1DZI,1AOX,1MJN,1CQP,1CK4,1N3Y,1BHQ,1JLM,1IDN


Conserved Protein Domain Family
vWA_integrins_alpha_subunit

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cd01469: vWA_integrins_alpha_subunit 
Click on image for an interactive view with Cn3D
Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta sub-unit. Each sub-unit has a large extracellular portion, a single transmembrane segment and a short cytoplasmic domain. The N-terminal domains of the alpha and beta subunits associate to form the integrin headpiece, which contains the ligand binding site, whereas the C-terminal segments traverse the plasma membrane and mediate interaction with the cytoskeleton and with signalling proteins.The VWA domains present in the alpha subunits of integrins seem to be a chordate specific radiation of the gene family being found only in vertebrates. They mediate protein-protein interactions.
Statistics
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PSSM-Id: 238746
Aligned: 13 rows
Threshold Bit Score: 239.18
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
integrin-coll..integrinmetal
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:integrin-collagen binding site
Evidence:
  • Comment:three loops on the upper surface of integrin that coordinate the metal through MIDAS residues also engage collagen
  • Structure:1DZI; integrin alpha2beta1 binds collagen

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               ### #                                                                 #
1DZI_A       3 IDVVVVCDESNSIYP--WDAVKNFLEKFVQGLdigptkTQVGLIQYANNPRVVFNLNTYKtkeeMIVATSQTSQYGGdlT 80   human
1AOX_A       8 IDVVVVCDESNSIYP--WDAVKNFLEKFVQGLdigptkTQVGLIQYANNPRVVFNLNTYKtkeeMIVATSQTSQYGGdlT 85   human
1MJN_A       3 VDLVFLFDGSMSLQPdeFQKILDFMKDVMKKCsn--tsYQFAAVQFSTSYKTEFDFSDYVkrkdPDALLKHVKHMLLl-T 79   Escherichia coli
1CQP_A       3 VDLVFLFDGSMSLQPdeFQKILDFMKDVMKKLsn--tsYQFAAVQFSTSYKTEFDFSDYVkwkdPDALLKHVKHMLLl-T 79   human
1CK4_B       5 LDIVIVLDGSNSIYP--WESVIAFLNDLLKRMdigpkqTQVGIVQYGENVTHEFNLNKYSsteeVLVAANKIGRQGGlqT 82   Norway rat
1N3Y_A      10 QDIVFLIDGSGSISSrnFATMMNFVRAVISQFqr--psTQFSLMQFSNKFQTHFTFEEFRrssnPLSLLASVHQLQGf-T 86   human
1BHQ_1       2 SDIAFLIDGSGSIIPhdFRRMKEFVSTVMEQLkk--skTLFSLMQYSEEFRIHFTFKEFQnnpnPRSLVKPITQLLGr-T 78   human
1JLM         7 SDIAFLIDGSGSIIPhdFRRMKEFVSTVMEQLkk--skTLFSLMQYSEEFRIHFTFKEFQnnpnPRSLVKPITQLLGr-T 83   human
1IDN_1       2 SDIAFLIDGSGSIIPhdFRRMKEFVSTVMEQLkk--skTLFSLMQYSEEFRIHFTFKEFQnnpnPRSLVKPITQLLGr-T 78   human
O75578     166 MDVVIVLDGSNSIYP--WSEVQTFLRRLVGKLfidpeqIQVGLVQYGESPVHEWSLGDFRtkeeVVRAAKNLSRREGreT 243  human
