1O24,4FZB,3GWC,3N3Y


Conserved Protein Domain Family
thyX
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TIGR02170: thyX 
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thymidylate synthase, flavin-dependent
Two forms of microbial thymidylate synthase are known: ThyA (2.1.1.45) and ThyX (2.1.1.148). This model describes ThyX, a homotetrameric flavoprotein. Both enzymes convert dUMP to dTMP. Under oxygen-limiting conditions, thyX can complement a thyA mutation. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
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Statistics
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PSSM-Id: 274010
Aligned: 19 rows
Threshold Bit Score: 219.53
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1O24_A    22 FVELVDVm--------------gNDLSAVRAARVSFDMg---lKD---EERDRH-------LIEYLMK--HGHETPFEHI 72  Thermotoga maritima
Q9WYT0    10 FVELVDVm--------------gNDLSAVRAARVSFDM-----GLk-dEERDRH-------LIEYLMK--HGHETPFEHI 60  Thermotoga maritima...
Q9ZDM6    28 FIRVIDYm--------------gDDSSIVQAARVSYGK-----GTk-qLNQDKG-------LINYLLR--HYHTTPFEMC 78  Rickettsia prowazek...
O50965    12 FLKLIDFm--------------gDDRRIVKAARISYRE-----ESv--KRKDAE-------LIDYLIR--NGHTSPLEQV 61  Borrelia burgdorfer...
BAC90262  27 FIQLVDYmpsdypfgqvvegataGDIAIVAAARVSYGT-----VTk-gTDADRK-------LIEFLLR--HGHTSPLEMV 91  Gloeobacter violace...
O86840    18 TVELVKSa--------------aTDSDVLFAARVSTAGeqsldELkkdPERSKG-------LINYLMR--DRHGSPFEHN 74  Streptomyces coelic...
O41156     2 SAKLISVtkpvv------egvntAEELIAYAARVSNPE------NqinNKTASG-------LLKYCIR--HKHWSIFETA 60  Paramecium bursaria...
CAE06794   5 RVDLIAAtp-------------nPQLCVYAAMHQDYSEgf--vAAdreNWPDEQrag--eiCVKRLLAgeRGHYGPMEHA 67  Synechococcus sp. W...
AAL54978   2 KVELKTEyst-----------qnPDDVPVMAARGDYMSes--lVGkniEDALAGtpktheaLMGELLR--RGHFGPFEHI 66  Halorubrum phage HF2
4FZB_A     7 SAKLISVtkpvv------egvntAEELIAYAARVSNPE------NqinNKTASG-------LLKYCIR--HKHWSIFETA 65  Paramecium bursaria...

1O24_A    73 VFTFHVK-APIFVARQWFRHRIA-SYNELSGRYSKLS-YEfyIPSPERLEGYKTTIP-----------PERVTEKISEIV 138 Thermotoga maritima
Q9WYT0    61 VFTFHVK-APIFVARQWFRHRIA-SYNELSGRYSKLS-YEfyIPSPERLEGYKTTIP-----------PERVTEKISEIV 126 Thermotoga maritima...
Q9ZDM6    79 DIKFHIK-LPIFIARQWIRHRTA-SVNEYSARYSILG-NEfyLPDPANIASQSVVNKqcra---gdsvPKKVSEKVLAIL 152 Rickettsia prowazek...
O50965    62 VFTFHVK-APIFVARQWMRHRTA-RINEVSGCYSLAR-EEfyVPLEEDLKCQTSSNss--------ekEFKSLEKLSDKI 130 Borrelia burgdorfer...
BAC90262  92 EFKFIVK-APVVMWWQHVRHRIQ-EMNFQSGRYTPYPeNEfyLP--EKLRAQDKVNKqgsvl--vdflSSDEERALLEEL 165 Gloeobacter violace...
O86840    75 SMTFFVS-APIFVFREFMRHRVGwSYNEESGRYRELQ-PVfyAPDASRKLVQQGRPGkyvf----vegTPEQHELVGSAM 148 Streptomyces coelic...
O41156    61 FMTLELK-TSRGIAAQVLRHRSF-HFQEFSQRYASVMeTP---PP-HQARFQDHKNRqnsl----dtvPEDDQTWWATEQ 130 Paramecium bursaria...
CAE06794  68 QIVLNVGwFPHSVMQQARTHRVGvSFDVQSMRYTGERiCR--AANGELDLEEVFYLRpvgdysdrqgkKYAYTESQRALD 145 Synechococcus sp. W...
AAL54978  67 QAFFAVEgLSRSAMAQVTRHRHM-SFDVQSQRYCDFSdKNivIPPGD--KKNPAAEDvvlgq-ydgpaEDFTGAD---AL 139 Halorubrum phage HF2
4FZB_A    66 FMTLELK-TSRGIAAQVLRHRSF-HFQEFSQRYASVM--E--TPPPHQARFQDHKNRqnsl----dtvPEDDQTWWATEQ 135 Paramecium bursaria...

