3HNA,4I51,2IGQ,3FPD


Conserved Protein Domain Family
SET_EHMT1
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cd10535: SET_EHMT1 
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.
Links
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Statistics
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PSSM-Id: 380933
Aligned: 9 rows
Threshold Bit Score: 494.837
Created: 20-May-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3HNA; Homo sapiens EHMT1 binds SAH and mono-methylated H3k9 peptide, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
3HNA_A         57 SNYKYVsQNCVTSpmnidrnitHLQYCVCidDCsssNCmCGQLSmrCWYDKDGRLLPefnmaepPLIFECNHACSCwrNC 136  human
4I51_A         56 SNYKYVsQNCVTSpmnidrnitHLQYCVCidDCsssNCmCGQLSmrCWYDKDGRLLPefnmaepPLIFECNHACSCwrNC 135  human
2IGQ_A         55 SNYKYVsQNCVTSpmnidrnitHLQYCVCidDCsssNCmCGQLSmrCWYDKDGRLLPefnmaepPLIFECNHACSCwrNC 134  human
3FPD_A         31 SNYKYVsQNCVTSpmnidrnitHLQYCVCidDCsssNCmCGQLSmrCWYDKDGRLLPefnmaepPLIFECNHACSCwrNC 110  human
NP_001012550  986 SNYKYVsQNCVTSpmdidrnitHLQYCVCidDCsssNCmCGQLSmrCWYDKDGRLLPefnmaepPLIFECNHACSCwrTC 1065 chicken
NP_001096168  970 VNYKYVsQNCVTSplnidrnitHLQYCVCidDCsssNCmCGQLSmrCWYDKNGRLLPefnmlepPLIFECNHACSCwrNC 1049 western clawe...
Q9H9B1       1036 SNYKYVsQNCVTSpmnidrnitHLQYCVCidDCsssNCmCGQLSmrCWYDKDGRLLPefnmaepPLIFECNHACSCwrNC 1115 human
XP_014342081 1005 SDYKYVsQNCVTSplnidrnitHLQYCICtdNCsssNCmCGQLSirCWYNKEGRLLPefnmlepPLIFECNHACSCwrTC 1084 coelacanth
XP_007894428 1119 NDYKYVsQNCVTSpmnidrnitHLQYCFCedDCsssNCmCGQLSirCWYDRNGRLLPefnmvepPLIFECNHACGCwrTC 1198 elephant shark

Feature 1                             ###                #      #  ## #  ######  #      #         
3HNA_A        137 RNRvvQNGLRARLQLYRTrdMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDgEVYCIDARFYGNV 216  human
4I51_A        136 RNRvvQNGLRARLQLYRTrdMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDgEVYCIDARFYGNV 215  human
2IGQ_A        135 RNRvvQNGLRARLQLYRTrdMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDgEVYCIDARFYGNV 214  human
3FPD_A        111 RNRvvQNGLRARLQLYRTrdMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDgEVYCIDARFYGNV 190  human
NP_001012550 1066 RNRvvQNGLRTRLQLYRTqkMGWGVRTMQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDgEVYCIDARFYGNI 1145 chicken
NP_001096168 1050 RNRvvQNGLKIRLQLFRTksKGWGVRSLQDIPQGTFVCEYVGELISDAEADVREDDTYLFDLDNKDrEVYCIDARFYGNI 1129 western clawe...
Q9H9B1       1116 RNRvvQNGLRARLQLYRTrdMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDgEVYCIDARFYGNV 1195 human
XP_014342081 1085 QNRvvQNGLRVRLQLYRTekMDWGVRALQDIPQGTFVCEYVGELISDAEADVREDDSYLFDLDNKDgEVYCIDARFYGNI 1164 coelacanth
XP_007894428 1199 KNRvvQNGVRVRLQIYRTnkMGWGVRSLQDIPKGNFICEYVGELITDAEADVREEDSYLFDLDNKEgEVYCIDARYYGNI 1278 elephant shark

Feature 1          #####       # #            #               # #  ##  ##   #####        
3HNA_A        217 SRFINHHCEPNLVPVRVFMaHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 287  human
4I51_A        216 SRFINHHCEPNLVPVRVFMaHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS 286  human
2IGQ_A        215 SRFINHHCEPNLVPVRVFMaHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 285  human
3FPD_A        191 SRFINHHCEPNLVPVRVFMaHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 261  human
NP_001012550 1146 SRFINHLCEPNLIPVRVFMsHQDLRFPRIAFFSTRHIEAGEEIGFDYGDRFWDIKGKFFSCQCGSPKCKHS 1216 chicken
NP_001096168 1130 SRFINHLCEPNLLPVRVFMsHQDLRFPRIGFFSSRHIGAGEEIGFDYGDRFWDVKGKLFSCQCGSPKCKHP 1200 western clawed frog
Q9H9B1       1196 SRFINHHCEPNLVPVRVFMaHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 1266 human
XP_014342081 1165 SRFINHLCEPNLIPVRVFMsHQDLRFPRIAFFSTRHINAGEELGFDYGDRFWDIKSKHFTCQCGSVKCKHS 1235 coelacanth
XP_007894428 1279 SRFVNHLCEPNLIPVRVFMsHQDLRFPRIAFFSSRDIKTGEELGFDYGDRFWDIKSKSFTCQCGSEKCKHS 1349 elephant shark

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