1ZXC,2A8H


Conserved Protein Domain Family
ZnMc_TACE_like

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cd04270: ZnMc_TACE_like 
Click on image for an interactive view with Cn3D
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
Statistics
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PSSM-Id: 239798
Aligned: 15 rows
Threshold Bit Score: 332.801
Created: 23-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
  • Structure:1ZXC: Human TACE coordinates Zinc

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1ZXC_B       9 NTCKLLVVADHRFYRYMGrge--------esTTTNYLIELIDRVDDIYRNTAwdna---------gfkgYGIQIEQIRIL 71   human
O14672     220 NTCQLYIQTDHLFFKYYGtr----------eAVIAQISSHVKAIDTIYQTTDfsg-----------irnISFMVKRIRIN 278  human
Q9VAC5     223 TRCPLLLVADYRFFQEMGggn--------tkTTINYLISLIDRVHKIYNDTVwqdrsd-----qegfkgMGFVIKKIVVH 289  fruit fly
Q8JIY1     220 NTCQLFIQTDHLFYKRYGet---------reAVIAQISSHVKAIDTIYQSTDfsg-----------irnISFMVKRIRIN 279  African clawed frog
CAH65250   221 NTCQLYIQTDHLFYKHYGtr----------eAVIAQISSHVKAIDTIYRSTDfsg-----------irnISFMVKRIRIN 279  chicken
AAH54638   225 NTCQLFIQTDHLFYKYYKtr----------eAVIAQISSHVKAIDAIYQGTDfmg-----------irnISFMVKRIRIN 283  zebrafish
XP_790625  100 HVCPMLLTADYRFYQSMGqsn--------mqISMNYLVSLVDRVDVIYKTTEwepg----------ysgFQFQIKKIVIH 161  purple urchin
AAB09097   187 NRCTLKLVADYSFYSIFGknn--------tgIVTKFLVNMIARVNEIYTPINwdvgkeddisgrgrfqnMGFSIKEIKVL 258  nematode
CAB09416   242 RTCSLYMQADHKLYEHIRmkegnndpirtreEIVSLFYNHIKAVNEIYEGTNfng-----------ikgLHFVIQRTSIY 310  nematode
NP_651716  479 TTCMLYLQADHTFFQKMGsd----------eASIEAITRHVQRANTIYRNTDfnndg--------kpdnITFMIKRIKVH 540  fruit fly
Feature 1                                                                                      
1ZXC_B      72 KSPQEVKPGEkhynm-aksyPNEEKDAWDv-KMLLEQFSFdiaeeaskvCLAHLFTYQDFDmg-tLGLAYVGSpr-anSH 147  human
O14672     279 TTADEKDPTNpf------rfPNIGVEKFL--ELNSEQNHDd-------yCLAYVFTDRDFDdg-vLGLAWVGAps--gSS 340  human
Q9VAC5     290 SEPTRLRGGEa--------hYNMIREKWDv-RNLLEVFSReysh--kdfCLAHLFTDLKFEgg-iLGLAYVGSpr-rnSV 356  fruit fly
Q8JIY1     280 VTSDEKDPTNpf------rfPNIGVEKFL--ELNSEQNHDd-------yCLAYVFTDRDFDdg-vLGLAWVGAps--gSS 341  African clawed frog
CAH65250   280 TTVDEKDPSNpf------rfPNIGVEKFL--ELNSEQNHDd-------yCLAYVFTDRDFDdg-vLGLAWVGAps--gSS 341  chicken
AAH54638   284 TTSDERDRSNpf------rfANIGVEKFL--ELNSEQNHDd-------yCLAYVFTDRDFDdg-vLGLAWVGApa--gSS 345  zebrafish
XP_790625  162 QNPSPTSADNynvd---rdsKPWGVQELLe-VYSKEDHSAf--------CLAHLFTYQDFSng-vLGLAYIGTpr-snAV 227  purple urchin
AAB09097   259 DRPNASDSHYns------ysRIWEVERLLreFAFAEGSKDf--------CLVHLVTARTFRevatLGLAYVSYkkwdeTA 324  nematode
