2VSM,2X9M,2VSK,2X9M,3D12,3D11,2VWD


Conserved Protein Domain Family
HeV-G

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cd15468: HeV-G 
Click on image for an interactive view with Cn3D
Glycoprotein G, or hemagglutinin-neuraminidase of Hendravirus and Nipah virus
The glycoprotein (G) of Nendravirus and Nipah virus has a variety of functions during viral infection; it participates in virus attachment to host cells and has a stimulating effect on membrane fusion during the entry of the virus into the host cell. This models characterizes the globular ectodomain of glycoprotein G. The receptors for Hendravirus and Nipah virus have been identified as ephrin B2 (EFNB2) and ephrin B3 (EFNB3).
Statistics
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PSSM-Id: 271232
Aligned: 9 rows
Threshold Bit Score: 661.545
Created: 8-May-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 33 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site [polypeptide binding site]
Evidence:
  • Structure:2VSM: Nipah virus hemagglutinin-neuraminidase binds its receptor ephrin B2, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                        ####                         
2VSM_A      1 ICLQKTSNQILKPKLISYTLPVVGqSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFM 80  Nipah virus
2X9M_B      4 ICLQKTTSTILKPRLISYTLPINTrEGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFM 83  Hendra virus
2VSK_A      1 ICLQKTTSTILKPRLISYTLPINTrEGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFM 80  Hendra virus
2X9M_A      4 ICLQKTTSTILKPRLISYTLPINTrEGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFM 83  Hendra virus
3D12_A     13 ICLQKTSNQILKPKLISYTLPVVGqSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFM 92  Nipah virus
3D11_A     13 ICLQKTSNQILKPKLISYTLPVVGqSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFM 92  Nipah virus
2VWD_A      6 ICLQKTSNQILKPKLISYTLPVVGqSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFM 85  Nipah virus
AFH96011  204 PCRNFSSVPTIYYYRIPGLYNRTAlDERCILNPRLTISSTKFAYVHSEYDKNCTRGFKYYELMTFGEILEGPEKEPRMFS 283 Bat Paramyxovirus ...
AFP87279  211 FCKSVSKDPDFRLKQIDYVIPVQQdRSICMNNPLLDISDGFFTYIHYEGINSCKKSDSFKVLLSHGEIVDRGDYRPSLYL 290 Cedar virus
Feature 1                                          #                                          
2VSM_A     81 TNVWTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKsn--gGGYNQHQLALRsiekgrY 158 Nipah virus
2X9M_B     84 TNVWTPPNPSTIHHCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKsd--sGDYNQKYIAITkvergkY 161 Hendra virus
2VSK_A     81 TNVWTPPNPSTIHHCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKsd--sGDYNQKYIAITkvergkY 158 Hendra virus
2X9M_A     84 TNVWTPPNPSTIHHCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKsd--sGDYNQKYIAITkvergkY 161 Hendra virus
3D12_A     93 TNVWTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKsn--gGGYNQHQLALRsiekgrY 170 Nipah virus
3D11_A     93 TNVWTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKsn--gGGYNQHQLALRsiekgrY 170 Nipah virus
2VWD_A     86 TNVWTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKsn--gGGYNQHQLALRsiekgrY 163 Nipah virus
AFH96011  284 RSFYSPTNAVNYHSCTPIVTVNEGYFLCLECTSSDPLYKANLSNSTFHLVILRHNKD-----EKIVSMPSFNLstd-qeY 357 Bat Paramyxovirus ...
AFP87279  291 LSSHYHPYSMQVINCVPVTCNQSSFVFCHISNNTKTLDNSDYSSDEYYITYFNGIDRpktkkIPINNMTADNR------Y 364 Cedar virus
Feature 1                                                 ##           ##                     
2VSM_A    159 DKVMPYGPSGIKQGDTLYFPAVGFLVRt--eFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGEN 236 Nipah virus
