2D8M


Conserved Protein Domain Family
BRCT_XRCC1_rpt1
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cd17725: BRCT_XRCC1_rpt1 
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins
XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one.
Links
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Statistics
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PSSM-Id: 349357
Aligned: 25 rows
Threshold Bit Score: 137.793
Created: 14-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [SC]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                       #   #            
2D8M_A        25 GVVVVLSGFQNPFRSELRDKALELGAKYRPDWTrdSTHLICAFaNTPKYSQVLglGGRIVRKEWVLDCHRMRRRLPSQRY 104 human
AAF27125      65 GVVFVLSGFVNPERSTLRSQALTMGATYQPDWNagSTLLICAFpNTPKFRQVEtnGGTIISKEWITECYAQKKLVDIEQY 144 thale cress
XP_001750282 321 GVRFTLSGYQNPRRGQLRDLALGMGAQYAAQWDsrCTHSISAFeQTPKNTQARrdGGIIVSKDWLESCDRAKRRVQEYRF 400 Monosiga brevic...
XP_001777620  81 GVVFTISGIQNPERGQLRTKGLEMGAQYRPDWTadCTLLVCAFlGTPKFKEIQakGGSIVSKDWILECYKQRKLVDFERF 160 Physcomitrella ...
XP_013394562 293 GVVFVMSGYQNPQRGELRDKAIEMGAQYRPDWGrgCTHLICAFsNTPKFQQVDg-KGCIVSHQWIKDSHRNKKLMNWKDY 371 Lingula anatina
XP_004334360 221 GVTFVISGIQNPQRADIRDKATKMGAKYQQNWDnrATHLICAFqDTPKYREVKgkGGIIVKPEWIVHSFAQKKRLPLTKY 300 Acanthamoeba ca...
CDW58301     221 GVTFVLSGFMHPMRGDLRDKATKMGATYRSNWDnqCTHLICAFpNTPKYKQVFg-KGLIVKKEWILDCFNEKRRMPLLRY 299 human whipworm
OON14280     309 GVVFCLSGYQNPLRSELREKALDLGASFRQDWGpsCTHLICAFaNTPKFKEVKg-KGIIVSDKWIQECYMKKSKVNWRPY 387 Opisthorchis vi...
XP_005840981 170 GVYISISGIENPSRAQLREQALSLGARYAPQWLsgCTHLICAFpNTPKYREAKkdGGVVVEASWLNDCAREQRKLPTSKY 249 Guillardia thet...
XP_002108457 288 KVIAVLSGYQNPLRGQLRTKLTNLGGQYRPDWGkdCTHLICAFkSTPKYRQVRktKGRIVSSDWLTDCYKHKKRLLTKNM 367 Trichoplax adha...

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