6MAC,3KFD,2L5S,2PJY


Conserved Protein Domain Family
TFP_LU_ECD_ALK5

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cd23537: TFP_LU_ECD_ALK5 
extracellular domain (ECD) found in activin receptor-like kinase 5 (ALK-5) and similar proteins
ALK-5 (EC 2.7.11.30, also called TGF-beta receptor type-1 (TGFR-1), or activin A receptor type II-like protein kinase of 53kD, or serine/threonine-protein kinase receptor R4 (SKR4), or TGF-beta type I receptor, or transforming growth factor-beta receptor type I (TGFBR1), or TGF-beta receptor type I (TbetaR-I)) is the transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2, and TGFB3. It transduces the TGFB1, TGFB2, and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. This model corresponds to the extracellular domain (ECD) of ALK-5, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Statistics
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PSSM-Id: 467067
Aligned: 14 rows
Threshold Bit Score: 107.111
Created: 25-Jul-2016
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
trimertrimer
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:2PJY; Homo sapiens TGFBR1 in complex with TGFBR2 and TGFB3, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #                         ####### #            #####  #  
6MAC_K         2 LQCFCHLCTkdNfTCvTDGLCFVSVtet-tdKVIHNSMCIAEiDLIPRDRPFvCAPSSKtgsvtTTYCCNQDHCNK 76  human
2L5S_A         6 LQCFCHLCTkdNfTCvTDGLCFVSVtet-tdKVIHNSMCIAEiDLIPRDRPFvCAPSSKtgsvtTTYCCNQDHCNK 80  human
2PJY_C         2 LQCFCHLCTkdNfTCvTDGLCFVSVtet-tdKVIHNSSCIAEiDLIPRDRPFvCAPSSKtgsvtTTYCCNQDHCNK 76  human
XP_014351914  27 LQCHCHHCTqnNlTCeTDGLCLASVtrt-eeKVVYNSMCIAReELIPKDRPFiCAPSSKdgismVADCCDTDFCNK 101 coelacanth
NP_989577     28 LQCYCHLCTkdNfTCvTDGLCFTSVtrt-adRVIRNSMCIAEiDLIPRDRPFiCAPSFRdgvttLPHCCDRDHCNK 102 chicken
NP_001108531  34 LQCYCHRCP--NhTCtTDGLCYVSItra-gsLTTQQSWCIGKgELVPPDRPFvCAPSTKddsgiYPLCCDTDWCNK 106 zebrafish
NP_001015961  28 LICHCEQCA--NrTCmTDGLCLVNVliq-dgKVTHNSLCIADsERVPRDRPFmCFSTSTngiyhNVECCQTDFCNK 100 tropical clawed frog
XP_023682039  25 LECYCQHCS--NfTCsTDGVCLVTVlksgnkIKVEEKLCVAKkDLIPQERPFvCADSIKgdtsvHPKCCYTHMCNK 98  Paramormyrops kings...
KPP64698       1 LECYCHPCS--NaTCqTDGVCYVSIkrsgstITVETKMCIQKkDLFPDGRPFvCTESVKpdvslHPKCCNTDLCNT 74  Asian bonytongue
P36897        34 LQCFCHLCTkdNfTCvTDGLCFVSVtet-tdKVIHNSMCIAEiDLIPRDRPFvCAPSSKtgsvtTTYCCNQDHCNK 108 human

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