Q9UKX5     163 MDIVIVLDGSNSIYP--WVEVQHFLINILKKFyigpgqIQVGVVQYGEDVVHEFHLNDYRsvkdVVEAASHIEQRGGteT 240  human
Q13349     149 MDIVFLIDGSGSIDQndFNQMKGFVQAVMGQFeg--tdTLFALMQYSNLLKIHFTFTQFRtspsQQSLVDPIVQLKGl-T 225  human
Q60677     194 TEIAIVLDGSGSIGPsdFQKAKNFISTMMRNFyekcfeCNFALVQYGAVIQTEFDLQESRdinaSLAKVQSIVQVKEv-T 272  house mouse
Feature 1                                                                                      
1DZI_A      81 NTFGAIQYARKYaysaASGGRRSATKVMVVVTDGESHDgsml-kavIDQCNhdNILRFGIAVLGylnrnaldtknlIKEI 159  human
1AOX_A      86 NTFGAIQYARKYaysaASGGRRSATKVMVVVTDGESHDgsml-kavIDQCNhdNILRFGIAVLGylnrnaldtknlIKEI 164  human
1MJN_A      80 NTFGAINYVATEvfreELGARPDATKVLIIITDGEATDsg-----nIDAAK--DIIRYIIGIGKhfqt-----kesQETL 147  Escherichia coli
1CQP_A      80 NTFGAINYVATEvfreELGARPDATKVLIIITDGEATDsg-----nIDAAK--DIIRYIIGIGKhfqt-----kesQETL 147  human
1CK4_B      83 MTALGIDTARKEafteARGARRGVKKVMVIVTDGESHDnyrl-kqvIQDCEdeNIQRFSIAILGhynrgnlstekfVEEI 161  Norway rat
1N3Y_A      87 YTATAIQNVVHRlfhaSYGARRDAAKILIVITDGKKEGdsldykdvIPMADaaGIIRYAIGVGLafqn-----rnsWKEL 161  human
1BHQ_1      79 HTATGIRKVVRElfniTNGARKNAFKILVVITDGEKFGdplgyedvIPEADreGVIRYVIGVGDafrs-----eksRQEL 153  human
1JLM        84 HTATGIRKVVRElfniTNGARKNAFKILVVITDGEKFGdplgyedvIPEADreGVIRYVIGVGDafrs-----eksRQEL 158  human
1IDN_1      79 HTATGIRKVVRElfniTNGARKNAFKILVVITDGEKFGdplgyedvIPEADreGVIRYVIGVGDafrs-----eksRQEL 153  human
O75578     244 KTAQAIMVACTEgfsqSHGGRPEAARLLVVVTDGESHDgeel-paaLKACEagRVTRYGIAVLGhylrrqrdpssfLREI 322  human
Q9UKX5     241 RTAFGIEFARSEa--fQKGGRKGAKKVMIVITDGESHDspdl-ekvIQQSErdNVTRYAVAVLGyynrrginpetfLNEI 317  human
Q13349     226 FTATGILTVVTQlfhhKNGARKSAKKILIVITDGQKYKdpleysdvIPQAEkaGIIRYAIGVGHafqg-----ptaRQEL 300  human
Q60677     273 KTASAMQHVLDNifipSRGSRKKALKVMVVLTDGDIFGdplnlttvINSPKmqGVVRFAIGVGDrfkn-----nntYREL 347  house mouse
Feature 1                              
1DZI_A     160 KAIASIPTERYFFNVSDEAALLEK 183  human
1AOX_A     165 KAIASIPTERYFFNVSDEAALLEK 188  human
1MJN_A     148 HKFASKPASEFVKILDTFEKLKDL 171  Escherichia coli
1CQP_A     148 HKFASKPASEFVKILDTFEKLKDL 171  human
1CK4_B     162 KSIASEPTEKHFFNVSDELALVTI 185  Norway rat
1N3Y_A     162 NDIASKPSQEHIFKVEDFDALKDI 185  human
1BHQ_1     154 NTIASKPPRDHVFQVNNFEALKTI 177  human
1JLM       159 NTIASKPPRDHVFQVNNFEALKTI 182  human
1IDN_1     154 NTIASKPPRDHVFQVNNFEALKTI 177  human
O75578     323 RTIASDPDERFFFNVTDEAALTDI 346  human
Q9UKX5     318 KYIASDPDDKHFFNVTDEAALKDI 341  human
Q13349     301 NTISSAPPQDHVFKVDNFAALGSI 324  human
Q60677     348 KLIASDPKEAHTFKVTNYSALDGL 371  house mouse

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