3OTK


Conserved Protein Domain Family
Branch

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pfam02485: Branch 
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Core-2/I-Branching enzyme
This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans. This is a fmmily of glycosyl-transferases that are Type II membrane proteins that are found in the endoplasmic reticulum (ER) and Golgi apparatus.
Statistics
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PSSM-Id: 426795
Aligned: 41 rows
Threshold Bit Score: 205.594
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3OTK_D    86 IAYSIVVhH-KIEMLDRLLRAIYMPQNFYCIHVDRKaEESFLAAVQgi------aSCFDNVFVASqLESVVYASWTRVKA 158 house mouse
Q9LR71   103 LAYLISGtKgDSHRMMRTLQAVYHPRNQYVLHLDLEaPPRERMELAmsvktdptfREMENVRVMAqSNLVTYKGPTMIAC 182 thale cress
Q9SS69    54 FAYLISAsKgDAGKLKRLLRSLYHRRNHYLIHLDLEaPEEEHLEMIrfvageplfQPEGNVMIVGkPNLVTYRGPTMLAT 133 thale cress
Q9LFQ0    88 LAYLISGsSgDGQMLKRTLMALYHPNNQYVVHLDREsSPEERLDLSgfvanhtlfQRFQNVRMIVkANFVTYRGPTMVAN 167 thale cress
ANM67463  80 fGYLVSGsRgDLESLWRVLRTLYHPRNQYVVHLDLEsPAEERLELAkrvsqdpvfSDVGNVHMITkANLVTYRGPTMVAN 159
Q6DBE8    83 FAYLVSGsKgDLESLWRTLRALYHPRNQYIVHLDLEsPVDERSELAsrisndpmySKAGNVYMITkANLVTYTGPTMVAN 162 thale cress
Q9C9A1    49 FAYYITGgRgDNDRISRLLLAVYHPRNRYLIHLGAEaTDAERLALLsdlksvpavNAFGNVDVLGkVDRLSENGASKIAS 128 thale cress
Q9LIQ3    69 IAYLISGsSgDTRRILRLLYATYHPRNRYLLHLDSLaTQSERDRLAvdvqdvpifRAARNVDVIGkPDFAYQRGSSPMAS 148 thale cress
O02312   472 IAFARIVyK-DYEFIEKQVQVSFHPQNAFCFVIDINaSEEFKKRMRal------aACMPNVIVLAdEDPVYSSGHNVNLV 544 Caenorhabditis elegans
O16776   131 TAFARIVfA-DYEFIEKQVQASYHPQNVFCFAIDANsSAEFQRKMKkl------eQCLPNVVVLPvTESYDSKGHNINLA 203 Caenorhabditis elegans
3OTK_D   159 DLNCMKDLYRmNANWKYLINLSGMDFPIKTNLEIVRKLKCStgENN-LETEKMPPNKe--ERWKKryavvdgKLTNTGIV 235 house mouse
Q9LR71   183 TLQAVSILLReSLHWDWFLNLSASDYPLVTQDDLLYVFSNLsrNVNfIENMQLTGWKl-nQRAKSiiv--dpALYLSKKS 259 thale cress
Q9SS69   134 TLHAMALLLRcC-RWDWFINLSASDYPLVTQDDLIYAFSELprDLNfIQHTSRLGWKm-nKRGKPiii--dpGLYSLNKS 209 thale cress
Q9LFQ0   168 TLHAAAILLReGGDWDWFINLSASDYPLVTQDDLLHTFSYLprDLNfIDHTSNIGWKe-sHRAKPiii--dpGLYMSKKA 244 thale cress
ANM67463 160 TLHACAILLKqSKEWDWFINLSASDYPLVTQDDLIDTFSGLdrNLNfIDHSSKLGWKe-eKRAKPlii--dpGLYSTKKS 236
Q6DBE8   163 TLHACAILLKrTPDWDWFINLSASDYPLVTQDDLIHTFSTLdrNLNfIEHTSSLGWKy-kKRAMPlii--dpGLYMLNKS 239 thale cress
Q9C9A1   129 TLHAVSILLKlDPTWNWFIELSALDYPLITQDDLSHVFASVnrSLNfIDHTSDLAWKe-sQRIKPivv--dpALYLARRT 205 thale cress
