2COZ,2CP5,2CP6,1WHG,2CP0,1WHH,2COW,1WHK,4B6M,1IXD


Conserved Protein Domain Family
CAP_GLY

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pfam01302: CAP_GLY 
CAP-Gly domain
Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.
Statistics
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PSSM-Id: 460154
Aligned: 598 rows
Threshold Bit Score: 41.2341
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2COZ_A         34 IGDR--Vl------iGNVQ--PGILRFKG--------ETS-----FAKGf-------WAGVEL----DKP---E-GNN-- 73   human
XP_005802385  105 VGTNvmVke-----edEML--MGVIRYIG--------PI------LEPDyvnpirgrFFGIEL----QKPdkgK-GKT-- 156 
EDO30311     1190 LGMR--Vlv----trTRGNvgRGVVKYVG--------SLP-----DRTDt-------YIGVEL----DSG---E-GKH-- 1233
XP_002604281  993 PGGK--I-----------S--KGSVMYVG--------HLP-----GRSEa-------YLGVEL----DSE---D-GKH-- 1027
XP_002599874   63 VEVS--Iqg-----vPTDV--PGIVRYRG--------NVP-----GFSGi------tF-GVELl---DS----K-GKGts 105 
XP_011417594  113 INDQ--Vtvavk--gqpyL--KGIIKYKG--------ELP-----GVKGi-------QFGIELl---GES---K-GKGtc 159  Pacific oyster
XP_009022371  110 ldDE--VlilkigktetnL--TGKIKYKG--------PVP-----GKDGt-------YFGVEL----NSE---FsGKGah 158 
XP_006007582  115 KGDS--VrvqissssgekV--PGIVHYKG--------SIGks--kQDSGi-------FFGVEL----CGS---AaGKGft 166 
XP_003198851  113 NGKQ--Lk--------------GIIRYIGsitdysinPLA--------Gt-------FFGVELqggdkG----K-GQN-- 154 
XP_022531577  102 KGSE--Vtve---qnGKWL--KGVIKYTG--------RLNepikdPIAGv-------FFGVELqg-dDKG---K-GQN-- 152 
2COZ_A         74 NGTYDGIAYFECKEKHGIFAPPQKI 98   human
XP_005802385  157 NGSFGSKTFFLCEKNCGIFAPFSRV 181 
EDO30311     1234 DGSFGGKRFFRCKPNRGIFVSYNKV 1258
XP_002604281 1028 DGVYNGQRFFVCKPNKGVFVSFNKV 1052
XP_002599874  106 DGTFRRKRFFNCPEDCGVFVALNKL 130 
XP_011417594  160 DGVFRKKRFFTCDQNCGIFAAIHKV 184  Pacific oyster
XP_009022371  159 SGIYREKKFFDCAKNCAQFTTLSNL 183 
XP_006007582  167 DGTFKGHRFFKCQENCGVFVPVSRI 191 
XP_003198851  155 DGSYYGKTYFKCSKNSGIFAPFTRI 179 
XP_022531577  153 NGTHHFKRLFTCGENCGIFAPFNRI 177 
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