3JVE,3PD7


Conserved Protein Domain Family
BRCT_TopBP1_rpt6
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cd17727: BRCT_TopBP1_rpt6 
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.
Links
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Statistics
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PSSM-Id: 349359
Aligned: 29 rows
Threshold Bit Score: 92.2748
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [CS]Click to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
3JVE_A         18 LHKVVVCVSKKlskkQSELNGIAASLGADYRWSFDETv-THFIYQGRPNdt--------------------------nrE 70   human
XP_002109490  733 LKGVTISASKKlsssHRQFEREASQLGADWRWTFEDCc-THFIYQVADVtltrvqidndkcitplpnlfekgkatennrE 811  Trichoplax ad...
XP_004210149  918 LSGVVLVVSKAlaqkQMELHKKAQHLGAECRFMYDSEc-THFVHQGRVNds--------------------------nkD 970  Hydra vulgaris
GAA28015      884 LRGVVICVAKHlssrQVELNGITRQLGGDFKWIYDPLvcTHIIAEYETVgqappsdhq------------sgeqqdpypD 951  Clonorchis si...
ORY39842      789 LKGVRLCLSQKsiphRHDAIRLCKNLGAEFLNTYSDSc-THYVQDKSGGgg---------------------------yE 840  Rhizoclosmati...
OUC44969       43 LSGVVIVVSSDllhlQMELHQLVIQLGGFYCWHFDPSc-THFICQGTNVek--------------------------trE 95   Trichinella n...
ORX68672      625 LDGVVIALTTRlyhrRNELTGIATELGCRMLPRFDPTttTHLVHQSTREnet-------------------------lrD 679  Linderina pen...
ORX43425      751 LKGVVISISQRlshrKNELWELATKMGAECIVKYDDTc-THYIHSGVRAkes-------------------------fkD 804  Piromyces sp....
ORZ41614      151 LDGVIVYVTDSve-qAEDMHTLAQSLGARYLTSFSPRc-THVVHMSKHPppaksd-------------------ikeasE 209  Catenaria ang...
KFH69636      725 LDGCRVCVPTRirdiHKELCELVVELGGELLTTYNNSa-THLIQKGKADkta-------------------------trE 778  Mortierella v...

Feature 1                            #   #  
3JVE_A         71 YKSVKER----GVHIVSEHWLLDCAQ 92   human
XP_002109490  812 LKAAKKA----KAILVSPSWLKACLT 833  Trichoplax adhaerens
XP_004210149  971 YMEAKRN----KKYLVSPFWLEACLS 992  Hydra vulgaris
GAA28015      952 VTAARSA----GKFIVNPRWLTSCEA 973  Clonorchis sinensis
ORY39842      841 WKRVRDDeakgRVKVVSFRWLEVCGE 866  Rhizoclosmatium globosum
OUC44969       96 GYKAIEA----GCALVHPRWLYQCKI 117  Trichinella nativa
ORX68672      680 YKTATQH----GINVVSPWWLYACRD 701  Linderina pennispora
ORX43425      805 FKLAYAK----KKFIVSPIWLQKCYE 826  Piromyces sp. KS-2015
ORZ41614      210 VEVARGL----GKFVVSPWWLTMCSR 231  Catenaria anguillulae PL171
KFH69636      779 IRAAQRE----RIKVVCPTWLYQCKA 800  Mortierella verticillata NRRL 6337

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