2PPQ,1ZYL


Conserved Protein Domain Family
APH

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pfam01636: APH 
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Phosphotransferase enzyme family
This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.
Statistics
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PSSM-Id: 426359
Aligned: 142 rows
Threshold Bit Score: 51.733
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2PPQ_A  28 KGIAEGVENSNFLLHTTK-D---PLILTL------------------------YEKRv---EKNDL-PFFLGLXQHLAAK 75   Agrobacterium fabrum...
Q92YB2 107 RRLSSERDE-TFLFTRSDgR---DFILKI------------------------ANPAe---DAAAL-EFQDGALLHLEAA 154  Sinorhizobium meliloti
Q87UB0  37 KTLGSQQDR-NFLLETDK-R---RYVLKI------------------------CHGAy---STREL-MAQHAALQHLASH 83   Pseudomonas syringae...
Q92MC9  37 TELGSQQDR-NYRVDTSE-G---PFVLKI------------------------ARAEy---ARVEI-EAQNAALRHVATR 83   Sinorhizobium meliloti
Q7NEE2  28 VRLQIGQIQQTWRLETTA-G---RYICQS------------------------LHLA----FAKAVtEDAQAVSAYLRRQ 75   Gloeobacter violaceus
P73647  31 KPFGNGNINDTFLVDLDG-QtqtSFILQR------------------------INHQvfknPAAVM-GNMVRVTTHIKQK 84   Synechocystis sp. PC...
Q8YVD8  30 QAFGSGNINDTFLVTVDS-LeaqHFVLQR------------------------INTQ----VFRQP-ELIMQNMRIFSDH 79   Nostoc sp. PCC 7120
Q8EJU3  15 SALGNGHINDTLLVRWPT-G---ELVLQR------------------------INTQvfktPQALV-RNADKISHHLCAK 65   Shewanella oneidensis
Q89ZY1  21 KPLGAGLINDTYKVNTQE-AdapDYVLQRinhaifqnvemlqsniaavtghirKKLT----EAGEA-DIDRKVLSFLATE 94   Bacteroides thetaiot...
Q8G3W1  25 EPYGDGHINTTYLVTTDGp----RYILQQ------------------------MNTSi---FPDTV-NLMRNVELVTSTL 72   Bifidobacterium longum
2PPQ_A  76 GLscplP---------LPR-K-------Dge-lLGELSGR--------PAALISFleGXWLRKpea----------khcR 119  Agrobacterium fabrum...
Q92YB2 155 -Apv-vP---------VPRlV-------Rtk-sGEQSHTLstad-gprVMRLLTFlrGELQYRtpasea----qsrnvgR 210  Sinorhizobium meliloti
Q87UB0  84 RAv---S---------VPGvIrandtepLls-vDVDGQAV--------HVRLLEFidGQSLGHvghlshd---ivvglgE 139  Pseudomonas syringae...
Q92MC9  84 PDa--pK---------VPEvV-------Sa--lSGEEIVTaavreetyQFRLLTYldGTPLTRrrhlavetvaalgdvaG 143  Sinorhizobium meliloti
Q7NEE2  76 GF----V---------IPEfLtt----rAge-lHFEGEGG--------RWRVMTClpGVSHRTapdp---------vylR 120  Gloeobacter violaceus
P73647  85 LQrqplErp-----wlMPEvI-------Lt--kNNQDHWDsgt---geFWRAISFiaGSESFDiltdpaqa-kevgtalG 146  Synechocystis sp. PC...
Q8YVD8  80 -VhqrlQyappnrrweVPRvLstk-dnhDyc-tDTQGNF----------WRAISFisGSQSFdtmqdla----qaqeigY 142  Nostoc sp. PCC 7120
Q8EJU3  66 ALqq-qY---------GLQvV-------Spc-lTQEGELAidlg-eqgFWRAISYlpHSLSIevvksea----qaemaaK 122  Shewanella oneidensis
Q89ZY1  95 EG----------------KtY-------Wf---DGESYWR--------VMVFIPR--AKTYETvnpeysn---yageafG 135  Bacteroides thetaiot...
Q8G3W1  73 KA----Q---------GKEtL-------DivptTSGATWAeid---ggAWRVYKFieHTVSYNlvpnpdvf-reagsafG 128  Bifidobacterium longum
2PPQ_A 120 EVGKALAAXHLA-------SEGFEIKRpnALSVDGWKVLWDKseERADEVEKglREEIRP------EIDYLAAHWPK--- 183  Agrobacterium fabrum...
Q92YB2 211 ALAALGLGLEDYr------GRPPAGKLmwDISHTLDLTAVVd--HVAPERRA----QAEA------VLAEFERALPAit- 271  Sinorhizobium meliloti
Q87UB0 140 LCARVDLALADFe------HPGLERILqwDPRHAQALIKHLLp-VIKDADARacVIEAGEq-----AHRRLLPLIPS--- 204  Pseudomonas syringae...
