Conserved Protein Domain Family
PRK05762

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PRK05762: PRK05762 
DNA polymerase II; Reviewed
Statistics
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PSSM-Id: 235595
Aligned: 201 rows
Threshold Bit Score: 671.951
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
83644404    4 PLKGFLLTRQWD-----DLVPeqerarGgltksLALQFWMLTDRGPVRLIVSDQYAVFF-----LESSAM--PVARRILT 71 
15922397    2 IDNFFILDFSYD-----VVEN------K-----PVIYIWAIDKEGNRVVLLEKKFRPYF-----YALVDD--NYNIDEIR 58 
70605924    2 LEDFFVLDFSYD-----VVDN------I-----PVIFIWSIDRRGNRVTLVEKNFRPYF-----YAVVDD--REDVSRVI 58 
16081956    2 EVEIRIVSASYR-----QSD-------------VAVELFGRTREGESVAALYFGFRPYY-----DVVEPD--EAYLKVIQ 56 
13541654    2 QVDIRIVSASYR-----QSD-------------VAVEIFGRSREGKSVSALFFGFKPYF-----DVVEPD--NEYLSSIR 56 
48477200    2 KIKMRLIAASYR-----QRD-------------VTVELYGRADDGSSVTALYFGFKPYF-----YYVNPD--EECIEKIK 56 
146304901   2 RVDIFILDFSYD-----VEDG------K-----PEIYIWGIDREGNRVVILEKSFRPYF-----YVTLKE--DANVNEAI 58 
282163715   2 TFDVRLLDSTYSvnqkdDGVS------E-----VIVKLFGKTRENKSITILCPDFKPYFhvfepSPALLKafKDSPDVLS 70 
289596990   7 YWDVRLLTASYS-----REED------G-----VVVELYGKTREGKSIVVRYKGFKPYF-----YLVEPP--STILEKFS 63 
119872473   2 ELKVWPLDITYA-----VVGS------V-----PEIRIFGILSSGERVVLIDRSFKPYF-----YVDCAVcePAALKTAL 60 
83644404   72 NLLGdssGERPPwyekeL-ELKDFG-------GQPVHGV--------YLREQRNLYRVRD--------MLMQ-------- 119
15922397   59 KEILklsKPYSP-----I-TSINVE-------EKKYFGS--------PVRVLKIETVIPA--------YVRVyrdevaki 109
70605924   59 SEIKklsKPSSPitnieIeTDRRYF-------GNPLKSLkietvvpaYVRIYRDEVSKIK--------GVKN-------- 115
16081956   57 NDPE-------------FvKMEDK--------RLWIRGK--------YENVKRIYIRSPW--------KVPEyr-----e 94 
13541654   57 NDDEyvkEEDKV-----L----------------WVHGS--------MHNVKRIYIRSPW--------KVPEyr-----r 94 
48477200   57 NNDEfisMEEKD-----L----------------FLNGE--------TVKTQKITVKSPW--------RVPElr-----k 94 
146304901  59 TQIKrlsRDQSP-----I-TSVTEH-------EMKYFGR--------PQKVLRVETVIPA--------LVRTyreeiakl 109
282163715  71 VEDVtleYKGSQekfakVsVRAPWM-------VPKFRGQ--------YELKHKTITLVDPpeelveklRAEPdvlevsvl 135
289596990  64 QDPE-------------IyKMEEVElwhkgkvRKCVKVT--------LHSPWKTPRYRRE--------ALEF-------- 106
119872473  61 -------SRVAP-----I-DDVQIV-------ERRFLGR--------SKKFLKVIAKIPE--------DVRKlreaamsi 104
