4ICZ,4GE5


Conserved Protein Domain Family
PTPc-N9
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cd14543: PTPc-N9 
catalytic domain of tyrosine-protein phosphatase non-receptor type 9
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9), also called protein-tyrosine phosphatase MEG2, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN9 plays an important role in promoting intracellular secretary vesicle fusion in hematopoietic cells and promotes the dephosphorylation of ErbB2 and EGFR in breast cancer cells, leading to impaired activation of STAT5 and STAT3. It also directly dephosphorylates STAT3 at the Tyr705 residue, resulting in its inactivation. PTPN9 has been found to be dysregulated in various human cancers, including breast, colorectal, and gastric cancer.
Links
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Statistics
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PSSM-Id: 350391
Aligned: 14 rows
Threshold Bit Score: 467.612
Created: 28-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 16 residue positions
Conserved feature residue pattern:x x x x x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Structure:4ICZ: Human PTPN9 binds Her2 phosphopeptide; contacts at 4A
  • Structure:4GE5: Human PTPN9 binds inhibitor compound 5; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         #####                                          
4ICZ_A        24 QKQGIYEEYEDIRRenpvGTFHCSMSPGNLekNRYGDVPCLDQTRVKLtkrsg-htqtDYINASFMDGYkqkNAYIGTQG 102 human
NP_001081203 397 KKRGIFQEYEEIRKdppvGSFDISKKSHNQvkNRYSDVLCLDQSRVKLglvgt-dettDYINASFMDGYkrkNAYIATQG 475 African clawed ...
XP_001637755 323 GRRGIRRQYLELRNmpveGTFLRTKLRANLrkNRYTDVLCVEETRVPLspvde-ddcsDYIHANFTDGYrqhKAFIATQG 401 starlet sea ane...
NP_572576    529 GRHGLIKEYADIRNrapeGTFLHARMRANLtkNRYTDVLCYDHSRVVLahedg-depsDYINANFVDGYkqkNAYISTQG 607 fruit fly
XP_005163030 286 QRSGIYLEYEELRReqppGTFTCALAAHNQerNRYGDVLCLDQTRVRLkarr--nersDYINASFMDGYkqkNAYIGTQG 363 zebrafish
P43378       299 QKQGIYEEYEDIRRenpvGTFHCSMSPGNLekNRYGDVPCLDQTRVKLtkrsg-htqtDYINASFMDGYkqkNAYIGTQG 377 human
XP_413696    289 QKRGIYEEYEDIRRrspaGTFVCSLAPYNQekNRYGDVPCLDQTRVKLakpysrpeltDYINASFMDGYkqrNAYIGTQG 368 chicken
XP_014343266 283 QKRGIYEEYEDIRReipaGTFTCSLAPFNQekNRYGDVLCLDQSRVKLkhpnk-nertDYINASFMDGYkqkHAYIGTQG 361 coelacanth
XP_019638646 350 GKRGIYKEYAMIRAeapaGTFNCSKAPYNQckNRYTDVLSLDHSRVKLnilde-ddttDYINANFMDAYkhkNAFIATQG 428 Belcher's lancelet
XP_002740569 287 KKSGIYKEYAKIRLepptGTFQASRLKVNAvkNRYTDVPSYDHTRVPLnfing-dpnsDYINANYMDGYkqkNAFIAAQG 365 Saccoglossus ko...

Feature 1                                        ##                                              
4ICZ_A       103 PLentyrDFWLMVWEQkvLVIVMTTRFeegGRRKCGQYWPlekdsrirfGFLTVTNLGVENMnhYKKTTLEIHnteerqk 182 human
NP_001081203 476 PLpktfdDFWRMVWEQkvLIIVMTTRVierGRIKCGQYWPleagrsedtGHFIIRNIHIDLFqdFKLTHFEVYnkqtdes 555 African clawed ...
XP_001637755 402 PLpnttsDFWRMVWEQgaMVIVMITRCmerGRVKCRRYWPedgd-cddhVDLRVQHVETQEYedHVERIFTIDhvqtgqs 480 starlet sea ane...
NP_572576    608 PLpktsqDFWRMIWEQhcLVIVMTTRVmerGRVKCGQYWEpteesslefGDYHVRTISVECNedYMVASLELRniktdei 687 fruit fly
XP_005163030 364 PLektygDFWRMVWEQnvLVIVMTTRTdegGRRKCGQYWPqeeggqevyGYIAVVNHRVDNHahYNQTTLELHntetfeq 443 zebrafish
P43378       378 PLentyrDFWLMVWEQkvLVIVMTTRFeegGRRKCGQYWPlekdsrirfGFLTVTNLGVENMnhYKKTTLEIHnteerqk 457 human
XP_413696    369 PLentygDFWRMVWEQnvLVIVMTTRLeegGRRKCGQYWPlekdfqmrfGALTITNLGVENLshYKKTILEIHsaegrer 448 chicken
XP_014343266 362 PLentynDFWKMVWEQnvLVVVMTTRTdegGRRKCGQYWPlqkg-cqnyGSLTVTNLGVDSFkhYNKTTLEMYntetrek 440 coelacanth
XP_019638646 429 PLprtfpDFWRMVWEQqvLIIVMTTRVverGRLKCGQYWPneegmldhyANFRVTNLEIQAGddYTISRLKLDnletdes 508 Belcher's lancelet
XP_002740569 366 PLpktfaDYWRMIWEQtvLVIVMTTRTverGRLKCGQYWPneenstevyGDVSVINKMIEKKndYTISTLQMRnsktdev 445 Saccoglossus ko...

