3B84,2YY9


Conserved Protein Domain Family
BTB_POZ_ZBTB48_TZAP_KR3
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cd18232: BTB_POZ_ZBTB48_TZAP_KR3 
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BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.
Links
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Statistics
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PSSM-Id: 349541
Aligned: 8 rows
Threshold Bit Score: 156.842
Created: 13-Sep-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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homodimer
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:2YY9: Mus musculus KR3 BTB domain forms a dimer; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ###### ##  #     # #            # #  ##     #  #                         ## ##  
3B84_A         7 HSVRVLQELNKQREKGqYCDATLDVGGLVFKAHWSVLACCSHFFQSLYgdg--sgGSVVLPAgfAEIFGLLLDFFYTGHL 84  human
2YY9_A         8 HSVRVLQELNKQREKGqYCDATLDVGGLVFKAHWSVLACCSHFFQRIYgdg--tgGSVVLPAgfAEIFGLLLDFFYTGHL 85  house mouse
P10074         8 HSVRVLQELNKQREKGqYCDATLDVGGLVFKAHWSVLACCSHFFQSLYgdg--sgGSVVLPAgfAEIFGLLLDFFYTGHL 85  human
XP_007900312   8 HSKKILNALNKQREEGtFCDVTLDVEGRCLRAHRSILSCCSRFFHGVYrqg--msADLQLPQscTGVLALLFDFIYTGDL 85  elephant shark
XP_005994258   8 HSKKILQALNQQRAEGkFCDATLDVGGRSFRAHCGVLVCCSHFFHSIYgnvtpasVTVSLPEscSGAFELLLDFIYTGEL 87  coelacanth
NP_001038107   9 HSVRVLRELNRQRAAGqYCDATLGVGGREFRAHWPVLASCSRFFRSRGggg--gaGPVALPEglADTFQLLLDFFYTGRL 86  chicken
XP_002933897  44 HSVKVLSALNKQREEGrYCDATLVVGNFNFKAHWSILACSSPFFQSLYgdg--tsANIILHEsfSEVIGLVLDFLYTGEL 121 western clawed ...
OCT72812      17 HSVKVLNALNKQREEGrYCDATLVVGNVNFKAHWSILACSSPFFQSLYgdg--tsANIILHEsfAEVIGLVLDFLYTGEL 94  African clawed ...

Feature 1                                      
3B84_A        85 ALTsgNRDQVLLAARELRVPEAVELCQSFK 114 human
2YY9_A        86 ALTsgNRDQVLLAAKELRVPEAVELCQSFQ 115 house mouse
P10074        86 ALTsgNRDQVLLAARELRVPEAVELCQSFK 115 human
XP_007900312  86 RLTraNVCEVLSAAEELCIPDAVQMCRHYQ 115 elephant shark
XP_005994258  88 PLTreNLDRVLSAAKELAITDAVELCQRFQ 117 coelacanth
NP_001038107  87 ALTahNRARLLAAAELLGVPDAVALCRAFR 116 chicken
XP_002933897 122 ALTeeNVQKVLLTSKELEILEAIDVCERFQ 151 western clawed frog
OCT72812      95 ALTeeNVQKVLLASKDLEVLEAIEVCERFQ 124 African clawed frog

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