83644404  120 -AGLAP-----------------------------------MEADIHPTDRFLMERFVTGSMVVHGEAVek-----dgVL 158
15922397  110 kGVKSV-----------------------------------LEADIRFYMRYSIDNNLKPFYWIEAEVE----------- 143
70605924  116 -----V-----------------------------------LEADIRFYMRYSIDKGIKPFYWIKADVEeiq---pkeIF 152
16081956   95 kCPFEV-----------------------------------LAADIPFHHRFIYDLDLGSCVKIIGENIsdretsfttDI 139
13541654   95 rCPFEV-----------------------------------LAADIPFHHRFIYDFDLGACVRITGEDIsgtegnfttDL 139
48477200   95 iCKCQA-----------------------------------LAADIPFHHRFIYDFDLGSSLEIEGDELdderinystDH 139
146304901 110 kPVKDV-----------------------------------LEADIRFYMRYSIDTGVRPFYWLSAEVS----------- 143
282163715 136 nGGVKVstedrvysqklinrygliaymdeedaekfhtkgvfFAADIVFTNRFIYDHDLETCVRVSGDLMersn-eyttDL 214
289596990 107 ---CDV-----------------------------------LAADIPFHQRFIYDFDLGSCVRVYGKEEekgk--yttEL 146
119872473 105 pRVSGV-----------------------------------YEADIRFYMRYMIDMGVVPCSWNVAEVE----------- 138
83644404  159 EFHNPRIKPAP-Y------------A-PYFKVLSLDIE-------TSMDGaQLYSIGLaatsygadvgaGAMQH---RVF 214
15922397  144 EIKENNFRVKKvYelkkin-klyedKiPELKVLAFDIE-------VYNKy-------------------GSPNPrrdPVI 196
70605924  153 KVKSEKLYLIKdile------iyeaEePRLKTMAFSIEvynkygfPNTRRdPIIVIGV---------------------- 204
16081956  140 VIRADRIENVNdF------------N-PNLKVLSFDVEneinrenVEDYG-KILVIGY-------------------SVS 186
13541654  140 VLKIDKIENIPdF------------N-VNLKVLSFDVEneinrenVEDYG-KILVIGY--------------------SI 185
48477200  140 VIKIKNIKNTEaF------------N-PDLKILSFDVE-------NSIKTkEIYVIGY-------------------AIY 180
146304901 144 QVERKDLRVAKvYelkrie-rvyedSpPQLRFMAFDIE-------VFNKy-------------------GFPNPrrdPII 196
282163715 215 LLKASRFEKCDiF------------T-PKLKILSFDIE-------SSIKYnNIYCICLt---------vINEED------ 259
289596990 147 VVNAEKFENIGdF------------K-PPLKILSFDIE-------NSMKNgRIFTIGI-------------------AIW 187
119872473 139 --EGGRLGGIPtYvvsqwygidegfP-PSLKVMAFDIE-------VYNER-------------------GSPDPirdPVV 189
83644404  215 MVGENAEd--sPDY---------------LVYCADESEVFRRFVEWFDGFDPDILIGWNVINFDLRFLQKKADEL----- 272
15922397  197 IIGVWTKeg-gKQF---------------LADKYDDLRAIREFINFVQTYDPDIIVGYNINNFDWPYLLERANIR----- 255
70605924  205 --YTENGy---KQF---------------ISSDYDDINVIREFIKFVNDFEPDIIFGYNSNSFDWRYLVERAELR----- 259