CAB09416   311 TPDSCDRGRAktdsdnpfceENVDVSNFLn-LNSQRNHSAf--------CLAYALTFRDFVgg-tLGLAWVASpq-fnTA 379  nematode
NP_651716  541 NMNAMKDPSYrf-------pGNYGVEKFLe-LFSEEDYDAf--------CLAYMFTYRDFEmg-tLGLAWTGDl---kNA 600  fruit fly
Feature 1                                                        ##  #     #                   
1ZXC_B     148 GGVCPkayysp---vgkkniYLNSGLTSTknygk----tiltKEADLVTTHELGHNFGAEHDPdg------laECAPNed 214  human
O14672     341 GGICEksklys----dgkkkSLNTGIITVqnygs----hvppKVSHITFAHEVGHNFGSPHDSg--------tECTPGes 404  human
Q9VAC5     357 GGICTpeyfk-----ngytlYLNSGLSSSrnhyg---qrvitREADLVTAHEFGHNWGSEHDPdi-------pECSPSas 421  fruit fly
Q8JIY1     342 GGICErnklys----dgkkkSLNTGIITVqnygs----hvppKVSHITFAHEVGHNFGSPHDSg--------nECTPGea 405  African clawed frog
CAH65250   342 GGICEksklys----dgkkkSLNTGIITVqnygs----hvppKVSHITFAHEVGHNFGSPHDSg--------mECTPGes 405  chicken
AAH54638   346 GGICEknklys----dgkkkSLNTGIITVqnyas----hvppKVSHITFAHEVGHNFGSPHDSg--------sECTPGes 409  zebrafish
XP_790625  228 GGICTsvyyag----ngkrqYLNTGLTTTvnwgr----rvltEEADLVTAHELGHNFGSEHDPgne-----gdECAPGns 294  purple urchin
AAB09097   325 GGICSkqetf-----ngrvaYINVLLSTSfanseqstyplitKEIDIVVSHEYGHAWGATHDPtidsddpdveECSPNdq 399  nematode
CAB09416   380 GGICQvhqrynegsrgwvyrSLNTGIVTLvnygn----rvpaRVSQLTLAHEIGHNFGSPHDFp--------aECQPGlp 447  nematode
NP_651716  601 GGVCEknghy-----rgslkSLNTGIVTLlnygk----hvppAVSHVTLAHEIGHNFGSPHDPe---------QCTPGge 662  fruit fly
Feature 1                                                                               
1ZXC_B     215 ------qgGKYVMYPIAVsgdheNNKMFSQCSKQSIYKTIESK------------------AQECFQERSNKV 263  human
O14672     405 knlgqkenGNYIMYARATsgdklNNNKFSLCSIRNISQVLEKK------------------RNNCFVESGQPI 459  human
Q9VAC5     422 ------qgGSFLMYTYSVsgydvNNKKFSPCSLRSIRKVLQAK------------------SGRCFSEPEESF 470  fruit fly
Q8JIY1     406 knlgfkenGNFIMYARTTsgdklNNNKFSICSVRNISQVLDKK------------------ENSCFVESGQPI 460  African clawed frog
CAH65250   406 knlgqkenGNYIMYARATsgdklNNNKFSLCSIRNISQVLEKK------------------RNNCFVESGQPI 460  chicken
AAH54638   410 kspdkkerGNYIMYARATsgdklNNNKFSVCSIKNISQVLEKK------------------RGSCFVESGQPI 464  zebrafish
XP_790625  295 ------rgGNFLMYPASVtgsydNNRKFSICSKRLISPVLREK------------------SARCFVEPSQTS 343  purple urchin
AAB09097   400 ------ngGKYLMSQYAQkgydaNNVLFSPCSRKLIRDVLIGK------------------WESCFQEEMTSF 448  nematode
CAB09416   448 -------dGNFIMFASATsgdkpNNGKFSPCSVKNISAVLAVVlksmpvdptrnaspvgigKRNCFQERTSAF 513  nematode
NP_651716  663 -------dGNFIMFARATsgdkkNNNKFSTCSLKSIEPVLNAKar---------------sMKGCFTEPQSSI 713  fruit fly

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