2YWR,3DA8,3P9X,1ZLY,1CDE,3KCQ


Conserved Protein Domain Family
FMT_core_GART

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cd08645: FMT_core_GART 
Click on image for an interactive view with Cn3D
Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
Phosphoribosylglycinamide formyltransferase, also known as GAR transformylase or GART, is an essential enzyme that catalyzes the third step in de novo purine biosynthesis. This enzyme uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide. In prokaryotes, GART is a single domain protein but in most eukaryotes it is the C-terminal portion of a large multifunctional protein which also contains GAR synthetase and aminoimidazole ribonucleotide synthetase activities.
Statistics
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PSSM-Id: 187714
Aligned: 169 rows
Threshold Bit Score: 199.15
Created: 12-Feb-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1ZLY_A; Human glycinamide ribonucleotide transformylase, N-terminal GART domain binds the inhibitor hydroxyacetamide ribonucleotide and the cosubstrate 10-formyl-5,8, dideazafolate (10-CHO-DDF).
  • Structure:1CDE_C, Escherichia coli glycinamide ribonucleotide transformylase, binds the substrate glycinamide ribonucleotide and a folate inhibitor. Defined at a 4A distance.
  • Citation:PMID 1631098

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #    ###                                                                   
2YWR_A         3 KIGVLVSGRGSNLQAIIDAIEsgk-vnaSIELVISDNPkayAIERCKKHNVECKVIQrkefpskkefEERXALELKKKGV 81  Aquifex aeolicus
1ZLY_A         2 RVAVLISGTGSNLQALIDSTRepn-ssaQIDIVISNKAavaGLDKAERAGIPTRVINhklyknrvefDSAIDLVLEEFSI 80  human
ZP_05617250    3 KIAVLVSGGGTDLQSILDAIEdkkltdcKVSYIVADREc-rALERAKKYNIPFCILK----------KGELNQFFQEKDM 71  Fusobacterium s...
NP_561601      3 KIAVLASGSGSNLQSILDNINngn-ikgEVSLVIGSKEdifALERAEKQGIKTSVVSkkef--gdktSDEILRLAKENNI 79  Clostridium per...
YP_003305426   3 KIAVLVSGSGTNLRKILENNI-------DVAVIISDRKc-lSEDIAKEYNIPYFELErk------niSNKILDILNDIDV 68  Streptobacillus...
ZP_03850045    3 NIVVLVSGSGTNLQRIIDTIDsgeiqnaKVTLVVADREc-fGLERAKNHNIENILIPrg------knFSSELAKVIPENT 75  Chryseobacteriu...
YP_001209133   3 QICVLISGGGSNLAALIAAIScyq-wniRINSVIADRTc-aGKQHAIAAQIPFHLVDrtld---kttFAEQLIATVPPET 77  Dichelobacter n...
ZP_05704121    3 SLVVLISGSGSNLKALLDAVArge-iraQVKAVIADRDc-aGRQHAEAAGVPFVLLNrk------taDFAAALDAAVPDC 74  Cardiobacterium...
NP_393561      7 NICILVSGTGTTLQAVIDAIAggk-ldaRISEVIADREc-mAADRARKAGVKTVVVRrgr-----nfQSDLMKEMENSCA 79  Thermoplasma ac...
NP_811795      5 NIVVCASGGGGNFRSLIKYQCdy---gyHISLLIVDREc-pAIKIAKENGISYSVLEkkvl---gksFFEEFEKIVPIDT 77  Bacteroides the...
Feature 1            ########    #        ####            #                   # ##  ##           
2YWR_A        82 ELVVLAGFXRILSHNFLKyfpNKVINIHPSLIPAF-----QGLHAQKQAVEFGvkFSGCTVHIVDESVDAGPVIVQAVVP 156 Aquifex aeolicus
1ZLY_A        81 DIVCLAGFMRILSGPFVQkwnGKMLNIHPSLLPSF-----KGSNAHEQALETGvtVTGCTVHFVAEDVDAGQIILQEAVP 155 human
ZP_05617250   72 DLIVLAGYLSILPSDFLQrweKKIINIHPSLLPKFggkgmHGNHVHKAVLAAKeeKSGCTVHYVTEEIDGGEIILQREVP 151 Fusobacterium s...
NP_561601     80 HLIVLAGYLSILKGKLLEeygNRIINIHPSLIPSFcgnkmYGINVHKAAIEKGvkFSGCTVHFVNDEVDGGAIIAQEIVE 159 Clostridium per...
YP_003305426  69 ELIVLAGFLSIIKGDILDkyeNRIINIHPSLIPKYsgvgmYGMRIHEKVFENKetISGTTIHYVTKGVDEGKIIRQEIVD 148 Streptobacillus...
ZP_03850045   76 DLIVLAGFLSILKSEFCEnwnGKIINIHPALLPKFggkgmWGMNVHNAVIEAKevESGATVHFVTPGIDEGEAILQKSFE 155 Chryseobacteriu...
YP_001209133  78 ELIVLAGFLSIIPPSLLHh-fPRIINIHPSLLPKFggagmYGLKVHQAVIAAGerESGCTVHWVNQEIDGGAILAQNRVS 156 Dichelobacter n...
ZP_05704121   75 DLVVLAGFLSIIPPALVArfpHRMVNLHPSLLPKFggagmYGLRVHQAVLAAGerESGCSVHWVDTGIDSGAVIAQAQVP 154 Cardiobacterium...
NP_393561     80 DFFLLAGFLSILDAGIIErfrNRIINTHPSLLPCFggkgfYGMRVHEAVIESGakFSGCTVHFVTEEIDGGPIILQRVLQ 159 Thermoplasma ac...
NP_811795     78 NLIVLAGFLPIIPKWICEkweRKIINIHPSLLPKYggkgmYGVKVQEAILRNHekYAGCTVHYVDSEIDTGEIIAQKKIL 157 Bacteroides the...
Feature 1                         #           
2YWR_A       157 VLpeDDENTLADRILKWEHKILPQTVQWF 185 Aquifex aeolicus
1ZLY_A       156 VKrgDTVATLSERVKLAEHKIFPAALQLV 184 human
ZP_05617250  152 VYaeDTVELLQERVLEQEHILLPEAIQKI 180 Fusobacterium sp. 3_1_5R
NP_561601    160 VNfeDTPESLQKKVLEKEHILLPRIVKYL 188 Clostridium perfringens str. 13
YP_003305426 149 VReaKSPEEIQKLILEREWEIYPKTIKEI 177 Streptobacillus moniliformis DSM 12112
ZP_03850045  156 VTadDTPETLAQKVHQIEYEIFPVAINKV 184 Chryseobacterium gleum ATCC 35910
YP_001209133 157 VFpdDTPEQLQQRILAYEHQLLPATIARL 185 Dichelobacter nodosus VCS1703A
ZP_05704121  155 VLadDTPQTLQARIAPEEHRLLVTTVARL 183 Cardiobacterium hominis ATCC 15826
NP_393561    160 VDdvDTPETLENKIHAIEHSAVLQALNII 188 Thermoplasma acidophilum DSM 1728
NP_811795    158 VMenESAWELGGRVFNEEIILLPLAIKHI 186 Bacteroides thetaiotaomicron VPI-5482

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