1X63


Conserved Protein Domain Family
LIM2_FHL1

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cd09424: LIM2_FHL1 
Click on image for an interactive view with Cn3D
The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
The second LIM domain of Four and a half LIM domains protein 1 (FHL1): FHL1 is heavily expressed in skeletal and cardiac muscles. It plays important roles in muscle growth, differentiation, and sarcomere assembly by acting as a modulator of transcription factors. Defects in FHL1 gene are responsible for a number of Muscular dystrophy-like muscle disorders. It has been detected that FHL1 binds to Myosin-binding protein C, regulating myosin filament formation and sarcomere assembly. LIM domains are 50-60 amino acids in size and share two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes.
Statistics
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PSSM-Id: 188808
Aligned: 9 rows
Threshold Bit Score: 91.7469
Created: 21-Jul-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:1X63_A: Human Skeletal Muscle Lim Protein 1 LIM2 domain binds Zn
  • Comment: The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #  #                  #  #  #  #                 #  #     
1X63_A        18 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTgsFFPKGEDFYCVTCHETKF 75   human
CAG11730     101 CHGCYKSIPAGTETVEYKGNSWHDDCFTCYSCKRPIGTqsFLSKGSDVYCSPCYDKKF 158  spotted green pufferfish
AAI59223     101 CHGCYKPILPGTENVEYKGNSWHDECFKCYQCQKPIGNksFITKNNNVYCSPCHEKKF 158  zebrafish
NP_001013190 100 CKGCLKDIKQGEQSVEYKGTIWHKDCFVCSNCKEVIGTktFFPKDEGFYCVACYDILF 157  Norway rat
NP_001007288 118 CQGCYKVITPGCKNVEYKHKVWHEECFTCFECKQPIRTqsFLTKGDDMYCTPCHEKKF 175  zebrafish
ACM08815     101 CHACYKAILAGSENVEYKGNVWHEDCFTCYQCKKPIRSqsFLTKGTDIYCGPCHEKKF 158  Atlantic salmon
NP_001087017 101 CSGCYKQIQPGGQNVEYKGSAWHEECFTCSNCKQAIGAgsFFPKGTDVYCVTCHEQKF 158  African clawed frog
XP_002191091 118 CKGCFKPIIAGDQNVEYKKMVWHKDCFTCSQCKQVIGSgsFFPKGDDFYCVSCHEHKF 175  zebra finch
AAC06327     100 CKGCLKDIEEGDHNVEYKGSIWHKNCFVCTNCKDIIGTknFFPKDEGFYCVTCYDALF 157  house mouse

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