Q92MC9 144 RLAVALRDF-DHpg----lERELQWDLrrAGPVALHLLSA----MSDVDLRKr-IAEAMVg-----AMRRVQPLMPD--- 205  Sinorhizobium meliloti
Q7NEE2 121 QAGQVAGKMHRL-------LAGFEHSFrfQLPNFHNTPQIHRq-LQACPCDS----KVEA------EWAYLLESVPAlll 182  Gloeobacter violaceus
P73647 147 IFHQLLSDLSPSq-----lVDTLPGFHhtPIYLQQYQRALAQnpKLTGSLGPe-INHCQRv-----IKTWLDQCGVLeta 215  Synechocystis sp. PC...
Q8YVD8 143 ALGMFHNLISDLspekladTLPGFHITplYLRHYEQVLATAKp-QPSPELDYclQFVSDRq-----SYACILENAKAa-- 214  Nostoc sp. PCC 7120
Q8EJU3 123 AFGHFACALSDFdateledVIPQFHHLpgRMEMLRQAVQQDKa-KRLESCRQw-VDYALSqqslldELAEISPQLP---- 196  Shewanella oneidensis
Q89ZY1 136 NFQAMLADIPETlg----eTIPDFHNMefRLKQLRDAVAANAa-GRVAEVQYy-LDEIEKr-----ADEMCKAERLFre- 203  Bacteroides thetaiot...
Q8G3W1 129 DFQNFLSEFDASql---teTIARFHDTphRFEDFKAALAADKl-GRAAACQP----EIDF------YLSHADQYAVVmdg 194  Bifidobacterium longum
2PPQ_A 184 ----DLPAGVIHADLFQDNVFFL-----GDELs--GLIDFYFACNDLLAYDVSICL----NA-WCFEKD--------GAY 239  Agrobacterium fabrum...
Q92YB2 272 ---gLKRRQIIHNDFNPHNVLLDps--sPTTVv--GIIDFGDMVHAPLINDLAVAL----SYhLGTENW--------AAR 332  Sinorhizobium meliloti
Q87UB0 205 -----LPIQAVHLDITEHNVVWLrdsqrQWQMq--GLIDFGDLVSTWRVADLSVTCaa-lLH--HAEGD--------PLY 266  Pseudomonas syringae...
Q92MC9 206 -----LRLQAIHQDVTDDNVVSRad--rSGRLipdGVIDFGDVLKGWVVADLAVTCasllHHaGGDPFQ--------ILP 270  Sinorhizobium meliloti
Q7NEE2 183 --paGLPRQIIHGDLKLTNFLFDe----rGGVv--GIVDLDTFMYHSLYVELGDAL----RS-WC-TAG--------ETF 240  Gloeobacter violaceus
P73647 216 kaqgQLPLRLMHGDPKVNNILFDrq---sGKAv--SVIDLDTTKPGLIHYDLGDCL----RS------G--------CNL 272  Synechocystis sp. PC...
Q8YVD8 215 ---gELPLRLMHGDPKINNIMFDtf-thKAVS----VIDLDTVKPGLVHYDIGDCL----RS-GCNPAGeetehwesVAF 281  Nostoc sp. PCC 7120
Q8EJU3 197 -------LRICHNDTKINNMLFDk---rDMSSm--AIIDLDTCMKGHLMYDFGDMVr---TFcSPEEED--------STA 253  Shewanella oneidensis
Q89ZY1 204 ---gKLPKRVCHCDTKVNNMMFDe----DGKVl--CVIDLDTVMPSFIFSDYGDFL-----R-TGANTG--------DED 260  Bacteroides thetaiot...
Q8G3W1 195 lrdgSIPLRVTHNDTKLNNILMDa---tTGKAr--AIIDLDTIMPGSMLFDFGDSI-----R-----FG--------AST 251  Bifidobacterium longum
2PPQ_A 240 NVTKGKALl-----------EGYQSVRP 256  Agrobacterium fabrum str. C58
Q92YB2 333 TGSFLEGFhsv-------raLEPGEIEV 353  Sinorhizobium meliloti
Q87UB0 267 ILPAIRAYh----------aLNPLKREE 284  Pseudomonas syringae pv. tomato
Q92MC9 271 AVKAFHAVc----------pLTDAELKA 288  Sinorhizobium meliloti
Q7NEE2 241 NLQLLEASl-----------SGYAQSGA 257  Gloeobacter violaceus
P73647 273 LGEETENWsa--------veFDLDLCRA 292  Synechocystis sp. PCC 6803
Q8YVD8 282 DTDLCQGIl----------qGYLSVAKE 299  Nostoc sp. PCC 7120
Q8EJU3 254 LENVKVRQsif-------aaICRGYLSE 274  Shewanella oneidensis
Q89ZY1 261 DKDLNRVN------------FNMEIFKA 276  Bacteroides thetaiotaomicron
Q8G3W1 252 ALEDEKDLskvhfstelfraYTEGFVGE 279  Bifidobacterium longum
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