2FYS,2ERK,2GPH,2Z7L,2B9H,2B9F,2F9G,1GOL,2ZOQ


Conserved Protein Domain Family
STKc_ERK1_2_like

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cd07849: STKc_ERK1_2_like 
Click on image for an interactive view with Cn3D
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270839
Aligned: 28 rows
Threshold Bit Score: 579.645
Created: 18-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1GOL; Rattus norvegicus ERK2 binds MgATP; defined at 4A contacts.
  • Citation:PMID 8107865
  • Structure:2B9F; Saccharomyces cerevisiae Fus3 binds MgADP; defined at 4A contacts.
  • Structure:2ZOQ; Human ERK1 binds Na-inhibitor; defined at 4A contacts.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #### ## #            # #                              #             
2FYS_A     23 FDVGPRYTNLSYIGEGAYGMVCSAYDNLnkVRVAIKKISPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTieQ 101 Norway rat
P27638     33 FELPEEYEMINLIGQGAYGVVCAALHKPsgLKVAVKKIHPFNHPVFCLRTLREIKLLRHFR-HENIISILDILPPPSyqE 111 fission yeast
2B9H_A      7 YNISSDFQLKSLLGEGAYGVVCSATHKPtgEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIITIFNIQRPDSfeN 85  baker's yeast
2B9F_A      7 YNISSDFQLKSLLGEGAYGVVCSATHKPtgEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIITIFNIQRPDSfeN 85  baker's yeast
Q00859     17 FNVSEQYDIQDVVGEGAYGVVCSAIHKPsgQKVAIKKITPFDHSMFCLRTLREMKLLRYFN-HENIISILDIQKPRNyeS 95  Nectria haematococ...
P28869     62 FNVSDHYQILEIVGEGAYGIVCSAIHKPsqQKVAIKKIEPFERSMLCLRTLRELKLLKHFN-HENIISILAIQRPINyeS 140 Candida albicans
AAC98088   10 FNVSDDYEILDVIGEGAYGIVCSAIHKPsgQKVAIKKISPFDHSMFCLRTLREMKLLRYFN-HENIISILDIQQPQDfeS 88  Pneumocystis carinii
2F9G_A      7 YNISSDFQLKSLLGEGAYGVVCSATHKPtgEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIITIFNIQRPDSfeN 85  baker's yeast
CAY69271   26 YNISSDYRIQRVLGEGAYGIVCLAKHLPtgTDVAIKKIQPFERTLFCLRTLREIKILKHFK-HENIVALLDVQKPMSleT 104 Pichia pastoris GS115
CAG88452   11 FNISQNFQVIQVVGEGAYGVVCLAIHKPtgIKVAIKKLEPFEKPLFCLRALREIKLLTYFKkHENIISIFDVQKPLNfeN 90  Debaryomyces hansenii
Feature 1            ####  #  #                                      ## #         ##          
2FYS_A    102 MKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP- 180 Norway rat
P27638    112 LEDVYIVQELMETDLYRVIRSQPLSDDHCQYFTYQILRALKAMHSAGVVHRDLKPSNLLLNANCDLKVADFGLARSTTA- 190 fission yeast
2B9H_A     86 FNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDEs 165 baker's yeast
2B9F_A     86 FNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDEs 165 baker's yeast
Q00859     96 FNEVYLIQELMETDMHRAIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAAS- 174 Nectria haematococ...
P28869    141 FNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIAS- 219 Candida albicans
AAC98088   89 FSEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQILRALKAMHSADILHRDLKPSNLLLNANCDLKVCDFGLARSAVS- 167 Pneumocystis carinii
2F9G_A     86 FNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDEs 165 baker's yeast
CAY69271  105 FNEVYLIQEYMETDLHKVILSQNLTNDHYQYFIYQILRALKSLHGCNIVHRDLKPSNILLNSNCDLKVCDFGLSRVHLNd 184 Pichia pastoris GS115
CAG88452   91 FNEIYLIQEYMPSDLHKTIATQNLTDDHIQYFIYQILRGLKLIHSANVIHRDLKPSNILVNENCDLKICDFGLARLDILk 170 Debaryomyces hansenii
Feature 1                                                                                     
2FYS_A    181 ------DHDHTG---FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 251 Norway rat
