5MR4,5MR4,6GL7,4UX8,2GH0,5VZ4,5VZ4


Conserved Protein Domain Family
GDNF

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pfam02351: GDNF 
GDNF/GAS1 domain
This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.
Statistics
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PSSM-Id: 460537
Aligned: 117 rows
Threshold Bit Score: 35.9691
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MR4_C        251 CLDLRGVCRTDHLCRSRLADFHANCRASY--QTVTSCPadnYQACLGSYagmigfdmtPNYVDSSPTgiVVSPWCSCRGS 328
AAI25919      131 CTEARKQCEKDPECKTAMLDYLYHCRKLFggNRCS-------DDCRTLI---------ANMRSNPKA--QLLDTCVCDG- 191
XP_006014263  131 CTQARRECEKELKCSMSLSKYLSHCGNLFngLQCT-------ESCKAVI---------EDMLSVPKA--VLLNECVCDG- 191
XP_011492102  114 CMEARQRCEENPVCHTSLAAYLAHCGQLFngRRCS-------SKCKATI---------QQMLSIPNG--ELLNQCIC--D 173
EKC42622      121 CLTAHLICDTDSTCAAALNYYHSLCGNLKdaGWCS-------ERCNESI---------NILYQTKYA--MKLQKCKCDKT 182
XP_012551939  112 CSLSQLICLADAQCSTALQYYHHLCRSMFrgRKCS-------KKCINSI---------EILRKQEKA--AALTVCQCDG- 172
40_pfamImport   1 CEVAQWICSADTLCSTALMYYNMNCRSMFagRKCS-------PRCKNSI---------EILRRQEKA--AKLDSCVCNG- 61 
XP_008195285  111 CRVAQWICAADALCSTALEYYNHYCRAMFhgKKCT-------PRCNNSI---------SILRRQEKA--AKLTMCKCDG- 171
XP_025198115   75 CLLARSLCNEDPSCFKIINLIPSLCGNEI--VSCSTTT---VIKCRAAL-----------KTLQAFP--FFKPTCLCREP 136 Melanaphis sac...
XP_005994143  120 CTEARQRCEDEAACQGMLTSYLANCGQLFngRRCT-------AKCQDTI---------EHMLSTPSG--ALLNKCICDG- 180 coelacanth
5MR4_C        329 GNMEEECEKFLRDFTENPC 347
AAI25919      192 -NERTTCEYVKFSM--KNL 207
XP_006014263  192 -LERPICESLKENM---AK 206
XP_011492102  174 GVERPFCEVVKENM---SK 189
EKC42622      183 -TDDFNCFELQQNTDYCLK 200
XP_012551939  173 -TEDYDCPTMQENL----A 186
40_pfamImport  62 -REDYNCNTIRTNM----E 75 
XP_008195285  172 -LEDYDCPAIQRNM---EK 186
XP_025198115  137 -KIDYECNSFRNFLFDHPC 154 Melanaphis sacchari
XP_005994143  181 -VERPFCEVMKDNM---ER 195 coelacanth
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