16081956  187 FQGKTVT----------------------GSLSGEEQDILRSFVDLIRAEDPDVITGYNIDGYDIPVIKKRMDRY----- 239
13541654  186 MFGDIQKk---------------------GEIHGDEKEILYRFIDLIRAEDPDVITGYNIDGYDMLVIQRRMEQY----- 239
48477200  181 FNNKIET----------------------GSITGTEHEILKKFNELIINNDPDIITGYNIDGYDLPLIEERMKYN----- 233
146304901 197 VIGVWTDng-sKQF---------------VNNDQDDLKILRDFSKFVVEYDPDVILGYNSNGFDWQYMLERASVR----- 255
282163715 260 --GSRQDr---RIFsefgarelkisaeeqKARDEDERRILKEFVREVRALDPDVITGYNINNFDLAVLFERANKLfgkgg 334
289596990 188 ENGEIRK----------------------ESIEGDEKDILWKFLEMIWKEDPDIITGYNIDGYDLELLSERYKKY----- 240
119872473 190 MLAIKTNdgheEVF---------------EASGKDDRGVVRAFVDFIRSYDPDVIVGYNSNGFDWPYLVERAKAV----- 249
83644404  273 NFP-----------FHPGRGGAAMDWRqSRSDDQHFTLCIPGRVVLDGIDT--------LKSATYNFESFSLEYVAQHLL 333
15922397  256 GIR-----------LDVGRRVNG-----EPSQGVYGHYSITGRLNVDLYGFaqsiqevkVKTLENIADYLGVLPKEKRTI 319
70605924  260 GIK-----------VAIGRKVNS-----EPSQGVYGHYSVTGRLNVDLAGVfcs---srSKSLIDLADNLGVMPKNKREI 320
16081956  240 GIK-----------LEIGRDGSI------PRRIMNQFWRVHGRLISDTWWS--------VKRILHP-KHESLDYVANMLL 293
13541654  240 GIH-----------LNLGRDGSV------PRRIMDQFWRVHGRLISDTWWN--------VKKILHP-KHESLDYIAMKLL 293
48477200  234 NIK-----------FGIGRDHLP------PKRILDQYWRLHGRVVSDAWWA--------VKKVV-KPKHETLNYVARLLL 287
146304901 256 GTK-----------LDIGRKVNS-----EPSQGTYGHYSVVGRLNVDLYGFaeslegvkVKSLDNVADYLGILPKNKRTN 319
282163715 335 GKPdeekkrqsndeLGFGRDTLGMSRR-ENRTTGFVTWDVKGRLILDGWLS--------VKKELRP-KREGLGYVSTMLF 404
289596990 241 GMD-----------FLIGRDKSK------PQRIVGQFWRLHGRVIEDAWWA--------VKKEL-RLKQETLQAVAMHLF 294
119872473 250 GVP-----------LKVDRLSNP------PQQSVYGHWSIVGRANVDLYNIveefpeikLKTLDRVAEYFGVMKREERVL 312
83644404  334 GRGKLI----HDPdNRGDEITHLFLHDKPRLAAYNLEDCQLVWEIFQ--HALLIEFAVERAQLTGLALDRFGGSVASF-- 405
15922397  320 VEWYDIpkywDDE------------KKRDILLKYNLDDAKSAYLLGE----VFIPFGIELTRISGLPLDQLSMASVGHrv 383
70605924  321 LEWYEVprywDDK------------SKREILLKHNLSNIKSIYDI----GQSNLHYLIQLVKVTGLPLDQLSMASSGHri 384
16081956  294 GEGKDNi-------DRLH-IEDEWKKRREEVIAYCIKDADLTLRIFE--KLMVMNRLMYMSSVTKLPLDDVANVGTSNyv 363
13541654  294 GEGKDSi-------DRLN-IEAEWQKRQDEVISYCIKDADLTLRIFE--KLRVLERLMFMSTVTKLPLDDVANAGTSNyv 363
