1TYT,2WBA


Conserved Protein Domain Family
trypano_reduc
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TIGR01423: trypano_reduc 
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trypanothione-disulfide reductase
Trypanothione, a glutathione-modified derivative of spermidine, is (in its reduced form) an important antioxidant found in trypanosomatids (Crithidia, Leishmania, Trypanosoma). This model describes trypanothione reductase, a possible antitrypanosomal drug target closely related to some forms of glutathione reductase.
Links
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Statistics
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PSSM-Id: 200098
Aligned: 4 rows
Threshold Bit Score: 1029.92
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1TYT_A   2 SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGW 81  Crithidia fasciculata
P13110   2 SKAFDLVIIGAGSGGLEAGWNAATLYKKRVAVVDVQTVHGPPFFAALGGTCVNVGCVPKKLMVTGAQYMDQLRESAGFGW 81  Trypanosoma congolense
P39040   2 SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGW 81  Crithidia fasciculata
2WBA_A   2 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVTGAQYMDHLRESAGFGW 81  Trypanosoma brucei TR...

1TYT_A  82 ELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFHQGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATG 161 Crithidia fasciculata
P13110  82 EFDASTIKANWKTLIAAKNAAVLDINKSYEDMFKDTEGLEFFLGWGALEQKNVVTVREGADPKSKVKERLQAEHIIIATG 161 Trypanosoma congolense
P39040  82 ELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFHQGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATG 161 Crithidia fasciculata
2WBA_A  82 EFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATG 161 Trypanosoma brucei TR...

1TYT_A 162 SWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQ 241 Crithidia fasciculata
P13110 162 SWPQMLKIPGIEHCISSNEAFYLEEPPRRVLTVGGGFISVEFAGIFNAYKPVGGKVTLCYRNNPILRGFDYTLRQELTKQ 241 Trypanosoma congolense
P39040 162 SWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQ 241 Crithidia fasciculata
2WBA_A 162 SWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQ 241 Trypanosoma brucei TR...

1TYT_A 242 LRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLDKAGVEVAKNGAIKVDAYSKTNVDN 321 Crithidia fasciculata
P13110 242 LVANGIDIMTNENPSKIELNPDGSKHVTFESGKTLDVDVVMMAIGRLPRTGYLQLQTVGVNLTDKGAIQVDEFSRTNVPN 321 Trypanosoma congolense
P39040 242 LRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLDKAGVEVAKNGAIKVDAYSKTNVDN 321 Crithidia fasciculata
2WBA_A 242 LTANGIEIMTNENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPN 321 Trypanosoma brucei TR...

1TYT_A 322 IYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMH 401 Crithidia fasciculata
P13110 322 IYAIGDVTGRIMLTPVAINEGASVVDTIFGSKPRKTDHTRVASAVFSIPPIGTCGLTEEEAAKSFEKVAVYLSCFTPLMH 401 Trypanosoma congolense
P39040 322 IYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMH 401 Crithidia fasciculata
2WBA_A 322 IYAIGDITDRLMLTPVAINEGAALVDTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMH 401 Trypanosoma brucei TR...

1TYT_A 402 NISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAYFYQKG 481 Crithidia fasciculata
P13110 402 NISGSKYKKFVAKIITDHGDGTVVGVHLLGDSSPEIIQAVGICMKLNAKISDFYNTIGVHPTSAEELCSMRTPSHYYIKG 481 Trypanosoma congolense
P39040 402 NISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAYFYQKG 481 Crithidia fasciculata
2WBA_A 402 NISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVKG 481 Trypanosoma brucei TR...

1TYT_A 482 KRVEKI 487 Crithidia fasciculata
P13110 482 EKMETL 487 Trypanosoma congolense
P39040 482 KRVEKI 487 Crithidia fasciculata
2WBA_A 482 EKMEKL 487 Trypanosoma brucei TREU927
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