Feature 1                     #                                           #######                
4ICZ_A       183 RQVTHFQFLSWPDYGVPssAASLIDFLRVVRNQqslavsnmgarskgqcpePPIVVHCSAGIGRTGTFCSLDICLAQLee 262 human
NP_001081203 556 RSVAHYQYMSWPDFGVPksASAMLDFRSQVKQHqavavqnlgmewtghpagPPIVVHCSAGIGRTGTFCTLDICLSRLed 635 African clawed ...
XP_001637755 481 RTIIHFQMTSWPDFGVPssAESCLHILGLVRQAqasavlamgpswkghpsgPPIVVHCSAGIGRTGTFCTLDINVSRLqh 560 starlet sea ane...
NP_572576    688 RNVSHWQFTSWPDYGVPssAMAMLNFLQKVREKqaqlvqglgdtwaghprgPPIVVHCSAGIGRTGTFITLDICISRLed 767 fruit fly
XP_005163030 444 RQVTHFQFLSWPDYGVPssAVSLIDFLGAVKHQqqwavqafgtqwrghplgPPMVVHCSAGIGRTGTFCALDICLSQLqd 523 zebrafish
P43378       458 RQVTHFQFLSWPDYGVPssAASLIDFLRVVRNQqslavsnmgarskgqcpePPIVVHCSAGIGRTGTFCSLDICLAQLee 537 human
XP_413696    449 RLLSHFQYLSWPDYGVPssAATLIDFLGAVKQQqrvavsalgprfkghpggPPLVVHCSAGIGRTGTLCALDICLSQLqd 528 chicken
XP_014343266 441 RPVIHFQYLSWPDYGVPssAAALIDFLGAVKQQqrlsvrtmgqrwkghpggPPMVVHCSAGIGRTGTLCALDICLSQLqd 520 coelacanth
XP_019638646 509 REVAHFQFTSWPDFGVPrsAAAMLDFLAEVRQYqadgckamgpawaghhrgPPIVVHCSAGIGRTGTFCTLDICLDRLad 588 Belcher's lancelet
XP_002740569 446 RDVTHFQFTSWPDFGVPssAAAMLDFLSEVRSYqarnlkslgdqwqghtlgPPILVHCSAGIGRTGTFCTLDISLARLnd 525 Saccoglossus ko...

Feature 1                             #          
4ICZ_A       263 LGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYK 294 human
NP_001081203 636 IGTVDVLQTVKRMRTQRAFSIQTWDQYYFCYM 667 African clawed frog
XP_001637755 561 EGVCEIVNTVKYLRTQRAHMIQTPEQYEFCHL 592 starlet sea anemone
NP_572576    768 VGTADIRGTVEKIRSQRAYSIQMPDQYVFCHL 799 fruit fly
XP_005163030 524 VGTLNICQTVRRMRSQRAFSIQTPEQYYFCHA 555 zebrafish
P43378       538 LGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYK 569 human
XP_413696    529 VGTLDIQQTVQRMRTQRAFSIQTPEQYYFCYS 560 chicken
XP_014343266 521 VGTLNVYQTVRRMRTQRAFSIQTPEQYYFCYT 552 coelacanth
XP_019638646 589 IGTVNVKETVQRMRTQRAFSIQTPDQYHFCHT 620 Belcher's lancelet
XP_002740569 526 IGTIDVKTTVQRMRTQRAFTIQTPDQYEFCHF 557 Saccoglossus kowalevskii

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