1WF6


Conserved Protein Domain Family
BRCT_TopBP1_rpt3
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cd17718: BRCT_TopBP1_rpt3 
third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain.
Links
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Statistics
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PSSM-Id: 349350
Aligned: 26 rows
Threshold Bit Score: 102.289
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [CS]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      #  
1WF6_A         35 QAPEDLLDGCRIYLCGFSgRKLDKLRRLINSGGGVRFNQLnEDVTHVIVGDy--DDELKQFWNKsa--hRPHVVGaKWLL 110  human
AAQ22476      392 KKAGAFLDGCCVYLSGFRsEEREKLNRVLNTGGATRYDEAnEGISHIIVGQl--DDAEYRQWQRdglmgSVHVVRlDWLL 469  fruit fly
XP_002109490  315 EHSSFFLDGCKILLSGFNeIQQSQLQSVINSGGGTRFNTLeDSVTHVVISEd--SLWNPTDLKAlk--sQPFVVSvRWLI 390  Trichoplax ad...
XP_002405192  340 SHCGQFLDGCCVVLWGFApEKLDKMRRVINACGGVRFNEYaEEVTHVVVAEgasVSQLNKAIAKqg--gFPYLVSpQWFA 417  black-legged ...
XP_004210149  365 EHSSTYFDGFKIYLCNITgALFDICRKIINNGGGFRLNNFtDSITHIVFSQs--APKELTNYIKelsnhLPYIVSpLWLI 442  Hydra vulgaris
XP_014283344  371 KAAGPFLDGCKIYLSGFSpQECEKLKRLINSGGATLFTSLsDNLSHVVVGDf--SAADAKELANli--aRPHVVKlQWLI 446  brown marmora...
XP_018896229  395 KRSSGFLDGCKVFLSGFSpSEEDLLRKILNAGGAVRYSELsDLVTHVVVGAs--LPHLTNTLANlr--tKPYVVTlDWIK 470  Bemisia tabaci
XP_001751497  311 EKDSMYLSGCRVFLTGFNaAEMKKQVNLVLAGGGTRHMEMnDTITHVILGSn-sAECGMKEIRQlamwgAVYIVQpAWLE 389  Physcomitrell...
AAG29194      326 EDNDLYLSDCRIFLLGFEaSEMRKLAKLVRRGGGSRYMLLnERMTHIVVGTp--SEREARSVAAs---gVIQVVIpSWLE 400  thale cress
GAQ80806      344 DDDKLFLSSCRLYFSGMTrEELQEAMGIMRASGATRYALLdERATHVVLGDs--PDCDLTEVRKldlegIVEVVRlSWLR 421  Klebsormidium...

Feature 1          #     
1WF6_A        111 ECFSKGY 117  human
AAQ22476      470 ESIRAGR 476  fruit fly
XP_002109490  391 DSSKNGI 397  Trichoplax adhaerens
XP_002405192  418 ESSALGA 424  black-legged tick
XP_004210149  443 DSAKNNQ 449  Hydra vulgaris
XP_014283344  447 QCLKERR 453  brown marmorated stink bug
XP_018896229  471 MSIQQQH 477  Bemisia tabaci
XP_001751497  390 ECTRQRR 396  Physcomitrella patens subsp. patens
AAG29194      401 DCDREKK 407  thale cress
GAQ80806      422 ACLQYRK 428  Klebsormidium nitens

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