3ELV,2JKD,3ELS,5LQW


Conserved Protein Domain Family
FHA_PML1-like
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cd22681: FHA_PML1-like 
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forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins
PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.
Links
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Statistics
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PSSM-Id: 438733
Aligned: 11 rows
Threshold Bit Score: 152.593
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphopeptide binding site [polypeptide binding site]
Evidence:
  • Comment:GR at the C terminus of strand beta3, SRxH just preceding beta5, and motif SxNG in the beta6-beta7 turn indicate a canonical mode of pThr recognition.
  • Comment:also based on structures of other FHA domains with bound phosphopeptide
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               ###                      
3ELV_A        61 SPDNYMDMLgleardrTMYELVIYRKNdkd--------kgpWKRYDLNGrsCYLVGRElghsldtd--lddrteivVADI 130 baker's yeast
2JKD_A        37 SPDNYMDMLgleardrTMYELVIYRKNdkd--------kgpWKRYDLNGrsCYLVGRElghsldtd--lddrteivVADI 106 baker's yeast
3ELS_A        14 SPDNYMDMLgleardrTMYELVIYRKNdkd--------kgpWKRYDLNGrsCYLVGRElghsldtd--lddrteivVADI 83  baker's yeast
5LQW_N        60 SPDNYMDMLgleardrTMYELVIYRKNdkd--------kgpWKRYDLNGrsCYLVGRElghsldtd--lddrteivVADI 129 baker's yeast
Q07930        60 SPDNYMDMLgleardrTMYELVIYRKNdkd--------kgpWKRYDLNGrsCYLVGRElghsldtd--lddrteivVADI 129 Saccharomyces c...
GAV46880      45 ACEPNTFYAktsigqrPLYKLMIYRDDs------------lVQEFELMEksSYIVGRAsge-------------tvVADI 99  Zygosaccharomyc...
XP_022466206  61 SPHQYWEATytppterQIFKAVLLNRKsk----------nvIAEYRLESqsCYLIGREvgshlpsnlpydtprqqfFCDI 130 Kazachstania na...
KTB01359      76 DAISPLDYFkgs-tdkTKYKCLLYKEStg----------kvIDEFELEAknSYLIGRKdeee----------eennIADI 134 [Candida] glabrata
XP_004180358  89 PEIYYSKYPts---seKIFKISIFKNTadsmkskdnvsekpIEEIELYDqkHYLIGRDkievened--tvkgkdivVADI 163 Tetrapisispora ...
OHS99815      42 KYFIPFDSTnp----dKSWHLFIFRDDe------------nEEEFEMTSp-TILIGREk-----------------FCDI 87  Tritrichomonas ...
XP_001326698  38 KYLLPFDSIepg--dkNLYYMHISVNNsd-----------dIITYDFKEp-ATLIGREh-----------------FCDI 86  Trichomonas vag...

Feature 1             #### #                           #  ##                                     
3ELV_A       131 GIPEETSSKQHCVIQFRNVR-------GILKCYVMDLDSS-NGTCLNNVVIPGARYIELRSGDVLTLSefeedndYELIF 202 baker's yeast
2JKD_A       107 GIPEETSSKQHCVIQFRNVR-------GILKCYVMDLDSS-NGTCLNNVVIPGARYIELRSGDVLTLSefeedndYELIF 178 baker's yeast
3ELS_A        84 GIPEETSSKQHCVIQFRNVR-------GILKCYVMDLDSS-NGTCLNNVVIPGARYIELRSGDVLTLSefeedndYELIF 155 baker's yeast
5LQW_N       130 GIPEETSSKQHCVIQFRNVR-------GILKCYVMDLDSS-NGTCLNNVVIPGARYIELRSGDVLTLSefeedndYELIF 201 baker's yeast
Q07930       130 GIPEETSSKQHCVIQFRNVR-------GILKCYVMDLDSS-NGTCLNNVVIPGARYIELRSGDVLTLSefeedndYELIF 201 Saccharomyces c...
GAV46880     100 PIEEDTCSKQHCVIQFRQQN-------GQLKAYLMDLESS-NSTTLNGDEIPSSHYVQLRPGDIISSLds----qYDLVF 167 Zygosaccharomyc...
XP_022466206 131 GVSDEGCSKQHCVIQFREKD-------SKLVPYIIDLDSV-NGTSLNESPLPKSRYVELHNKDIIYFSadatesaYELMF 202 Kazachstania na...
KTB01359     135 LIPEETCSQQHCVIQFRKTEn------DSIKAYIIDLESS-NGTVLNGNTIPQARYIELKNGDTIQFTadsrdrkYYLVY 207 [Candida] glabrata
XP_004180358 164 LLKDEKLAKQQCVLQFREIN-------GELKLYLMDLNCSkIDTLINDMVIPKSRYVELISGDVIVLNk------FEIVY 230 Tetrapisispora ...
OHS99815      88 ILKDATVSRQHCAIQFRLTKasesepkLITKPYIFDMSSK-GGTFINENVVPPMCFIELKPSDTISFAks----sENIVV 162 Tritrichomonas ...
XP_001326698  87 RFTHKIISRQHCVIQFRNVKanenqekLEITPYIFDMGTK-NGTYINDEQIPSCQYVQLLDGDIITFDkr---adNQIII 162 Trichomonas vag...

Feature 1         
3ELV_A       203 M 203 baker's yeast
2JKD_A       179 M 179 baker's yeast
3ELS_A       156 M 156 baker's yeast
5LQW_N       202 M 202 baker's yeast
Q07930       202 M 202 Saccharomyces cerevisiae S288C
GAV46880     168 M 168 Zygosaccharomyces rouxii
XP_022466206 203 L 203 Kazachstania naganishii CBS 8797
KTB01359     208 A 208 [Candida] glabrata
XP_004180358 231 V 231 Tetrapisispora blattae CBS 6284
OHS99815     163 M 163 Tritrichomonas foetus
XP_001326698 163 K 163 Trichomonas vaginalis G3

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