1LMQ,1LZS,1EL1,1AT5,4YF2,1JUG


Conserved Protein Domain Family
LYZ_C
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cd16897: LYZ_C 
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C-type lysozyme
C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.
Links
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Statistics
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PSSM-Id: 340383
Aligned: 40 rows
Threshold Bit Score: 151.264
Created: 6-Sep-2016
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:1LZS: human lysozyme binds N-acetyl-D-glucosamine; contacts at 4A
  • Citation:PMID 7990138
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                     #      #    ###  ##                
1LMQ_A         1 KVYDRCELARALKAsgmdgyaGNSLPNWVCLSKWESSYNTQATNRNtd-gSTDYGIFQINSRYWCDDGRtpgakNVCGIR 79  rainbow trout
1LZS_A         1 KVFERCELARTLKRlgmdgyrGISLANWMCLAKWESGYNTRATNYNagdrSTDYGIFQINSRYWCNDGKtpgavNACHLS 80  human
EMP38935      19 KTYERCELARAMKRfgldgyrGYSLGHWVCTARYESNFNTGATNYNpgdqSTDYGILQINSRLWCNDGKtprtkNGCGIQ 98  green seaturtle
KFO33298       6 LLSLLCCLGAPSGArilgrctVARLLQERGLAYFESKFNPSAVYEDvqegVTGFGLFQIRDRERCEPGG-----NLCHVA 80  Fukomys damarensis
Q96KX0        20 YILGRCTVAKKLHDggldyfeGYSLENWVCLAYFESKFNPMAIYENtregYTGFGLFQMRGSDWCGDHGr----NRCHMS 95  human
O75951        20 SLISRCDLAQVLQLedldgfeGYSLSDWLCLAFVESKFNISKINENad-gSFDYGLFQINSHYWCNDYKsy-seNLCHVD 97  human
EPY80274      36 KVYSRCELARVLQDfgldgfrGYSLADWICLAYFASGFNTGAVDHEad-gSTNNGIFQINSRKWCKTLDss-gpNMCQMH 113 Wild Bactrian c...
XP_005312016  20 QVFSRCELARLLKRggldgfmGYRLDNWICLAFYASRFDTGTVTENsd-gSSDYGIFQINSRRWCSDQRsr-tlDLCQTR 97  western painted...
XP_007430877  21 KIFSRCELAAILRRwgmdgheGYGLDDWICLAYFASHFNTAAVTQNsd-gTSEYGIFQLNSRFWCADHHss-skNLCSLS 98  Burmese python
EMP26024     124 EVLSRCELARLLQRggldgfmGYRLDNWLCLAFYASRFNTGTVTENsd-gSSDYGIFQVNSRRWCSDQRsr-tlDLCQTR 201 green sea turtle

Feature 1                              #              #   ###                              
1LMQ_A        80 CSQLLTd-DLTVAIRCAKRVVLDp-------------NGIgAWVAWRLh---CQNq---------DLRSYVagC 127 rainbow trout
1LZS_A        81 CSALLQd-NIADAVACAKRVVRDp-------------QGIrAWVAWRNr---CQNr---------DVRQYVqgC 128 human
EMP38935      99 CRGVCTarYKSNFNTGATNYNPGdq----------stDYGiLQINSRLw---CNDg---------KTPRTKngC 150 green seaturtle
KFO33298      81 CSALLNl-NPKDTIKCAKKIVRGk-------------YGLgAWPSWSLh---CRFs--------dTLVRWLdgC 129 Fukomys damarensis
Q96KX0        96 CSALLNp-NLEKTIKCAKTIVKGk-------------EGMgAWPTWSRy---CQYs--------dTLARWLdgC 144 human
O75951        98 CQDLLNp-NLLAGIHCAKRIVSGa-------------RGMnNWVEWRLh---CSGr---------PLFYWLtgC 145 human
EPY80274     114 CFGALL--AIGLFDTDITEDTSD--------------GTPgNLGPWNLa---CRPr---------DASVTLeqG 159 Wild Bactrian camel
XP_005312016  98 CRDLLTa-DLVDDINCVKKVVMDw-------------QGMgVCQPPPVs---SIPll-------sPAARSLh-L 146 western painted turtle
XP_007430877  99 CRDLVTd-EIIDDIICVKRAVAGp-------------EGMaGEIIAVEe--tCIT----------GQLLVT--C 144 Burmese python
EMP26024     202 CRVRLPp-DPSPVGMGVLGLVTLlaclsaggrgkiftRCElAQELQENgmdgYEGyslanyllnpDIKDDIn-C 273 green sea turtle

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