48477200  288 NDEKENi-------DRIN-IESEWEAKKEDVIKYCIKDAYLALEIYR--KIRILDMNLYLSAVSKLPLDDVANGGTSTyv 357
146304901 320 LEWYQIpeywEDP------------KRREVVLKYNLDDVKTTYLL----RDVFFNFGEQLTVISGLPLDQLCMASVGHrv 383
282163715 405 NDTKDN----IDS----SHMDDEWQARKDEVIHYCLKDADLALRILThpRIQAISKLMDVAIPAKLPVKEVSGGQNRMi- 475
289596990 295 GEGKLDv-------DRTN-IDEEWEKDKEKVIEYCKKDAELALRILL--QIGIINKYLDLATVTKFPLEDVIHSGTSTwv 364
119872473 313 IPGHKIyeywKDP------------NKRPLLKRYVLDDVRSTLGLAD----KLLPFLIQLSSVSGLPLDQVAAASVGNrv 376
83644404  406 DNRYLPRLHRAGYVAPMLPQNPvGVGSPGGYVMDSIPGLYRNVLVLDFKSLYPSIIRTFKIDPLARI-RGIE--IErgqd 482
15922397  384 EWLLMREAYKYNELIPNKEERE-YESYEGGLVISPLPGIHEDVYVLDFSSMYPSIMIKYNIGPDTLV-KG---------- 451
70605924  385 EWLLVRESKKYNEFIPNREERR-TEASDEGIIVPPVSGLHNNVYMLDFSTIYPSIILKYNISPDTLV-RGDC-------- 454
16081956  364 DSILIRAADRENIGVPMNQHEIkTEEIQGGYVHSIGAGLYSNVIVLDFKSMYPSMIIKYNVCFTTLD------------- 430
13541654  364 DSILIRAADRENIGVPMNAHNLkEDEIQGGYVHTIGAGLYSNVIVLDFKSMYPSMIIKYNVCFTTL-----D-------- 430
48477200  358 DSILIREADKQNIAVPMSAHDFkEESFEGGYVHSIGAGLYDMVIVLDFKSMYPSMIIKYNICFTTLNrNGT--------- 428
146304901 384 EWLLMRQAKQFNELIPNRVERR-YEGYKGGLVIEPKPGLHENVAVLDFSSMYPSIMIKYNIGPDTLV-QGE--------- 452
282163715 476 ESLLIRMVDREKVAVPMSSGEV--YDYEGGFVYDTKPGLWEWVIGLDFSSMYPSQVIKHNICFTSFT-------KN---- 542
289596990 365 DSLLIREADRHNIGVPLQGQERkSRKIEGGYVHTIEPGLYHWVCVLDFKSMYPSIIIKYNICFTTLS------------- 431
119872473 377 EWMLLRYAYRLGEVAPNREERE-YEPYKGAIVLEPKPGMYEDVLVLDFSSMYPNIMMKYNLSPDTYL-EPGEpdPPeg-- 452
83644404  483 vlredlwdqqetvkvDRKRlVPGFNGAVF---SK-DHNILPDII----------GELWAARDEAKRHKNA---------- 538
15922397  452 ---------------ECENcWISPAGHKF---RKdPPGLYKNVL----------EKLIQERKEVKKLMEKtmdeyd---k 500
70605924  455 ----------------SDCwTSLNGNYKF---RKdIKGLYQNVLlnlsaeierrEEIIKTLDPEKRRRLE---------- 505
16081956  431 ---------------PNGE-ILSPNGVRFlspEK-KKGLIPRIL----------QELMADRDEVKRRMKAaktkde---r 480
13541654  431 ---------------PKGE-IVSPTGIRFlspEK-KKGLIPRIL----------QELMADRDDVKKRMKEaksede---r 480
48477200  429 --------------------IVAPNGARFlspDI-KKGLIPSML----------ESLMKDRDNIKKQMKSssgee----k 473
146304901 453 ---------------CNDCwVAPEVGYKF---RKdVDGFYRSIL----------NFLLEERRKTKDQMSQakdeye---k 501
282163715 543 ---------------KAEAaHTSPVGAMFlptEK-RHGIVPRMV----------EGLLTSRKQAKAAMKKakeegnleqa 596
