3IHX


Conserved Protein Domain Family
PR-SET_PRDM10
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cd19194: PR-SET_PRDM10 
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins
PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.
Links
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Statistics
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PSSM-Id: 380971
Aligned: 14 rows
Threshold Bit Score: 216.834
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activeputative SAMcatalytic
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             ##                #                                   #     
3IHX_A         16 RARASLPLVLYIDRF-----LGGVFSKRRIPKRTQFGPVEGPLVRgselkdcyihlkvsldkgdrkerdlheDLWFELSD 90   human
NP_001135541  243 RARASLPLVLYIDRF-----LGGVYSKRRIPKRTQFGPLEGPLVKktelkdsyihlkvalnspvdsegafqeDLWFELSE 317  western clawe...
A2BID7        168 KARASLPLVLYIDRF-----LGGVFTKRRIPKRTQFGPLEGPLVRqselldthihlkl-ymldpekegeraqDLWFDLSD 241  zebrafish
KOF94150      569 RAWSSLPPILQIFRLge-stELGVFAKRPIAKSTQFGPFIGEPVAnqnqltncrf-------vlmlerenneCFYIEMSD 640  Octopus bimac...
CEP16114      159 RAWASLPQHLQIFRLgd-stDLGVFAKRSIPRRTQFGPFIAELVEsrdmvtnkaf--------slqvereghKFYFEATD 229  Dumeril's cla...
PIK48769      450 RARATLPSMLQVFKVle--nDVGVFAKRALSKRTQFGPLEGAIVKdppntilk-----------wpverngeTVYIDCQD 516  Japanese sea ...
Q9NQV6        203 RARASLPLVLYIDRF-----LGGVFSKRRIPKRTQFGPVEGPLVRgselkdcyihlkvsldkgdrkerdlheDLWFELSD 277  human
EEN66076      231 KARASLPNQLFLAKSge-ttEHGVFTKRALPKRTQFGPVEAKLLKkeeipegtfllklqhktegeeqpddqpELYYDLTN 309  Florida lancelet
XP_023930001  730 RAWSSLPGMLQIFRIaddpnAIGVFAKKMVPKRTQFGPFVGELVPdmdsvtnkef-------plqlikadsqEMYFNTSD 802  Lingula anatina
XP_002731410  259 RARASLPNLLQIFKVdd--dKVGVFAKRAIPKKTQFGPIEGKLVSempaegmvw----------klqqedgsIAYFDLMD 326  Saccoglossus ...

Feature 1                ##### #        ##                       #         
3IHX_A         91 EtlCNWMMFVRPAQNHleQNLVAYQYGHHVYYTTIKNVEPKQELKVWYAASYAEFVN 147  human
NP_001135541  318 EslCNWMMFVRPAQNHleQNLVAYQYGQHIYFTTIKNIEPKQELKVWYAASYAEFVN 374  western clawed frog
A2BID7        242 EerCNWMMFVRPAQNHleQNLVAYQYGSDIFYTSIKNIQPKQELKVWYAASYAEFVN 298  zebrafish
KOF94150      641 EnkCNWMMFVRPAENFaeQNLVAYQHCQDIYFTVSKNIEPRQELKVWYAAHYAERIG 697  Octopus bimaculoides
CEP16114      230 EnkCNWMMFVRPAQSYdeQNLVAYQYGSEIYFCTTKHIQPRVELKVWYSAQYAERLG 286  Dumeril's clam worm
PIK48769      517 EfrSNWMGFVRPANSYseQNLMAFCLNNEIYFATIKTVEPRQELKVWYAKSFAEALG 573  Japanese sea cucumber
Q9NQV6        278 EtlCNWMMFVRPAQNHleQNLVAYQYGHHVYYTTIKNVEPKQELKVWYAASYAEFVN 334  human
EEN66076      310 EdeCDWMMFVKPAANHmeQNLVAYQHGNEIFYTTIKPVEPRQELKVWYSTSYASFMG 366  Florida lancelet
XP_023930001  803 EnkCNWMMFVRAAQNFkeQNCVVYQHGEDIFFSVTREIEPREELKVWYAAHYAEKLG 859  Lingula anatina
XP_002731410  327 EneCNWMMFVRPASCHseQNLIAYQNGGNLFFATIRTVDPKQELRIWYAASYAEFVG 383  Saccoglossus kowalevskii

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