygksyhfTITKWFTEFRHl--ATTN 509 Bombyx mori densovirus
Q993M6   118 NTVLFH-------------------------GPASTGKSIIAQ-------------------AIAQAVGNVGCy--NAAN 151 Autonomous rat parv...
Q00683   332 NTVSFI-------------------------GPPGCGKSMLTG-------------------AILENIPLHGIlhgSLNT 367 Human herpesvirus 6...
Q9DW64   168 NCLWLY-------------------------GEADTGALDLAN-------------------AIMACVPLTGIl--VGTP 201 Rat cytomegalovirus...
Q89621   113 NTVWIR-------------------------GTPMSGAPYLAQ-------------------AIAYCSPLVGSv--DWRN 146 Fowl aviadenovirus 1
Q9YYR9   112 NTVWIR-------------------------GAPVTGAPYLAE-------------------AIAYCCPLMTCv--DWRN 145 Fowl aviadenovirus 8
AMB36744 110 NTVWVW-------------------------GGAETGGPYLAE-------------------AIAYTSPVVGCv--DWRN 143

7JSH_A   364 ENFPFNDCVDKMVI-WWEEGKMTAKVVESAKAILGGSKVRVDqkcks-----saqiDPTPVIVTSNTNMCAV-IDgNSTT 436
Q65023   460 PNFPWTDCGNRNII-WAEECGNLGNWVEDFKAITGGGDVKVDtknkq-----pqsiKGC-VIVTSNTNITKV-TVgCVET 531 Aleutian mink disea...
Q7TD16   405 PNDVILDAGCKL---YHEEKKDYQQKRCGQRKQQNLTDIILDkikdk----kittaQQWENIIEPEFKIQLM-KEfGLNV 476 Aedes albopictus C6...
P05842   510 SGYYAQQRFKHIHGiPWERLLMYVSEGELLRMFRDYTSLKVE--------------EVVCEVYSLGVRLPFV-TSaTTSS 574 Bombyx mori densovirus
Q993M6   152 VNFPFNDCTNKNLI-WVEEAGNFGQQVNQFKAICSGQTIRIDqkgkg-----skqiEPTPVIMTTNENITVV-RIgCEER 224 Autonomous rat parv...
Q00683   368 KNL---RAYGQVLVlWWKDISINFDNFNIIKSLLGGQKIIFPinend-----hvqiGPCPIIATSCVDIRSM-VHsN--- 435 Human herpesvirus 6...
Q9DW64   202 TQEDLAACVDKLLI-WWRDPPENVLVSDTYRSLLAGMLLKVrakev------tkslRKTPVLVTTGRELVRT-EDgS--- 270 Rat cytomegalovirus...
Q89621   147 KSNPFEGCPDSLVF-WWDGGYVYDCCVGLVKQVFRGEHVILPpeglrgp-npcselFRTPVLMYSQADICMTrLRsGELS 224 Fowl aviadenovirus 1
Q9YYR9   146 KQNPFEKGFESLLF-WWDGGHVPHRCVALCRQVFRGENVMFPredgq-----mselVRTPVLLYSEHDACRTlVKwGVFS 219 Fowl aviadenovirus 8
AMB36744 144 RANPFARNYNCLVY-WLDGGLFPESAIGLCEQVLRGEGTMVEveegatgerrwreiNRTPVLISTSHDVTLTyVKyGQTC 222

7JSH_A   437 FEHQQP------------LQDRMFKFELTRRLDHD----FGKVTKQEVKDFF-RWAKD--------HVVEVEHEFY 487
Q65023   532 NAHAEP------------LKQRMIKIRCMKTINPK-----TKITPGMLKRWLnTWDRQ---------PIQLSHEMP 581 Aleutian mink disease v...
Q7TD16   477 DSYVQRivriertriqqlIKSKTLTEIMVEILNEEyiknFTPGEDNSKLQNIiQWIEY------------MFKENN 540 Aedes albopictus C6/36 ...
P05842   575 VANANAqypidvfhfdeaYETNYGINNVADIINKAlgteWKNATRPTAPVTT-AWSEQfpnisassTSRDINNPVI 649 Bombyx mori densovirus
Q993M6   225 PEHTQP------------IRDRMLNIHLTRTLPGD----FGLVDKHEWPLIC-AWLVK--------NGYQSTMACY 275 Autonomous rat parvovir...
Q00683   436 -LHKIN------------LSQRVYNFTFDKVIPRN----FPVIQKDDINQFL-FWARN--------RSINCFIDYT 485 Human herpesvirus 6 (st...
Q9DW64   271 -PNAVH------------LKSKMWKVCLAGTVSQD----MLGLRSRDVREFL-QWLEM--------IEMGETASMN 320 Rat cytomegalovirus Maa...
Q89621   225 AEHAVG------------LRDCMYLIRLTEDFDCA-----GGISCADVKQFV-AWSREh------pGEVRETHELK 276 Fowl aviadenovirus 1
Q9YYR9   220 DEFSDG------------LRNSMYCLDLSAPMEGA-----QCVTCADARAFF-TWAYP----------RRMDFDCF 267 Fowl aviadenovirus 8
AMB36744 223 KDHTNS------------LRSAMYVLRLTERVEPG-----FVITCNDARKFV-TWASN---------NPHINAEDM 271
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