289596990 432 ---------------KDGD-IVSPTGVRFlskEK-REGLIPKLL----------AELMKKRDELKRKMKEdpdnr----- 479
119872473 453 ------------------vnVAPEVGHRF---RRsPPGFVPQVL----------KSLVELRKAVREEAKKyppdsp--ef 499
83644404  539 ----AMSQAIKILMNSFYGVLGTPGCRFF-DHRLPSSITLRGHRILYRTKELIEQQGHQVIYGDTDSVFVWLKehKQSAA 613
15922397  501 rvldARQRALKVMANAFYGYMGWLGARWY-SKEGAEAVTAWGRQIISESAKIAKEKGFTVIYGDTDSIFVKGGgdI---- 575
70605924  506 ----EELRALRSILNSFYDYIRWTNARWY-VKECAEGLFEWGRELILQILKIVKESGFQVIYADTDLMF-------FKGE 573
16081956  481 efydGIQNAIKVLMNTFYGVLASSFYRFT-DHKIGSAITAFARETIKGIISTLESAHYRVIYGDTDSVFVESG---AGSA 556
13541654  481 lfydGIQNAIKVLMNTFYGVLASSFYRFT-DPKIGSAITAFARETIKHIIDVLESSGHRVIYGDTDSVFVESG---DVRQ 556
48477200  474 eylnGLQNAIKVLMNTFYGVLGASFYRFT-NPEIGGAITSLGRVTIKNIIDKLESSGHRVIYGDTDSIFIESG---KKTK 549
146304901 502 rrldERQRALKIMANAMYGYMGWLGARWY-SKEGAEAVTAWGRQTIMTAAEIAKNSGFEVIYGDTDSIFV------KGDM 574
282163715 597 dyynRLQNAIKIMANATYGYFGTKFCRWPyNRYIAPSITAWARDEIKTVVTTLESRGYTVIAGDTDSVFFTSK--EHRDL 674
289596990 480 dyynGLQKAVKILMNTFYGVLASSFYRFT-NPDIGASITAFARDTIKRIIAELESEGIKVVYGDTDSVFFQSP---YEDL 555
119872473 500 kildERQRALKVMANAIYGYLGWVGARWY-KREVAESVTAFARAILKDVIEQARRLGIVVVYGDTDSLFV-----KKHGD 573
83644404  614 AEIDSVGKQLAATLNQWWRDYLMQEYGIESFLEIQFETHFLRFVMPtirgsekGSKKRYAGLAa-RGEGEPEMVFKGLET 692
15922397  576 -------------------NSLITEISSKFGLEIKIDKIYKRVFFT-------ENKKRYAGLT-----EDGKIDIVGFEA 624
70605924  574 NDPKKLEEDIANRLS----------------LNLKFNKFYTKLILL-------EGKKQYAALT-----KDNKVDMVGIED 625
16081956  557 EDAIKRGKDLSERLSR------------EQGLTLDFQMVLDPFFSH-------GAKKRYAGRCvyPDDMKGEIVIKGYEV 617
13541654  557 EDAIKTGKELSQKLSE------------EEGLTLDFQMVLDPFFSH-------GAKKRYAGKCvyPEDMKGEIIIKGYEV 617
48477200  550 EDAIKFGNELSDRISK------------EENLVLEFEKIMDPLFSH-------GAKKRYAGKViyPDSMAGEILVRGYET 610
146304901 575 SSVELLTQKIVQALD----------------LDIKVDKKYKKVFFT-------ENKKRYAGLT-----FDGKIDIVGFEA 626
282163715 675 EKCKLLGFTVQQEFS-------------AGNMHLELEKVMIRFFA--------HAKKRYFGKIiw---peESLLVRGYEP 730
289596990 556 ENTIEFGMRKAEEISR------------REKLILEFEKILEPFFSH-------GAKKRYVGRIiwPDEEKGNMVVRGYEI 616
119872473 574 VD------KLIKYVEEKYG------------IDIKVDKDYAKVLFT-------EAKKRYAGLL-----RDGRIDIVGFEV 623
83644404  693 VRTDWTPLARTFQKELYRRIFHNEPY-------EDYVRDLVSDIRAGK--KD-DLLYYRKRLRRRLDEYQ-RNVPPHVQA 761