P27638    191 ------QGGNPG---FMTEYVATRWYRAPEIMLSFREYSKAIDLWSTGCILAEMLSARPLFPGKDYHSQITLILNILGTP 261 fission yeast
2B9H_A    166 a---adNSEPTGqqsGMVEFVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 baker's yeast
2B9F_A    166 a---adNSEPTGqqsGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 baker's yeast
Q00859    175 ------QEDNSG---FMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTP 245 Nectria haematococ...
P28869    220 ------QEDNYG---FMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTP 290 Candida albicans
AAC98088  168 ------TEDSSS---FMTEYVATRWYRAPEIMLTFKEYTKAIDIWSVGCILAEMLSGRPLFPGKDYHHQLMLILDVLGTP 238 Pneumocystis carinii
2F9G_A    166 a---adNSEPTGqqsGMTEXVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTP 242 baker's yeast
CAY69271  185 dg--raSHVPKIs--MLTEYVATRWYRAPEIMLTSSQYSTAIDMWAVGCILAELYLRKPLFPGKDYRHQLLLIFEIIGTP 260 Pichia pastoris GS115
CAG88452  171 egydkrLAINSGi-sMLTEYVATRWYRAPEIMLTSSQYSTAIDMWSVGCILAELFTCTPLFPGNDYRHQLILIFQLLGTP 249 Debaryomyces hansenii
Feature 1                                                                                     
2FYS_A    252 SQ-EDLNCIINLKARNYLLSLPHKNKVPWNRLFPNa---------------DSKALDLLDKMLTFNPHKRIEvEQALAHP 315 Norway rat
P27638    262 TM-DDFSRIKSARARKYIKSLPFTPKVSFKALFPQa---------------SPDAIDLLEKLLTFNPDKRITaEEALKHP 325 fission yeast
2B9H_A    243 HSdNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRv---------------NPKGIDLLQRMLVFDPAKRITaKEALEHP 307 baker's yeast
2B9F_A    243 HSdNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRv---------------NPKGIDLLQRMLVFDPAKRITaKEALEHP 307 baker's yeast
Q00859    246 TM-EDYYGIKSRRAREYIRSLPFKKKVPFRTLFPKt---------------SDLALDLLEKLLAFNPVKRITvEEALKHP 309 Nectria haematococ...
P28869    291 NM-EDYYNIKSKRAREYIRSLPFCKKIPFSELFANtnnntstsntggrtniNPLALDLLEKLLIFNPAKRITvEDALKHP 369 Candida albicans
AAC98088  239 TM-EDYYGIKSRRAREYIRSLPFKKRVSFASIFPRa---------------NPLALDLLEKLLAFNPAKRVTaEEALQHN 302 Pneumocystis carinii
2F9G_A    243 HSdNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRv---------------NPKGIDLLQRMLVFDPAKRITaKEALEHP 307 baker's yeast
CAY69271  261 TG-IDYQSIKSVKAKEYIKSLPCYSKIPFGKIFRHn---------------DPQGLDLLGKLLTFNPQNRISvEEALSHP 324 Pichia pastoris GS115
CAG88452  250 TD-ADLTCIKSQRAKNYIKTLPYCSPLSLDQVFNRhpnrakr---fggqpiNPLGLDLLKKLLVFDPKERLTvEEALEHP 325 Debaryomyces hansenii
Feature 1                                                      
2FYS_A    316 YLeQYYDPSDEPIae--aPFKFDMel-----ddLPKEKLKELIFEETAR 357 Norway rat
P27638    326 YVaAYHDASDEPTa---sPMPPNLvdlycnkedLEIPVLKALIFREVNF 371 fission yeast
2B9H_A    308 YLqTYHDPNDEPEg---ePIPPSFfefdhykeaLTTKDLKKLIWNEIFS 353 baker's yeast
2B9F_A    308 YLqTYHDPNDEPEg---ePIPPSFfefdhykeaLTTKDLKKLIWNEIFS 353 baker's yeast
Q00859    310 YLePYHDPEDEPTa---pPIPEEFfdfdkhkdnLSKEQLKQLIYQEIMR 355 Nectria haematococca mpVI
P28869    370 YLqLYHDPNDEPIs---dKIPEDFfdfdkmkdqLTIEDLKKLLYEEIMK 415 Candida albicans
AAC98088  303 YLePYHDPDDEPTappisPSFFDFdri---kdsLTKNDLKILIYKEIMS 348 Pneumocystis carinii
2F9G_A    308 YLqTYHDPNDEPEg---ePIPPSFfefdhykeaLTTKDLKKLIWNEIFS 353 baker's yeast
CAY69271  325 YLsSYHDPLDEPFs---nPIPPDFfsfdtekaqMDGNELKKLLYQEIMT 370 Pichia pastoris GS115
CAG88452  326 YVsTYHDPEDEPTi---mPIPHEDfefdkskdkLSILELKRQLYNDIIK 371 Debaryomyces hansenii

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