1MQ4,1OL5,2C6D,1OL6,3E5A


Conserved Protein Domain Family
STKc_Aurora-A

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cd14116: STKc_Aurora-A 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 271018
Aligned: 8 rows
Threshold Bit Score: 556.878
Created: 12-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:1OL6: Human Aurora-A kinase binds ATP; contacts at 4A.
  • Structure:1MQ4: Human Aurora-A kinase binds Mg2-ADP; contacts at 4A.
  • Structure:2C6D: Human Aurora-A kinase binds ANP; contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    #####   #            # #                               #            
1MQ4_A         8 QWALEDFEIGRpLGKGKFGNVYLAREKQSKFILALKVLFKAQLEkagvEHQLRREVEIQSHLRHPNILRLYGYFHDatRV 87  human
1OL5_A         6 QWALEDFEIGRpLGKGKFGNVYLAREKQSKFILALKVLFKAQLEkagvEHQLRREVEIQSHLRHPNILRLYGYFHDatRV 85  human
2C6D_A         4 QWALEDFEIGRpLGKGKFGNVYLAREKQSKFILALKVLFKAQLEkagvEHQLRREVEIQSHLRHPNILRLYGYFHDatRV 83  human
1OL6_A         6 QWALEDFEIGRpLGKGKFGNVYLAREKQSKFILALKVLFKAQLEkagvEHQLRREVEIQSHLRHPNILRLYGYFHDatRV 85  human
3E5A_A         4 QWALEDFEIGRpLGKGKFGNVYLAREKQSKFILALKVLFKAQLEkagvEHQLRREVEIQSHLRHPNILRLYGYFHDatRV 83  human
XP_425725    141 QWSLDDFEIGRpLGKGKFGNVYLAREKQSKFILALKVLFKAQLEdagvEHQLRREVEIQSHLRHPNILRLYGYFHDvtRV 220 chicken
Q91819       134 QWCLEDFEIGRpLGKGKFGNVYLARERESKFILALKVLFKSQLEkagvEHQLRREVEIQSHLRHPNILRLYGYFHDacRV 213 African clawed ...
NP_001003640 132 AWTLENFDIGRaLGKGKFGSVYLAREQQTKFILALKVLFKKQLEkagvEHQLRREVEIQSHLRHPNILRLYGYFHDaaRV 211 zebrafish
Feature 1            # #   #                                          ## #          #            
1MQ4_A        88 YLILEYAPlGTVYRELQKLskFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGsaGELKIADFGWSVHAPSSRR 167 human
1OL5_A        86 YLILEYAPlGTVYRELQKLskFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGsaGELKIADFGWSVHAPSSRR 165 human
2C6D_A        84 YLILEYAPlGTVYRELQKLskFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGsaGELKIADFGWSVHAPSSRR 163 human
1OL6_A        86 YLILEYAPlGTVYRELQKLskFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGsaGELKIANFGWSVHAPSSRR 165 human
3E5A_A        84 YLILEYAPlGTVYRELQKLskFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGsaGELKIADFGWSVHAPSSRR 163 human
XP_425725    221 YLILEYAPrGEVFKELQKLtkFDEQRTATYITELADALSYCHSKSVIHRDIKPENLLLGsnGELKIADFGWSVHAPSSRR 300 chicken
Q91819       214 YLILDYAPgGELFRELQKCtrFDDQRSALYIKQLAEALLYCHSKKVIHRDIKPENLLLGsnGELKIADFGWSVHAPSSRR 293 African clawed ...
NP_001003640 212 YLILEFAPkGELYGELQRCgtFDDQRSATYIMELADALRYCHSKAVIHRDIKPENLLLGanGELKIADFGWSVHTPSSRR 291 zebrafish
Feature 1                                                                                        
1MQ4_A       168 TTLCGTLDYLPPEMIEgrmhDEKVDLWSLGVLCYEFLVGKPPFEAntYQETYKRISRVEFTFPDFVtEGARDLISRLLKh 247 human
1OL5_A       166 XXLCGTLDYLPPEMIEgrmhDEKVDLWSLGVLCYEFLVGKPPFEAntYQETYKRISRVEFTFPDFVtEGARDLISRLLKh 245 human
2C6D_A       164 TDLCGTLDYLPPEMIEgrmhDEKVDLWSLGVLCYEFLVGKPPFEAntYQETYKRISRVEFTFPDFVtEGARDLISRLLKh 243 human
1OL6_A       166 TTLCGTLDYLPPEMIEgrmhDEKVDLWSLGVLCYEFLVGKPPFEAntYQETYKRISRVEFTFPDFVtEGARDLISRLLKh 245 human
3E5A_A       164 TXLCGTLDYLPPEMIEgrmhDEKVDLWSLGVLCYEFLVGKPPFEAntYQETYKRISRVEFTFPDFVtEGARDLISRLLKh 243 human
XP_425725    301 STLCGTLDYLPPEMIEgrthDEKVDIWSLGVLCYEFLVGKPPFEAqtYQETYRAISRVEFKYPLFVtEGARDLISKLLKh 380 chicken
Q91819       294 TTLCGTLDYLPPEMIEgrmhDEKVDLWSLGVLCYEFLVGKPPFETdtHQETYRRISKVEFQYPPYVsEEAKDLVSKLLKh 373 African clawed ...
NP_001003640 292 STLCGTLDYLPPEMIEgkthDEKVDLWSLGVLCYEFLVGRPPFETksHEETYRKISRVEFTYPAHVsNGSRDLINRLLKh 371 zebrafish
Feature 1                          
1MQ4_A       248 nPSQRPMLREVLEHPWIT 265 human
1OL5_A       246 nPSQRPMLREVLEHPWIT 263 human
2C6D_A       244 nPSQRPMLREVLEHPWIT 261 human
1OL6_A       246 nPSQRPMLREVLEHPWIT 263 human
3E5A_A       244 nPSQRPMLREVLEHPWIT 261 human
XP_425725    381 nPFHRLPLKDVLVHPWIT 398 chicken
Q91819       374 nPNHRLPLKGVLEHPWIV 391 African clawed frog
NP_001003640 372 nPMHRLPIQGVMEHPWVV 389 zebrafish

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