2X9M_B    162 DKVMPYGPSGIKQGDTLYFPAVGFLPRt--eFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSLGGD 239 Hendra virus
2VSK_A    159 DKVMPYGPSGIKQGDTLYFPAVGFLPRt--eFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSLGGD 236 Hendra virus
2X9M_A    162 DKVMPYGPSGIKQGDTLYFPAVGFLPRt--eFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSLGGD 239 Hendra virus
3D12_A    171 DKVMPYGPSGIKQGDTLYFPAVGFLVRt--eFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGEN 248 Nipah virus
3D11_A    171 DKVMPYGPSGIKQGDTLYFPAVGFLVRt--eFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGEN 248 Nipah virus
2VWD_A    164 DKVMPYGPSGIKQGDTLYFPAVGFLVRt--eFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGEN 241 Nipah virus
AFH96011  358 VQIIPAEGGGTAESGNLYFPCIGRLLH----KRVTHPLCKKSNCSRTDDESCLKSYYNQGSPQHQVVNCLIRIRNAQRDN 433 Bat Paramyxovirus ...
AFP87279  365 IHFTFSGGGGVCLGEEFIIPVTTVINTdvftHDYCESFNCSVQTGKSLKEICSESLRSPTNSSRYNLNGIMIISQNNMTD 444 Cedar virus
Feature 1                                       #                             #####        #  
2VSM_A    237 PKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEIC 316 Nipah virus
2X9M_B    240 IILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQSQCPRFNVCPEVC 319 Hendra virus
2VSK_A    237 IILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQSQCPRFNVCPEVC 316 Hendra virus
2X9M_A    240 IILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQSQCPRFNVCPEVC 319 Hendra virus
3D12_A    249 PKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEIC 328 Nipah virus
3D11_A    249 PKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEIC 328 Nipah virus
2VWD_A    242 PKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEIC 321 Nipah virus
AFH96011  434 PTWDVITVDLTNTYPGSRSRIFGSFSKPMLYQSSVSWHTLLQVAEITDLDKYQLDWLDTPYISRPGGSECPFGNYCPTVC 513 Bat Paramyxovirus ...
AFP87279  445 FKIQLNGITYNKLSFGSPGRLSKTLGQVLYYQSSMSWDTYLKAGFVEKWKPFTPNWMNNTVISRPNQGNCPRYHKCPEIC 524 Cedar virus
Feature 1     ####                      ####                     # ###                   ### #
2VSM_A    317 WEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDT 396 Nipah virus
2X9M_B    320 WEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQKTITDCFLLENVIWCISLVEIYDT 399 Hendra virus
2VSK_A    317 WEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQKTITDCFLLENVIWCISLVEIYDT 396 Hendra virus
2X9M_A    320 WEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQKTITDCFLLENVIWCISLVEIYDT 399 Hendra virus
3D12_A    329 WEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDT 408 Nipah virus
3D11_A    329 WEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDT 408 Nipah virus
2VWD_A    322 WEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDT 401 Nipah virus
AFH96011  514 WEGTYNDVYSLTPNNDLFVTVYLKSEQVAENPYFAIFSRDQILKEFPLDAWISSARTTTISCFMFNNEIWCIAALEITRL 593 Bat Paramyxovirus ...
AFP87279  525 YGGTYNDIAPLDLGKDMYVSVILDSDQLAENPEITVFNSTTILYKERVSKDELNTRSTTTSCFLFLDEPWCISVLETNRF 604 Cedar virus
Feature 1         #             
2VSM_A    397 GDNVIRPKLFAVKIPEQC 414 Nipah virus
2X9M_B    400 GDSVIRPKLFAVKIPAQC 417 Hendra virus
2VSK_A    397 GDSVIRPKLFAVKIPAQC 414 Hendra virus
2X9M_A    400 GDSVIRPKLFAVKIPAQC 417 Hendra virus
3D12_A    409 GDNVIRPKLFAVKIPEQC 426 Nipah virus
3D11_A    409 GDNVIRPKLFAVKIPEQC 426 Nipah virus
2VWD_A    402 GDNVIRPKLFAVKIPEQC 419 Nipah virus
AFH96011  594 NDDIIRPIYYSFWLPTDC 611 Bat Paramyxovirus Eid_hel/GH-M74a/GHA/2009
AFP87279  605 NGKSIRPEIYSYKIPKYC 622 Cedar virus

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