1O24_A   139 DKay----rTYLELIES------------GVPREVARIVLP-LNLYTRFFWTVNARSLMNFLNLRADSH--------AQW 193 Thermotoga maritima
Q9WYT0   127 DKay----rTYLELIES------------GVPREVARIVLP-LNLYTRFFWTVNARSLMNFLNLRADSH--------AQW 181 Thermotoga maritima...
Q9ZDM6   153 EEdarrcyrHYKELMNAdedgnildenvsGIARELARINLT-LNYYTEWYWKINLHNLLHFLRLRTDPK--------AQY 223 Rickettsia prowazek...
O50965   131 KHhqkhsyeLYQDMINA------------NIPKELSRIVLP-LSLYTEWYWQIDLNNLFHFIKLRLALDspkeikenSPK 197 Borrelia burgdorfer...
BAC90262 166 RAhyeagfsLYKKMLAK------------GVAKEMARLALPgWALYHTAYVKMNAHALMHYLAKRTEPD--------AQY 225 Gloeobacter violace...
O86840   149 EDsyrqayaTYQQMLAA------------GVAREVARAVLP-VGLYSSMYATCNARSLMHFLGLRTQHElakv-psfPQR 214 Streptomyces coelic...
O41156   131 EKlyaqsmeLYNKALEK------------GIAKECARFILP-LSTPTTIYMSGTIRDWIHYIELRTSNG--------TQR 189 Paramecium bursaria...
CAE06794 146 LDhcrasaeRYRDLLSA------------GFAEEHARGILP-FDYRQHFVVSFSLRAFLHFMDLRAKLD--------AQL 204 Synechococcus sp. W...
AAL54978 140 EGhfvnsveLYEKLIEQ------------GMAKEDARFVLP-IGVEVDMTFSANARTLMHFFDLRKNMK--------AQW 198 Halorubrum phage HF2
4FZB_A   136 EKlyaqsmeLYNKALEK------------GIAKECARFILP-LSTPTTIYMSGTIRDWIHYIELRTSNG--------TQR 194 Paramecium bursaria...

1O24_A   194 EIQQYALAIARIFKEKCPWTFEAF 217 Thermotoga maritima
Q9WYT0   182 EIQQYALAIARIFKEKCPWTFEAF 205 Thermotoga maritima MSB8
Q9ZDM6   224 EIRVYAEKILDIVKAWVPFTYEAF 247 Rickettsia prowazekii str. Madrid E
O50965   198 EMREYAKALISIVREIVPIAFNSF 221 Borrelia burgdorferi B31
BAC90262 226 EIRVYAQAMERIFAEKLPWVHDTW 249 Gloeobacter violaceus PCC 7421
O86840   215 EIEMAGEKMEAEWARLMPLTHAAF 238 Streptomyces coelicolor A3(2)
O41156   190 EHIDLANACKEIFIKEFPSIAKAL 213 Paramecium bursaria Chlorella virus 1
CAE06794 205 EIRQLCDLMWPHMVSWAPEFAGWY 228 Synechococcus sp. WH 8102
AAL54978 199 EAREFATKVLEECKEWSPLVFNAY 222 Halorubrum phage HF2
4FZB_A   195 EHIDLANACKEIFIKEFPSIAKAL 218 Paramecium bursaria Chlorella virus 1
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