3DAL


Conserved Protein Domain Family
PR-SET_PRDM1

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cd19187: PR-SET_PRDM1 
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins
PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.
Statistics
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PSSM-Id: 380964
Aligned: 18 rows
Threshold Bit Score: 174.437
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activeputative SAMcatalytic
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             ###                #                                 ## ####
3DAL_A         54 ASLPRNLLFKYAtn----seEVIGVMSKEYIPKGTRFGPLIGEIYTndtv--------------------pknANRKYFW 109  human
NP_001251371   99 CTLPMNLILKSSsk----nrKKSSIWSSDHIPRGVRFGPLVGEIRLvdvdtalvcpaeasmagggpaqedvpfDEAPEEW 174  Caenorhabditi...
KPM10339       48 ATLPRNLILKPSkt----ikDVSGVWSTDYIPRGTRFGPLIGKIYAkdav--------------------pegASRKYFW 103  Sarcoptes sca...
EKC37668       50 ASLPRNLTLKPSqnq---vnNGLGVWSLDHIPRGTRFGPLVGEVFSrepy-------------------srkeTDRISLW 107  Pacific oyster
ACH72078       43 GTLPRNLYLKYNdq-----nEVLGVCSKEYIPQGTRFGPLVGQVYCrdev--------------------pkgANRKYFW 97   Florida lancelet
ABB58913       41 TSLPGNLRFKRRn------eQVVGVLADEYIPKGTRFGPLAGKIYReeev--------------------pedANKKYFW 94   purple urchin
EFX79494       50 TSLPRNLTLKSSqa----lsDVLGVWSSDYIPRGTRFGPLVGDIYAkdhv--------------------pkhANRKYFW 105  common water ...
NP_647982     120 KTLPRSLTLKSSmvystpnvKTEGVWSSGVIPRGTRFGPFEGIPTSnyp---------------------ndkNKARYFW 178  fruit fly
XP_006811492   66 ESLPQNLHFNKTdd----qsEIIGVYSNDFIPQGTRFGPLIGKKYNkdev--------------------kngANRKYFW 121  Saccoglossus ...
XP_013382596   38 ASLPRNLVLKPSqi----ftDVVGVWSTDYIPKGTRFGPLVGEIFTkdsi--------------------prtAEKKFLW 93   Lingula anatina
Feature 1         #                                                                               
3DAL_A        110 RIYsr--------------------------------------------------------------------------- 114  human
NP_001251371  175 KIYsps-------------------------------------------------------------------------- 180  Caenorhabditi...
KPM10339      104 RIYtnlyensdvnggknstqtkrlrkfqisttteeefcesdstisnankdefenvhhrtlidsdtekveksepsstsssa 183  Sarcoptes sca...
EKC37668      108 KVFkn--------------------------------------------------------------------------- 112  Pacific oyster
ACH72078       98 RVYdg--------------------------------------------------------------------------- 102  Florida lancelet
ABB58913       95 RIYng--------------------------------------------------------------------------- 99   purple urchin
EFX79494      106 RVYnn--------------------------------------------------------------------------- 110  common water ...
NP_647982     179 RIFkd--------------------------------------------------------------------------- 183  fruit fly
XP_006811492  122 RIYkd--------------------------------------------------------------------------- 126  Saccoglossus ...
XP_013382596   94 QVHhn--------------------------------------------------------------------------- 98   Lingula anatina
Feature 1                                                                       #            #####
3DAL_A        115 ---------------------------------------------------------geLHHFIDGfneeKSNWMRYVNP 137  human
NP_001251371  181 --------------------------------------------------------ggrLNKTICVkddaRSNWMKYVAA 204  Caenorhabditi...
KPM10339      184 distteicsstassvsrtkfnekiqsstvldsnlqydrtidnndsddefrhitepnrieDYFYIDGadpnESNWMRYVNP 263  Sarcoptes sca...
EKC37668      113 ---------------------------------------------------------nnVYQFLDNsdvtRSNWMHYTNF 135  Pacific oyster
ACH72078      103 ---------------------------------------------------------eeFQFYVDGyditKSNWMRYVNP 125  Florida lancelet
ABB58913      100 ---------------------------------------------------------qkFVHYIDGfnkkRSNWMQYVSP 122  purple urchin
EFX79494      111 ---------------------------------------------------------seVFYYIDGydtaKANWMRYVNP 133  common water ...
NP_647982     184 ----------------------------------------------------------dDYYYLDGsdrsQSNWMRYVAS 205  fruit fly
XP_006811492  127 ---------------------------------------------------------keFEFYIDGldvnESNWMRYVNP 149  Saccoglossus ...
XP_013382596   99 ---------------------------------------------------------hdLYLYVNIfdpkKSNWLRYVNS 121  Lingula anatina
Feature 1          #        ##                       ## ##  ##
3DAL_A        138 AHSPreQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 181  human
NP_001251371  205 AEEEdfQNLVAAQIGNDIYFYTVKKIEANTELSFWFSRDYARKL 248  Caenorhabditis elegans
KPM10339      264 AYSStaQNLVACQINREIYFYTIKPIPPDQELLVWYCREFAQRL 307  Sarcoptes scabiei
EKC37668      136 AYTAaqQNLIACQIDFNIYFYTTKPIPPNTELMVWYCREYADRL 179  Pacific oyster
ACH72078      126 AHSGeeQNLVACQHDMKIYFFTIKPVLPDTELLVWYCREFAERL 169  Florida lancelet
ABB58913      123 AGASaeQNIVACQYKTDIFFYTTKAVEPGQELFVWYCTEFAKRL 166  purple urchin
EFX79494      134 AYSSesQNLIACQYKMNIYFYTTKPILPNQELLVWYCKEFAERL 177  common water flea
NP_647982     206 AYSLsvMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 249  fruit fly
XP_006811492  150 AHTSdqQNLVACQNGMEVYFYTIKPIEKNAELLVWYCKEFAERL 193  Saccoglossus kowalevskii
XP_013382596  122 APSKqaQNIVVCQVDHAIYFYTVRPIPPDSELLFWYCQEFAERL 165  Lingula anatina

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