5N8L,3ADL,2CPN


Conserved Protein Domain Family
DSRM_TARBP2_rpt2
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cd10844: DSRM_TARBP2_rpt2 
second double-stranded RNA binding motif of the RISC-loading complex subunit TARBP2 and similar proteins
TARBP2 (also known as TAR RNA-binding protein 2, or trans-activation-responsive RNA-binding protein (TRBP)) participates in the formation of the RNA-induced silencing complex (RISC). It is part of the RISC-loading complex (RLC), together with dicer1 and eif2c2/ago2, and is required to process precursor miRNAs. TARBP2 contains three double-stranded RNA binding motifs (DSRMs). This model describes the second motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380681
Aligned: 6 rows
Threshold Bit Score: 133.693
Created: 1-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
RNA binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:5N8L; Homo sapiens TARBP2 in complex with siRNA, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        # ##  ##  ##    ##         # ### #               ####  ##          
5N8L_A       147 NPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRV 213 human
Q7SXR1       139 NPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFVEIGSGTSKKLAKRNAAAKMLSRI 205 zebrafish
3ADL_A        16 HEVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRV 82  human
2CPN_A        17 NPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRV 83  human
Q6GPZ1       150 NPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFLEIGSGTSKKLAKRNAAAKMLLQI 216 African clawed frog
XP_005991502  70 DINCTDIELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLSRI 136 coelacanth

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