15922397  625 VRGDWCDLAKQVQTNVIELILKSGKVed----aIKYVKTVIFDLRRYN--FRiEDLIIWKTIDKNLDEYD--VTAPHVVA 696
70605924  626 YRNNWCDLAKEVLQNVVDQVLRSDKIne----aVRYVKSVIYSLRRGE--FKiEDLVTWNIIDKDIEEYK--FDLPHIVA 697
16081956  618 RRTDSFDLQSQALSKVIDFILNRDIDg-----aIKYADDLIKKVRAGDpsIDiDSLVISRTVKDFQSYRAnQESLANIRA 692
13541654  618 RRTDSFDLQSTALSKVIDFILDRDVQg-----aINYADDLVKKVRNGDpsIDiESLVISRTVKDFSSYKAnTDSLANIRA 692
48477200  611 RRTDSFDLQSEALSKVFEYILNRDVDg-----aKRYADELVTKLKNGDnsIPiEKLVISRTV-KNFKSYKnADSMANVAA 684
146304901 627 IRGDWCELAKDTQRMVIERILLKGVDd-----aVKAAKEVIMKVKRRE--FElHDIVIWKSLDKSLDEYE--VDAPHVIA 697
282163715 731 RRTDSFDLQSETMTKVFQLVLDGKPEe-----aVNYAKDTVHDTIKGK--VDlPRLVISKSV-NEFDSYDnPGSLVHVNV 802
289596990 617 RRTDSFDLQSEAQRAVFEKILDGDIQg-----aIELAREIVSKVRAGK--VPiESLVISRTVKDFKFYKn-PDSMPNVQA 688
119872473 624 VRGDWSELAKDVQLRVIEIILKSRDIvearhgvIKYIREIIERLKNYK--FNiDDLIIWKTLDKELDEYK--AYPPHVHA 699
83644404  762 ARTADRIREEqglppryqrgGWIEYVVTVNGPEPLEYR---------RSALDYDLYVERQIEPIADGILRFM----NASF 828
15922397  697 AKKAAKAGYLvs------kgVKIGYVI-VKGSGKISDKaepyflikeKNKIDVEYYIDKQIIPVAMRILEGF----GVKE 765
70605924  698 ARKAMKSGHLvt------rgSKIGYVI-VKGSGKLSNRaepyfmvkeKSKVDIEYYIDKQIIPSALKVLGLF----GVKE 766
16081956  693 AKKLIDMGETfv------pgMKVSWIVTNGKRTPQEVEpyiy-grdlNVKPDWDYY-ARRLSETLGRVIDVF----RTDL 760
13541654  693 ARKLIERGETfv------pgMKVSWIVTNGKKTPQEVEpyiy-gsklESKPDWDYY-AKRLSETLNRVIDVFr---KDMV 761
48477200  685 ARKLIAMGETfi------pgMKVSWIVTNANKTPQEVEpyidgepfnKRP-DYDYY-SRRLQETLNRVLEGL----NKEI 752
146304901 698 AKKAINAGYAim------rnGKIGYVV-VKGAGRVSDRvepyfmvkdKTKIDIDYYVEKQIIPAVMRILEPF----GVKE 766
282163715 803 AKKLQEMGYDft------pgMKTPFIITNGSAQPQKAEpvie-gvqfTARPDYKYYAERLAMALARITEPFG----CDER 871
289596990 689 ARKLIKMGQEfi------pgMKVAWIVVNARGSKQDVEpyip-gmefNRKPDYRYY-ARRVAETLARITDVFgvdeENLL 760
119872473 700 AQILKRHGYRvg------kgTTIGYVI-VKGGEKVSERalpyillddIKKIDIDYYIERQIIPAALRIAEVI----GVKE 768
83644404  829 QDIS-----GGQIGLF 839
15922397  766 SSLK-----TGGVDIL 776
70605924  767 NTFK-----FGGTDVL 777
16081956  761 GQGQk----TASLESF 772
13541654  762 QGNR-----ISSLDSF 772
48477200  753 KVNK-----NPQTRLD 763
146304901 767 NNLK-----GGGIDIM 777
282163715 872 ALIQgn--sQRSLEFF 885
289596990 761 TGSR-----QISLGAF 771
119872473 769 SDLKtgrmeRSLLDFL 784
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