3MDQ


Conserved Protein Domain Family
ASKHA_NBD_ChPPX-like
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cd24055: ASKHA_NBD_ChPPX-like 
nucleotide-binding domain (NBD) of Cytophaga hutchinsonii exopolyphosphatase (ChPPX) and similar proteins
The PPX/GppA family proteins play essential roles in bacterial survival and metabolism. Guanosine pentaphosphate (pppGpp) phosphohydrolase (GppA; EC 3.6.1.40) plays a key role in (p)ppGpp homeostasis. It specifically catalyzes the conversion of pppGpp to ppGpp (guanosine tetraphosphate). Sharing a similar domain structure, GppA is indistinguishable from exopolyphosphatase (PPX; EC 3.6.1.11), which mediates the metabolism of cellular inorganic polyphosphate. Especially, it is responsible for the maintenance of appropriate levels of cellular inorganic polyphosphate (PolyP). The family corresponds a group of proteins similar to uncharacterized Cytophaga hutchinsonii exopolyphosphatase (ChPPX).
Links
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Statistics
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PSSM-Id: 466905
Aligned: 31 rows
Threshold Bit Score: 332.605
Created: 23-Jan-2023
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
catalytic siteactive siteputative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:
  • Comment:The four catalytic residues are conserved among PPX/GppA homologs.
  • Comment:The PPX/GPPA enzymes use metal ions for catalysis.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                                                           
3MDQ_A         6 IGVIDXGTNTFHLLITDIvn--drPHTLVNEKSAVGLgkggitkGFITEEAXDRALDTLKKFRVILDEHav--vHVIATG 81  Cytophaga hutch...
TVR90264      11 VAAIDAGTNTFHLLISTAasp-lpDPDQIRLRKFVKLgee--spFHIGEMAFERGLNAMREFAQIAKSErv--eNIVAVG 85  Saprospirales b...
WP_013766245   3 LAIIDLGTNIFHLRIVKVqad-gsFLELFRRSQFIKLaad--giGTIGPEPFQRGLTCIQEYAQILVQHqa--dQTRAIG 77  Haliscomenobact...
TAE49208      17 WAVIDLGTNIVKLSLANQkg--kkLVYFRNENFPVFIgkdginkNIIQKDAEIRLFDALDQCQKIIKDEnithyQTFIVA 94  Cytophagales ba...
WP_130925435   4 RAIIDLGTNTFQLLIAQKansengMLVLAHEQRAVSLgkgamksDILQDDAMERAFETLKEFKQIANSYqcsdnQIVALG 83  Aquirufa nivali...
RLD22330       6 LAVIDLGTNTFHLLVVEAkg--nsWNELYRERIFVNLaed--giQMIGDTARERGLDALRHFSHIIREHav--tDTMAVG 79  Bacteroidetes b...
WP_052594437   3 IAIIDCGTNTFTLSLFEVdns-nqFRRSLKDRHYVELaee--giHQIGPKAFQRGVAAFQAFHDFLQQYpk--aKALAIG 77  Aureispira sp. ...
WP_081413657   9 LALMDLGTNTFHLLIFDAs-----GRDIHRRSHPVKMgeggisrGQIAPAAQERILAAFALFSQDLAQYrvpatSVQAVA 83  Eisenibacter el...
KXK17699       4 EAVIDLGTNSFNLLIGRSed--gkKEIMYRESRIVQLake--giTPIGDASLQRAMDALDVFQEKISNYka--eRVRVIG 77  
CCF99265       7 LAIIDLGTNTFHLLLVESskskigFEVLYRERHYVLLaeg--giDTISDSSMQRAKSAIDAFRNVLSNYkd--iELVIVG 82  uncultured Flav...

Feature 1                                        #                       #      #                
3MDQ_A        82 TSAVRSGsNKQVLIDRIKKEvNIDVEVIDGAREAELIFRGVQQAvp-xeDHISLAXDIGGGSVEFIIGNKneILWKQSFE 160 Cytophaga hutch...
TVR90264      86 TAMLRNAnNSNDFIRTVMEEtGIDIEVISGQTEAELIFKGALLSgn-lsGKTDLLMDIGGGSVEFILAEKyrANWRESFN 164 Saprospirales b...
WP_013766245  78 TAAMRTAsNGSAFIQAVKETtGLEITLIDGDQEAHYIHRGVEQAvq-fgADKKLIMDIGGGSVEFIIADLdeVYWAQSFP 156 Haliscomenobact...
TAE49208      95 TSALRNAeNGQEIALKIRQKyNFFIEIISGEKEATLIAEGVKQGfp-tiNEMILIMDIGGGSVEFVLTNGqkIFWKKSFE 173 Cytophagales ba...
WP_130925435  84 TSILRRAkNTPELVEKVQNQlGIRVEIISGIREAELIYQGIESSlpkpwNSTSLVMDIGGGSVEFILFRSnqVLGKISLE 163 Aquirufa nivali...
RLD22330      80 TAALRTAkNADQFVNDAQQElGISIHVIDGQKEAEYINAGVMRVvp-dsQDNFLIMDIGGGSVEFILSSNyqPVFSVSYP 158 Bacteroidetes b...
WP_052594437  78 TAALRRAaNRNDFLDAVEAVsGIRIQIIDGSKEAELIYRGVRTAap-lsATPSLIMDIGGGSVEFIIADQerVYWAKSYP 156 Aureispira sp. ...
WP_081413657  84 TSAFRAAdNATAVCEAIRQQsGIEIQIIDGQEEAALIAAGVQQAvp-mdERPALICDIGGGSIEFILCDAsqTYWQGSFE 162 Eisenibacter el...
KXK17699      78 TSALRSAsNSDDAISKIRSRyHWEVSIIDGEAEARYIFVGTMEAlq-isDETCLIMDIGGGSVEFILTKAgkMLWWTSVP 156 
CCF99265      83 TEALRVAtNGNLINIYIKEHlSSVPYTISGNREAELIYKGNKLIvs-adHTPYLIMDIGGGSTEFILVDDnhIILSKSYP 161 uncultured Flav...