Q9LIQ3   149 TLHGASILLRlSGTWDWFVSISVDDYPLVTQDELLHIMSHLpkDLNfVNHTSYIGWKe-sRKLKPviv--dpGLYLVEKT 225 thale cress
O02312   545 HNKCLKALLDiP-GWNYALLLQNHDLIMKSVYEMEQIFEWLggANDiFVTHEIGRVDvkkLKWDPmsl--klFINETEMD 621 Caenorhabditis elegans
O16776   204 HYNCMKKLESlR-GWGYLMLLQNHDVITKSVYELDRIFELLggVNDvFMSREIPERRkkhLKWDLksl--klFRNDSKNS 280 Caenorhabditis elegans
3OTK_D   236 kapp-------plktPLFSGSAYFVVTREYVGYVL--ENENIQKLMEWAQDTYSPDEFLWATIqripevpgsFPSSnKYD 306 house mouse
Q9LR71   260 diawttqrrslpnsfRLFTGSAWIMLTRSFLEYCIwgWDNFPRTILMYYTNFVSSPEGYFHTV---------ICNSkEFI 330 thale cress
Q9SS69   210 eiwwvsnqrslptsfKLFTGSAWTFLSRPFAEYCIigYDNLPRTLLLYYTNFVSSPEGYFQTL---------ICNSdEFK 280 thale cress
Q9LFQ0   245 dvfwvsqkrsmptafKLFTGSAWMMLSRPFVDYFIwgWDNLPRIVLMYYANFLSSPEGYFHTV---------ICNArEFT 315 thale cress
ANM67463 237 dvfwvtprrtmptafKLFTGSAWMVLSRSFVEYCIwgWDNLPRTLLMYYTNFLSTPEGYFHTV---------ICNApEYS 307
Q6DBE8   240 nvllvrpnrslpsafKLF--TAWMALSHAFVEYIIygWDNLPRTLLMYYTNFVSSPEGYFHTV---------ICNVpEFS 308 thale cress
Q9C9A1   206 qlftatekrptpdafKVFTGSPWIVLSRPFLEYCIfgWDNLPRILLMYFNNVILSEECYFHTV---------ICNApEFS 276 thale cress
Q9LIQ3   226 dmffasqkrelpkafKLFSGPSFSILSRNFMEHCVlgTDNFPRTLLMYLSNTPDSLSNYFPTI---------LCNTdTFK 296 thale cress
O02312   622 klll-------ttpmKIVKGWVHCSLSRASVEWMFqkLDPSIFMHQLNQ-GRYGVDEQYFPILqan----aeFGMPgHFT 689 Caenorhabditis elegans
O16776   281 dy-----------elEISSGSVHSSLSRAAVKWLVeeVDLSIFIDQWNQ-TDYGADEQFISTFqms----pdLKMPgHFT 344 Caenorhabditis elegans
3OTK_D   307 LSDMNAIA------RFVKWQyfegdvsnGAPYPPCSGVhvrsVCVFGAGDLSWML 355 house mouse
Q9LR71   331 NTAIGHDL------HYIAWD-----------SPPKQH-----PRSLSLKDFDNMV 363 thale cress
Q9SS69   281 NTTVNHDL------HYIAWD-----------NPPKQH-----PKILGTRDYRKMV 313 thale cress
Q9LFQ0   316 NTTVNSDL------HFISWD-----------NPPKQH-----PHHLTLDDFQRMV 348 thale cress
ANM67463 308 STVLNHDL------HFISWD-----------RPPKQH-----PRALTINDTERMi 340
Q6DBE8   309 KTAVNHDL------HYIAWD-----------KPPRQH-----PRMLSQRDMGKMi 341 thale cress
Q9C9A1   277 NTTVNGDL------RYMIWD-----------SPPKME-----PHFLTISDFDQMA 309 thale cress
Q9LIQ3   297 KTIMNNNL------LYLASN-----------DTSKER-----YHQLDHKEFTEMV 329 thale cress
O02312   690 DECLQQGKttefitRIALWVp-------ESKCDTNMTRh--aVCIIGLEHFQAVA 735 Caenorhabditis elegans
O16776   345 NECIHNDTaivtisRLARWVpiy--ldrAAHCATGTVRh--dICIFGIEDFRAIS 395 Caenorhabditis elegans
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