1YZ4


Conserved Protein Domain Family
DSP_DUSP15
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cd14582: DSP_DUSP15 
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dual specificity phosphatase domain of dual specificity protein phosphatase 15
Dual specificity protein phosphatase 15 (DUSP15), also called Vaccinia virus VH1-related dual-specific protein phosphatase Y (VHY) or VH1-related member Y, functions as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). DUSP15 is an atypical DUSP; it contains the catalytic dual specificity phosphatase domain but lacks the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. It is highly expressed in the testis and is located in the plasma membrane in a myristoylation-dependent manner. It may be involved in the regulation of meiotic signal transduction in testis cells. It is also expressed in the brain and has been identified as a regulator of oligodendrocyte differentiation. DUSP15 contains an N-terminal catalytic dual specificity phosphatase domain and a short C-terminal tail.
Links
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Statistics
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PSSM-Id: 350430
Aligned: 4 rows
Threshold Bit Score: 313.04
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:x x C x x x x x RClick to see conserved feature residue pattern help
Evidence:
  • Structure:1YZ4: Human DUSP15 binds a sulfate ion in the active site; contacts at 4A
  • Comment:also based on the structures of some DUSP family members with bound phosphorylated substrates (peptide and non-peptide)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #                                        #                       
1YZ4_A         4 MGNGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEvpIKKHFKECINFIHCCRLN 83  human
XP_417451      1 MGNGMSKILPGLYLGNFIDAKDLEQLSRNKITHIVSIHESPQPLLQDITYLRIPLPDTPEasIKKHFKECISFIHQCRLQ 80  chicken
Q8R4V2         1 MGNGMTKVLPGLYLGNFIDAKDPDQLGRNKITHIISIHESPQPLLQDITYLRISVSDTPEvpIKKHFKECVHFIHSCRLN 80  house mouse
XP_007062550   1 MGNGMNKVLPGLYLGNFIDAKDLEQLSRNKITHIISIHESPQPLLQEMTYLRIPLPDTPEanIKKHFKECISFIHYCRLH 80  green sea turtle

Feature 1               #######                                                    
1YZ4_A        84 GGNCLVHSFAGISRSTTIVTAYVMTVTglgwRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKL 149 human
XP_417451     81 GGNCLVHCLAGISRSTTIVVAYVMAVTemssQEVLEAIRSVRPVANPNPGFKQQLEEFSGSAARKM 146 chicken
Q8R4V2        81 GGNCLVHCFAGISRSTTIVIAYVMTVTglgwQEVLEAIKASRPIANPNPGFRQQLEEFGWANSQKL 146 house mouse
XP_007062550  81 GGNCLVHCLAGISRSTTIVVAYVMAVTelswQEVLQAVRAVRPIANPNPGFKQQLEVFGHGPARKI 146 green sea turtle

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