3VJ8


Conserved Protein Domain Family
squal_synth

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TIGR01559: squal_synth 
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farnesyl-diphosphate farnesyltransferase
This model describes farnesyl-diphosphate farnesyltransferase, also known as squalene synthase, as found in eukaryotes. This family is related to phytoene synthases. Tentatively identified archaeal homologs (excluded from this model) lack the C-terminal predicted transmembrane region universally conserved among members of this family.
Statistics
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PSSM-Id: 188157
Aligned: 7 rows
Threshold Bit Score: 616.376
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3VJ8_A    11 SSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMES--K 88  human
AAD22408  37 TELRRCYELLDVCSRSFAAVIRELHPEVRDAVMLFYLILRALDTIEDDMTLSRDIKIPILRDFTKCMKTPGWKFTDSdpN 116 Yarrowia lipolytica
P29704    37 PYLLHCFELLNLTSRSFAAVIRELHPELRNCVTLFYLILRALDTIEDDMSIEHDLKIDLLRHFHEKLLLTKWSFDGNapD 116 Saccharomyces cerev...
P37268    38 SSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMES--K 115 human
P53799    35 PHWGFCYSMLHKVSRSFSLVIQQLNTELRNAVCVFYLVLRALDTVEDDTSIPTDEKVPILIAFHRHIYDTDWHYSCG--T 112 thale cress
AAF20201  37 EDRGFCYEILNLVSRSFAIVIQQLPAQLRDPVCIFYLVLRALDTVEDDMKIAATTKIPLLRDFYEKISDRSFRMTAGd-Q 115 Botryococcus braunii
P36596    33 QNIRRCYQLLDMTSRSFAVVIKELPNGIREAVMIFYLVLRGLDTVEDDMTLPLDKKLPILRDFYKTIEVEGWTFNESgpN 112 Schizosaccharomyces...
3VJ8_A    89 EKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSE----Q---EWDKYCHYVAGLVGIGLSRLFS 161 human
AAD22408 117 ERDRVVLQEFPVVMTEFNKLKPKYQEVIYDITDRMGNGMADYVIDDDFNNng-vDtiaAYDLYCHHVAGIVGEGLTRITI 195 Yarrowia lipolytica
P29704   117 VKDRAVLTDFESILIEFHKLKPEYQEVIKEITEKMGNGMADYILDENYNLng-lQtvhDYDVYCHYVAGLVGDGLTRLIV 195 Saccharomyces cerev...
P37268   116 EKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEq-------EWDKYCHYVAGLVGIGLSRLFS 188 human
P53799   113 KEYKILMDQFHHVSAAFLELEKGYQEAIEEITRRMGAGMAKFICQEV-------EtvdDYDEYCHYVAGLVGLGLSKLFL 185 thale cress
AAF20201 116 KDYIRLLDQYPKVTSVFLKLTPREQEIIADITKRMGNGMADFVHKGVP------DtvgDYDLYCHYVAGVVGLGLSQLFV 189 Botryococcus braunii
P36596   113 EKDRQLLVEFDVVIKEYLNLSEGYRNVISNITKEMGDGMAYYASLAEKNDgfsvEtieDFNKYCHYVAGLVGIGLSRLFA 192 Schizosaccharomyces...
3VJ8_A   162 ASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQG---GREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITN 238 human
AAD22408 196 LAGFGTDVLHENPRLQESMGLFLQKVNIIRDYREDIDV---NRAFWPREIWHKYAEEMRDFKDPKYSKKALHCTSDLVAN 272 Yarrowia lipolytica
P29704   196 IAKFANESLYSNEQLYESMGLFLQKTNIIRDYNEDLVD---GRSFWPKEIWSQYAPQLKDFMKPENEQLGLDCINHLVLN 272 Saccharomyces cerev...
P37268   189 ASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQG---GREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITN 265 human
P53799   186 AAGSEVLTPD-WEAISNSMGLFLQKTNIIRDYLEDINEipkSRMFWPREIWGKYADKLEDLKYEENTNKSVQCLNEMVTN 264 thale cress
AAF20201 190 ASGLQSPSLTRSEDLSNHMGLFLQKTNIIRDYFEDINElpaPRMFWPREIWGKYANNLAEFKDPANKAAAMCCLNEMVTD 269 Botryococcus braunii
P36596   193 QSKLEDPDLAHSQAISNSLGLFLQKVNIIRDYREDFDD---NRHFWPREIWSKYTSSFGDLCLPDNSEKALECLSDMTAN 269 Schizosaccharomyces...
3VJ8_A   239 ALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKG---AVKIRKGQAVTLMMDATNMPAVKAIIYQYM 315 human
AAD22408 273 ALGHATDCLDYLDNVTDPSTFTFCAIPQVMAIATLDLVYRNPDVFQK---NVKLRKGTTVSLILEASNVSGVCDIFTRYA 349 Yarrowia lipolytica
P29704   273 ALSHVIDVLTYLAGIHEQSTFQFCAIPQVMAIATLALVFNNREVLHG---NVKIRKGTTCYLILKSRTLRGCVEIFDYYL 349 Saccharomyces cerev...
P37268   266 ALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKG---AVKIRKGQAVTLMMDATNMPAVKAIIYQYM 342 human
P53799   265 ALMHIEDCLKYMVSLRDPSIFRFCAIPQIMAIGTLALCYNNEQVFRG---VVKLRRGLTAKVIDRTKTMADVYGAFYDFS 341 thale cress
AAF20201 270 ALRHAVYCLQYMSMIEDPQIFNFCAIPQTMAFGTLSLCYNNYTIFTGpkaAVKLRRGTTAKLMYTSNNMFAMYRHFLNFA 349 Botryococcus braunii
P36596   270 ALTHATDALVYLSQLKTQEIFNFCAIPQVMAIATLAAVFRNPDVFQT---NVKIRKGQAVQIILHSVNLKNVCDLFLRYT 346 Schizosaccharomyces...
3VJ8_A   316 EEIYHRIPDS---DPSSSKTRQIISTIRTQN 343 human
AAD22408 350 RKVYKKSDPN---DPNYFRVSVLCGKIEQHA 377 Yarrowia lipolytica
P29704   350 RDIKSKLAVQ---DPNFLKLNIQISKIEQFM 377 Saccharomyces cerevisiae S288c
P37268   343 EEIYHRIPDS---DPSSSKTRQIISTIRTQN 370 human
P53799   342 CMLKTKVDKN---DPNASKTLNRLEAVQKLC 369 thale cress
AAF20201 350 EKLEVRCNTEtseDPSVTTTLEHLHKIKAAC 380 Botryococcus braunii
P36596   347 RDIHYKNTPK---DPNFLKISIECGKIEQVS 374 Schizosaccharomyces pombe 972h-
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