3O7H


Conserved Protein Domain Family
UraD_2
?
TIGR03180: UraD_2 
Click on image for an interactive view with Cn3D
OHCU decarboxylase
Previously thought to only proceed spontaneously, the decarboxylation of 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) has been recently been shown to be catalyzed by this enzyme in Mus musculus. Homologs of this enzyme are found adjacent to and fused with uricase in a number of prokaryotes and are represented by this model. This model is a separate (but related) clade from that represented by TIGR3164. This model places a second homolog in streptomyces species which (are not in the vicinity of other urate catabolism associated genes) below the trusted cutoff.
Links
?
Statistics
?
PSSM-Id: 188295
Aligned: 8 rows
Threshold Bit Score: 169.945
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3O7H_A        30 FNSLSKDEAAGLLAPCVALPAWGETLVSLRPFASRHALLQTAREAMANWGEDELNAALSAHPRIGEKPTGSQAHAAL--- 106 Klebsiella pneu...
WP_004923280   6 FNDAPSDDANAVLSACVHIPSWINTLCQQRPYPSREVLFDSAKQQTQNWSWNDIHAALATHPRIGEKKAKQQLTEREekf 85  Acinetobacter
WP_011045588   6 LNQLPAAEASHTFMQCCSASAWVKKMVTARPFSSELAIKKAADDAWQGLTEQDYFEAFEGHPKIGDVSSLRAKYANT--- 82  Colwellia psych...
WP_011776141  18 FNSVERDQAIKTLTPCLDISRWVEAIVDARPYASVDELLGQAQRAAEPFTAAEVESAMAHHPRIGERPKAQTTEAAM--- 94  Arthrobacter
AIE03267       7 FNGLSKDEAVGLLAPCVAIPAWGETLVNLRPFASRHALLQTAREAMDYWGEDELNAALSAHPRIGEKPTGGQAHAAL--- 83  Klebsiella pneu...
WP_003972718  12 FNTLEETAALAELHEACAATAWARHLLAARPFATAEDLYAASDAAMAELSAEDLAEAMAGHPPIGRPKPGDA----T--- 84  Streptomyces
WP_011211778  12 fdalpaaaataallEVCASPEWARRVVAGRPYGTAERLYAAAERVLADLPEREIDRALAGHPRIGEQPGGAAA------- 84  Nocardia farcinica
WP_011435293 346 FDALSPDAAREELLACCESEDWAAAVAARRPFGTLAALLPAAEQEWWNLPASAWLEAFTAHPRIGERPAHTPAPPTT--- 422 Frankia

3O7H_A       107 S---R----------QEQSSVDSeNERLAQALREGNARYEARFGRVFLIRAKGRSGEEILQALTRRLQHTADEEVAEALA 173 Klebsiella pneu...
WP_004923280  86 S---D----------SEQSGVKQ-DQYTQQALLEGNMAYEQKFGFIFLIKAAGLSSDDMLNALQQRLNHDLETEKNIVHQ 151 Acinetobacter
WP_011045588  83 KelaG----------NEQGLVKEaNDDVLEVLSQGNSDYEKKFGFIFIVCATGKSAKQMSDLLQARLPNNKTQELVNAAE 152 Colwellia psych...
WP_011776141  95 S---R----------SEQAGVDPgDNHTTAALAEGNRAYEEKFGRVFLIRAAGRSAEEILNTLQERITHTPEEEDTIVAG 161 Arthrobacter
AIE03267      84 S---R----------QEQSAVDSeNERLAQALQEGNARYEARFGRVFLIRAKGRSGEAILQALTRRLQHTADEEVTEALA 150 Klebsiella pneu...
WP_003972718  85 S---S----------REQAGMAGaAEELKAEMLELNLAYQDKFGHVFLICATGRTGEQMRDAALERIGNSPEQEREIVRT 151 Streptomyces
WP_011211778  85 ----S----------HEQAGVAGaDAATRAALAAGNRAYERRFGRIYLVSAAGRSADELLAILEARLRNDPEVETRVLRE 150 Nocardia farcinica
WP_011435293 423 A---RatvvsldaprREQAAMDQaTAEVRAAFEQGNAAYEERFGYIFLVRAAGRDAEEMLALLRARLDNDPADELRIAAG 499 Frankia

3O7H_A       174 QLREITMLRLEGAI 187 Klebsiella pneumoniae subsp. pneumoniae MGH 78578
WP_004923280 152 QLAAIALLRLSQGI 165 Acinetobacter
WP_011045588 153 EQRKIFQLRIDKAL 166 Colwellia psychrerythraea
WP_011776141 162 QLREIALLRLSGLI 175 Arthrobacter
AIE03267     151 QLREITMLRLEGVI 164 Klebsiella pneumoniae subsp. pneumoniae KP5-1
WP_003972718 152 ELGKINRIRLTRLV 165 Streptomyces
WP_011211778 151 ELAKINRLRLGRLP 164 Nocardia farcinica
WP_011435293 500 QQAEITALRIRRLI 513 Frankia
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap