1J2F


Conserved Protein Domain Family
IRF-3
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pfam10401: IRF-3 
Interferon-regulatory factor 3
This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.
Links
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Statistics
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PSSM-Id: 463076
Aligned: 26 rows
Threshold Bit Score: 171.286
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1J2F_A        32 EWEFEVTAFYRGRQVFQQTISCPEGLRLVG-SEVGDRTL--------------PGWPVTLPDPGMsLTDRGvMSYVRHVL 96  human
NP_001071743 334 AHEMEVYIRYRRSNVLACHVTEPTGCRISYgNSSLQLIAsathelpnsvfgpeTLQQIELLDCEPyASSETqIQLTKHIL 413
NP_001122338 311 MLMYKVTLKYNGMVVKSEKLSLAKGVRFMF-GSPLLQKNvveafrs-gerelvDLQTWEFPEQQM-LSSN--SANIDSIL 385
Q5XIB0       196 QWEFEVTAFYRGRQVFQQTLFCPGGLRLVG-STSDNGTL--------------PWQPVTLPDPEEfLTDRLvREYVRQVL 260 Norway rat
Q4JF28       197 DWEFEVTAFYRGCQVFQQTVFCPGGLRLVG-SEAGDRML--------------PGQPIRLPDPATsLTDKSvTDYVQRVL 261 cattle
Q90643       283 PPLLDITIYYRGKMVYQEQVDDSR-CVLAY-QPLDPAVA--------------EQRLVLFPSPAS-LPDPRqRRYTEDLL 345 chicken
NP_001300708 169 NLDLEISISYRRTEVLKTRLCSSL-IHFFY-QCDPSEL---------------RGEQIRFPTTDC-LIDVKqIQYTKRIL 230
CAG02387     253 ICDLEISIHYRKKEMLKTTVRAPR-LQLHY-HSEAPELE--------------ANHHICFPPTDG-LLDHKqVEYTNRIL 315
CAF98086     257 DIRLHVSVFYRDSLVREVTISSPEGCHLTP-CSPDEKPypq----------agSPEVVPLPVDSL-SPPRRtDDGPPSPP 324
EDM14250     209 DYSLLLTFIYGGRVVHEIQVHSLD-CRLVA-EPSDPESS--------------MVQQVVFPRPDP-------LEPTQSLL 265

1J2F_A        97 SCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNsghgPDgEVPKDKEGGVFDLGPFIVDLITFTE-GSGRSPRY-A 174 human
NP_001071743 414 NNLRRGLILSYSGGCFYAKRLCQSRVFVYGPETSGSA----PE-KLERNASVKLFDYRKFCENLQQVSQvGKFRSVEA-E 487
NP_001122338 386 KSTDLGIVLQAQQNGLTAKRLCQSQIFYFDQSNQGGH----SV-KLERKVAIEVLSHAKWVRSLLEQQRgSNTISPNEgS 460
Q5XIB0       261 KGLGKGLVLWRAGQCLWAQRLGHSHSFWALGEELLPDsgrgPDgEVPKDKNGVVFDLRPFVADLIAFME-GSRHSPRY-T 338 Norway rat
Q4JF28       262 SCLGGGLALWRAGQWLCAQRLGHCHVYWAIGEELLPScghkPDgEVPKDREGGVFNLGPFITDLITFIE-GSRRSPLY-T 339 cattle
Q90643       346 EV--AGLRLEQRAGQLLATRLKKCKVFWALSQQLEGGe--pPLnLLHRDQETTIFDFRVFCTELRDFRDsRRERSPDF-T 420 chicken
NP_001300708 231 DSIQRGLQLEVNQYGIYGFRQDKCKVFVSTSDPCEIQkp-ePR-KLQQNSKEQLLSFDKYIRDLLDFKE-NRGGSPDY-T 306
CAG02387     316 NSIQKGLLLEVRDTGIYATRQDRCHVFASTSDPSTAHl--ePS-KLPQNNMVELLSFAKYVHELKLFRE-NNGGSPEY-T 390
CAF98086     325 STLEKGVFLWMGPDGLYARRLCQSRVYWQRGSSQYADk---PN-NLERGVSYKLLHTQDCLAEIQSYGL-HGRPPPRF-Q 398
EDM14250     266 NQLERGILVASNSRGLFVQRLCPIPISWNAPEAPPGPg---PH-LLPSNKCVELFSTTYFCRDLAQYFQ-GQGPLPKY-Q 339

1J2F_A       175 LWFCVGESWpqDQPWTKRLVMVKVVPTCLRALVEMAR 211 human
NP_001071743 488 IRISFAQTWsvQNPIEKNLVNLYMIPRAAKYLLTKVR 524
NP_001122338 461 VKLVIGTKPs--SIRSVGLVSLTIQSACADILIKQFS 495
Q5XIB0       339 LWFCVGESWpqDQPWVKRLVMVKVVPTCLKELLEMAR 375 Norway rat
Q4JF28       340 LWFCVGQSWpqDQPWIKRLVMVKVVPMCLRVLVDIAR 376 cattle
Q90643       421 IFLCFGQCFssTKPKESKLILVKLVPQFCEYWYEQVQ 457 chicken
NP_001300708 307 IYLCFGEKLhdGKPLEKKLITVKVVPLICRELHERAQ 343
CAG02387     391 INMCFGEKFpdGKALEKKLVTVKVVPLVCRHFYEMAH 427
CAF98086     399 ILLSFGDECl-dPQRLRRTLTVQVEPLFSRQLLYYAQ 434
EDM14250     340 ATLHFWDRSpsSSHTQENLITVRMEQAFARNLLEKIP 376
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