Feature 1                                                                                        
3MDQ_A       161 IGgQRLIDRFhvhdpxrEDDRVXXHNYFDEVLVPLEKAIntwrpTQLIGCSGTFDTLAEXNIQhhrek---ialekQTSY 237 Cytophaga hutch...
TVR90264     165 IGvSSLKHHFhpndplvDEDIRKLRSYIDEQIESLFNQLqgrmgLRLVGLSGTFDVIEEHMRVkk----------gLQAN 234 Saprospirales b...
WP_013766245 157 VGmAVLYRNFhqsdpisTAEIADLRVFLSRQLTSLQAALnqfevTDLVGTRGTFDVLVAQFSTak---------qgPHCE 227 Haliscomenobact...
TAE49208     174 IGaARLKEKYhrsepisDLDLYRLMIFLELELATLREICfqycpKYLIGTAGTFETLAEIHLLnlgt-----pdinPHGL 248 Cytophagales ba...
WP_130925435 164 IGgLQLQSLFhvhgeydQQIEETLESFIQQALEPLDQLClhekpEVLIGAAGAFETLWDLEMAsslte----nnsaGSSH 239 Aquirufa nivali...
RLD22330     159 IGvAVLYDMFhhtepmnASALDQMDQFLSHTMEDLSRAIgqfgtLGLVGASGTFEVIDSAVQNni---------gkEDYS 229 Bacteroidetes b...
WP_052594437 157 IGvAVLFKNFqhsdpihIDHIQQLNKHLEKELSDLLEQLeahaiEHLIGASGSFDVLDSLNGAkd---------atASFG 227 Aureispira sp. ...
WP_081413657 163 IGaQRMLDKFmpgttllPEALAQLWAWLDAQLPDLYQACaeqapQRFIGAAGAFETLVLMHECrqrqaatfrfpenQTHF 242 Eisenibacter el...
KXK17699     157 IGvQYLYLHFgrnvptmPEEVAALERLLDLELAGLKKAIrqfkpERLIGASGAFDELLQMSAIpa----------gDKFT 226 
CCF99265     162 LGvTKIYNAFndtdpisIQAIFSIESHIENLLSDMTEVIkgynlNCLIGTSGSFEVLSEVLTGni---------pqQDLV 232 uncultured Flav...

Feature 1                                                                             
3MDQ_A       238 LLSlPDFNRLRKQLVASTRRERLAIAgxiELRADXVVVAICLIEHVLKLVstNAITVSTySLKEGVLYT 306 Cytophaga hutchinsonii ATC...
TVR90264     235 TIPlTEVKDFINEILPLSLEARINHPsipPSRADLISVALVLVDQILSRPeiSELNTSPySIKEGLLMH 303 Saprospirales bacterium
WP_013766245 228 ILPiDELPSFFAKVTQTSLAERSMMPeipADRIDMIVVGMLLIQFVLEMTgvPRILVSDfDVKEGVLAE 296 Haliscomenobacter hydrossis
TAE49208     249 VLSmEQFESLHQMLINRTYEQRLQLGglaEFRAELIVIAVCILRNVLLMTniDKICVSEyALKEGYLQK 317 Cytophagales bacterium
WP_130925435 240 PLSiSQFQINKALIESIPYSERVNLPgmkKFRASILPYANALISQVLQRYhiPKMWISTfSLKEGYWFY 308 Aquirufa nivalisilvae
RLD22330     230 RIEkEAFFNMYNRVVPMNFEERQSDPtipHTRTRYIVVALKLIEHVLTRFpiSDIGVSRyALKEGIVRE 298 Bacteroidetes bacterium
WP_052594437 228 YIQpNAFEAIYQQLVESSYEQRLVTKnlsSTRAKLIVMSVLLIRFIHQKIntPNLVVSDhAMREGLVYE 296 Aureispira sp. CCB-QB1
WP_081413657 243 VVDaAGFEAVYEDLIFSEESVRQALPglaGFRAQMMVPATALMQWVRLRFglPVVEVSTyTLQQGLKQS 311 Eisenibacter elegans
KXK17699     227 RLDtPIFYENFEKLQKQVTERRNVSTmrtEERPEIVMTGFLLIRYVLQLIkvPEIIATPfALREGVFFM 295 
CCF99265     233 NISlADFEKLSMKVISSSIDERRDVKgipENRVKFIQVAFIMMRKIIYMYapDQIGVSPfAIKEGLISE 301 uncultured Flavobacteriia ...

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