3DB5


Conserved Protein Domain Family
PR-SET_PRDM4

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cd19189: PR-SET_PRDM4 
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins
PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.
Statistics
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PSSM-Id: 380966
Aligned: 9 rows
Threshold Bit Score: 220.413
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activeputative SAMcatalytic
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             ###                #                   ####          #     
3DB5_A        16 RARLSLPKQLVLRQSi---vGAEVGVWTGETIPVRTCFGPLIGQQSHSXEVAEWtdkavnHIWKIYHNg-vLEFCIITTD 91   human
AAH43864     365 RARLSLPKELMLRQSv---tGAEMGVWAQESIPVRTCFGPLIGQESQSLEVADWtdksatHIWKMYHNg-vIEFCIITTD 440  African clawed...
NP_001116215 382 RARLSLPRPLCLRISv---tDEPIGVFSRESIPSRTCFGPMVGQHCSSVELTDWsdkdtpQIWKMFHNd-iQEFCIVTTD 457  zebrafish
KOF72257     489 RARLSTPSLLYLKTTsahgyTDTLGVWAKETVPCRSRFGPFVAKVKGKCPVDSQkts-dfPIWMIFSKdgqTADVLDVND 567  Octopus bimacu...
Q9UKN5       405 RARLSLPKQLVLRQSi---vGAEVGVWTGETIPVRTCFGPLIGQQSHSMEVAEWtdkavnHIWKIYHNg-vLEFCIITTD 480  human
ETE71390     406 RARLSLPKQLNIRHAv---mGPEVGVWTRETIPVRTCFGPLIGQQSHSVEVADWtdkaanHIWKMYHNn-vLEFYIITTD 481  king cobra
XP_006008265 392 RARLSLPRQLSLRQSi---tGAEIGVWTRETIPVRTCFGPLIGRQSHSVEVADWpdkmanHIWKMYHNs-aLEFCIITTD 467  coelacanth
XP_007903292 398 RARMSIPRQLSLRSSe---tGADVGVWCQETIPVRACFGPLIGQQSDPADVPDWsnknspDVWQIFGNy-vLESLLLVAD 473  elephant shark
XP_021354850 506 KARASLPTCLYLKSSet-ilQNVMGVWSKVPIKAKSKFGPLVGKVSSSAPGESKlgs-lpEFKVIYSD---KVDQYDLDD 580  Yesso scallop
Feature 1               ##### #        ##                       ##        
3DB5_A        92 EnECNWXXFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIG 148  human
AAH43864     441 EtECNWMMFVRKARNPEEQNLVAYPHDGKIYFCTSHDVSPEQELLFYYSRDYARQMG 497  African clawed frog
NP_001116215 458 EhECNWMMFVRKARTTGEQNLVAYIDNGKLYFCTTREILPDQELLFYFSRDYSRQLG 514  zebrafish
KOF72257     568 EnECNWMMFVKPARSSEEQNLVAYQQQHSIYFMTCCDVQPHQELLVWYSNDYASALG 624  Octopus bimaculoides
Q9UKN5       481 EnECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIG 537  human
ETE71390     482 EnECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYAQQIG 538  king cobra
XP_006008265 468 EnECNWMTFVRKARTREEQNLVAYPHEGKIYFCTSQELHPDQELLFYYSKDYARQIG 524  coelacanth
XP_007903292 474 EnVCNWMMFVRKARTQEEQNLVAYPHDGKIYFCTSREIPANQELLFYYTRDYARQLG 530  elephant shark
XP_021354850 581 EeECNWLKFVQMARTEESQNMVVTQMGSDIYFFTTKDVYPGEELLFWYSKDYARFLG 637  Yesso scallop

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