7OKX


Conserved Protein Domain Family
ELL

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pfam10390: ELL 
RNA polymerase II elongation factor ELL
ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.
Statistics
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PSSM-Id: 463068
Aligned: 31 rows
Threshold Bit Score: 283.788
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7OKX_M                11 EEQRYGLSCGRLGQD--NITVLHVKLTETAIRALETYQS----HKNLIPFRPSIQFQGLHGLVKIPKNDPLne------- 77  
EDV21077               5 QSGNYTLSRNRSTDD--SIVAVQVKLTDSCLNALDSYIKf---ALKLNEDHPTLSCDGKTGRIFIPDKNGG--------- 70  
XP_008187674          14 SNQNNGLMPKQRTGK--NKTLFFVKLTDSCLKAVEDYLRccqqGNSENLPKPRIQFKGNEGQLCVPSISKN--------- 82  
WGS:AAPU:GI13662-PB   17 SSGNYGMSQSHRYTDd-TKEYIFLKLTDSAYRAIEEYQRnenaKRLAPGQCAKIQCNGNTGFIHFPLPSSDssnsvnng- 94  
KPU78916              16 STGNYGMSQRHRYTDd-SKEYIIVKLTDSAFRAIEEYQRddhaKRLPPGQRAKIQFTGNEGVIQFPRSSSDanghhnnps 94  
XP_694180              6 QEHRYGLSCGKINKSipNKTIFHVKLTDTAIRTLEAYQN----LKGSLPNQPAICFKGNQGYIKIPASSDSpd------- 74  
XP_005470820           6 QEHRYGLSCAKINKNtpNQTLYHVKLTDTAIRTLEAYQN----LKTSLSNQPAICFKGSQGYIKIPAPTPEspd------ 75  
XP_006629044           6 QEERYGLSCGKINKNipNKTLYHVKLTDTAIRALEAYQN----FKASIPHQPVICFKGSQGYIKIPVPSADssg------ 75  
CAG00837                 --------------------------------------------------------------------------------      spotte...
XP_005989805           6 EAGHFSLSYSKVSQVs-RKTFYHVKLTDSALRTLQAFRN----LKISLPKQSLISFRGNRGYIKIPDDNYPng------- 73   coelac...
7OKX_M                78 -----------------vHNFNFYLSNVGkdn-pqGSFDC--IQQtfsssGASQLNCLGFIQDKITVCATNDSYQMTRER 137 
EDV21077              71 ------------------RDFQFSCTTLPed---rGPFECysMHQs----HSDKMIYEGSITTRMSIQATDEIYAKTKIK 125 
XP_008187674          83 ------------------YTFDFSLSNTTdaaaprSSFEC--IRQn----TSRSLEYVGTLNRHIRVLANDDVYEATRHR 138 
WGS:AAPU:GI13662-PB   95 ----------sgsgmeagRKFGFTIDDLE------GTLEC--IQQ-----QQQELDVLGALARRMRIHANDDVYDTTRSK 151 
KPU78916              95 tngngngngngnsgndpgRKFLFTINNME------GTLEC--VQQ-----QQQNLGVLGAVTFRMRIHANDDVYDTTRTK 161 
XP_694180             75 ----------------afRVFSFYLSSDSkdk-pqASFDC--VHQfvsgdGRDRLEGQGSIQDKITVCATDDSYQMTRER 135 
XP_005470820          76 ----------------gfRVFSFYLSSDSkdk-pqSSFDC--IHQyvsgeGRDHLEGQGSIQDKITVCATDDSYQTTRER 136 
XP_006629044          76 ----------------alRVFSFYLSSDSkdk-pqASFDC--IHQyvssdGREQLECQGSIQDKITVCATDDSYQMTRER 136 
CAG00837               1 ------------------------------------------------sdGREQLEGQGVIQDKITVCATDDSYKMTRER 32   spotte...
XP_005989805          74 -----------------lRVFSFDVSNDSkdk-phSGFDC--IRQns-cgGQCQLGFLGSIQDKITICATDDSYQATRDR 132  coelac...
7OKX_M               138 MTQAEEESRNRSTKVIKPG--GPYVGKRVq-iRKAP-------------------------------------------- 170 
EDV21077             126 MEKAEEERKESRAKLVNPVskATKGGRn---kSKPVl------------------------------------------- 159 
XP_008187674         139 MVAVEELHKKSCTREIELDs-KSALSRKIr--KNPAqiranrhn------------------------------------ 179 
WGS:AAPU:GI13662-PB  152 MARVEETEKSKCIREIKPN--QSDIGRKV---KKPAsasshhsgnnnsnnnssnsnsfns-------------------- 206 
KPU78916             162 MAIAEETEKSKCIREIKPN--QSDIGRKV---KKPPsmmsssnnnnnnnnassfssfnsssansgsmttttafhhhnnnn 236 
XP_694180            136 MSQVEKDIWSRSAIEIKPG--STRPSKCVk-iKKKQ-------------------------------------------- 168 
XP_005470820         137 MSQVEKDIWSRSAIEIKPG-----PSKCVkvqRKQG-------------------------------------------- 167 
XP_006629044         137 VSQVEKETWSRAAIEIKPG--TTHPSKCVkiqKKHG-------------------------------------------- 170 
CAG00837              33 MSRVKKDNWSRSVIEIKPG--ATHQIKGVkfhKRLA-------------------------------------------- 66   spotte...
XP_005989805         133 VTQVEKESWSRTAIEIKPG--ATYRSKGVnvaKKPG-------------------------------------------- 166  coelac...
