3KYJ,6S1K,7C1I,1WN0,4EUK,2R25


Conserved Protein Domain Family
Hpt
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pfam01627: Hpt 
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Hpt domain
The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein pfam00072).
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Statistics
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PSSM-Id: 426352
Aligned: 229 rows
Threshold Bit Score: 32.7079
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KYJ_A                    11 EIWALYADDGAQALDAMEASLlalqagedAAAHVGPLFRAVHTFKGNSRVLGLSVVESRAHLCEDliglvrdAGVPMDGE 90   Ce...
Q9KPJ8                   689 DSVHLFEQSMPAYLAVLDSNM--------VAKDQEGIVSEAHKIKGAAGSVGLKRIQKIAQKAQS-------PEAPAWWE 753  Vi...
PRJNA291949:FORC17_2506  689 DSIRMFEEMMPEYLEILDSNM--------IAKDQPGIVSEAHKIKGAAGSIGLKRIQSVAQKAQS-------PDMPAWWE 753 
Q9CNW0                   521 KNLALFKETMPEYMQALMTAYsvy---qqDESQKADVLSCAHKIKGAAASVGLKRIQQIAAQAQD-------PEQGEWTE 590  Pa...
Q8EHA2                    29 KSVVLFEQLMPEYVGNLVKAN--------EAADKDTLCSEAHKFKGAAGSVGLKRIQQIAQLLQH-------GEEADWES 93   Sh...
CDW59047                 684 DGLAVFEKMMPGYVSVLESNL--------TAQDKKGIVEEGHKIKGAAGSVGLRHLQQLGQQIQS-------PDLPAWED 748 
Q7N085                   687 NSLSVFEKMMPGYLSVLDSNM--------TAKDQKGITEEAHKIKGAAGSVGLRHLQQLAQQIQS-------PDLPAWWD 751  Ph...
Q847W1                  1133 EIARVFSQSMAMDIENLQAAP-----------TERDKKRVIHGIKGAVGAIGISMLTELCIEAER-------VTAAEFDR 1194 Vi...
Q7UZ66                   903 AIVSDFIVRLDQRLVDMRNEL--------RDQRFDALELSAHWLKGAGGTVGYGDLTQPSRDLID-------AALAANPA 967  Pi...
Q7UZ66                   777 AIAGDFVSRLHTRLDGIEQAI--------QESKFDFVHGEAHWLKGAGGTVGLDVFTEPARTLEQ-------AAKDGSPD 841  Pi...

3KYJ_A                    91 IVEillf-asdTLRAMLEETAAS 112  Cereibacter sphaeroides
Q9KPJ8                   754 NISdwveeiknEYQSDIALLKRW 776  Vibrio cholerae
PRJNA291949:FORC17_2506  754 NIAdwveeiknEYQNDIQILKSW 776 
Q9CNW0                   591 NIHdwvqqlaqYWLLDVEALERY 613  Pasteurella multocida
Q8EHA2                    94 KHAtwvaqiveFASADLQQLKQF 116  Shewanella oneidensis
CDW59047                 749 NVGewieemkeEWRHDVEVLKAW 771 
Q7N085                   752 NVQewvdelkqEWRKDTEILGEW 774  Photorhabdus laumondii subsp. laumondii
Q847W1                  1195 RAAel----ilRIEQEIDNIDYW 1213 Vibrio parahaemolyticus
Q7UZ66                   968 DCE--------TYLSQIESVRAR 982  Pirellula sp.
Q7UZ66                   842 IAQ--------SILNDIRELHGR 856  Pirellula sp.
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