7OKX_M                   --------------------------------------------------------------------------------     
EDV21077                 --------------------------------------------------------------------------------     
XP_008187674             --------------------------------------------------------------------------------     
WGS:AAPU:GI13662-PB      --------------------------------------------------------------------------------     
KPU78916             237 nnsginnnnnsssnsfnnnnnnnnhsrklasspfnglgvgmgggsnsatnsasssinsssaaaaayssrspnpsmlgasg 316 
XP_694180                --------------------------------------------------------------------------------     
XP_005470820             --------------------------------------------------------------------------------     
XP_006629044             --------------------------------------------------------------------------------     
CAG00837                 --------------------------------------------------------------------------------      spotte...
XP_005989805             --------------------------------------------------------------------------------      coelac...
7OKX_M               171 -----------------------QAVSDTVP----------ERKRSTPMNP----------------------------- 188 
EDV21077             160 -----------------------LRPTRTIP----------ASKPLLPSRS----------------------------- 177 
XP_008187674         180 ----------------------------------nnsynnvNITNNVPKPIiskpip----------------------- 202 
WGS:AAPU:GI13662-PB  207 nnsrklvsspfngltsssvataaTAVAAAAT----------SIASRSPNPNilgasgtvngsrstalantfangisqgya 276 
KPU78916             317 tvngttgggggryhhqyhggagaGAASSLAStfasgisqgyNMSGSSPRDSaqgqmsggangr----------------- 379 
XP_694180            169 ------------------------SLSASFD----------STNKHSPSN------------------------------ 184 
XP_005470820         168 -----------------------LVSSSD------------SNNKHSPNN------------------------------ 182 
XP_006629044         171 -----------------------APMPGDSF----------PSHKHSPTG------------------------------ 187 
CAG00837              67 -----------------------PLCASEN-----------SFQRQSASN------------------------------ 82   spotte...
XP_005989805         167 -----------------------LCSISKGL----------NFRKSSPASP----------------------------- 184  coelac...
7OKX_M               189 --------------------------------------ANTIRK---------------THSSSTISQRPYRDRVIHLLA 215 
EDV21077             178 -----------------------------------------------------------TNYVTTSSNKPYKDRVIHYLA 198 
XP_008187674         203 -----------------------------------------------------phiplpTNHASDISKKPLRDRIIHLLA 229 
WGS:AAPU:GI13662-PB  277 lsgssprdsnsttagtvagtalggsfnsngrnkmlngsGSNSRSgntksggangngggnGNKMSDVSRRSIRERLIHLLA 356 
KPU78916             380 ---------------------------srmasgggnatGASSRSannk--------ssgGNKMSEVSRRNIRERLVHLLA 424 
XP_694180            185 ------------------------------------------KR---------------NGGPSLVTHRPLRERVIHILA 207 
XP_005470820         183 ------------------------------------------KR---------------SLVPSPVAHRPLRDRIIHLLA 205 
XP_006629044         188 ---------------------------------------AGPKR---------------SSAPSPVAHRPLRDRIIHLLA 213 
CAG00837              83 ------------------------------------------RR---------------NSCIATATHKPFRERIIHLLA 105  spotte...
XP_005989805         185 --------------------------------------TQMPKK---------------AAATSTLTHRALRERLIHLLA 211  coelac...
7OKX_M               216 LKAYKKPELLARLQKDG-VNQKDKNSLGAILQQVANLnsKDLSYTLKDYVFKELQRD-WPGYSEIDRRSLESVLSRKL 291 
EDV21077             199 IQPLNKLELLTRLHKDGrANKKDTNRLGSILKEVAVM--KNNKFYLHKHLYSEVQVDkFSSYTENDKRLVALNISKYC 274 
XP_008187674         230 LRPYKKPELISILNRDG-LKDKDRTQIMSVLSHVAQA--KDNAYYLLRHIWNEVQED-WPFYSSQDHIVLKRRKPQNL 303 
WGS:AAPU:GI13662-PB  357 LKPFKKPELYARLKNEG-IKDRERNLIGNILTDISTM--SHNTFNLRRQMWNDVDEN-WPFFSEQELQQLKRRKPQNL 430 
KPU78916             425 LKAFKKPELFARLKNEG-IRDRERNQITNILMDISTM--SHNTYNLRRQMWNDVDEN-WPFFSEQELQQLKRRKPQNL 498 
XP_694180            208 LKPYSKPELLLWLEREK-ASPKDKADLSPVLDEVAKLnpKEHSFTLKDDFYRHVRKD-WPGYVEEERQLIQRVLARKL 283 
XP_005470820         206 LKPYRKPELLLWLDRER-ATPKDKADLTSVLEEVAKLspKDHSYSLKDELYRHVQRD-WPGYLEEEKQLIHRLLIRKL 281 
XP_006629044         214 LKPYRKPELILWLERDR-ASPKDKADLGSVLDEVAKLnpKNHSFTLKDEFYRHVHRD-WPGYTEDERQHIHRLLARKL 289 
CAG00837             106 LKAYRKPELLLWMEQEK-ASPRDKAELGGILEEVAKVnpKDGSYVLQDHFYRLVQKD-WPNYSEEERRLIGRLLA--- 178  spotted ...
XP_005989805         212 LKPFRKPELILWLEREG-AHPRDKTELPSLLDEVAKLnpKENSYSLKEELYRLVQTD-WPGYSKEDRQLLHRLLLRkq 287  coelacanth
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