"All of Us Research Program, National Institutes of Health"[submitter] - ClinVar - NCBI

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Items: 13

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 1056885	NM_000179.3(MSH6):c.245C>T (p.Pro82Leu)	LOC129933707, MSH6 (P82L)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 954946	NM_000179.3(MSH6):c.246dup (p.Ala83fs)	LOC129933707, MSH6 (A83fs)	Duplication (frameshift variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GPathogenic
Select item 184546	NM_000179.3(MSH6):c.246T>C (p.Pro82=)	LOC129933707, MSH6	Single nucleotide variant (synonymous variant +2 more)	not provided +4 more	GLikely benign
Select item 664593	NM_000179.3(MSH6):c.247G>A (p.Ala83Thr)	LOC129933707, MSH6 (A83T)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 419824	NM_000179.3(MSH6):c.248C>A (p.Ala83Asp)	LOC129933707, MSH6 (A83D)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome +4 more	GUncertain significance
Select item 234750	NM_000179.3(MSH6):c.248C>G (p.Ala83Gly)	LOC129933707, MSH6 (A83G)	Single nucleotide variant (missense variant +2 more)	not provided +3 more	GUncertain significance
Select item 229968	NM_000179.3(MSH6):c.249T>G (p.Ala83=)	LOC129933707, MSH6	Single nucleotide variant (synonymous variant +2 more)	Lynch syndrome 5 +3 more	GConflicting classifications of pathogenicity
Select item 237159	NM_000179.3(MSH6):c.251C>T (p.Ala84Val)	LOC129933707, MSH6 (A84V)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GConflicting classifications of pathogenicity
Select item 410529	NM_000179.3(MSH6):c.254C>T (p.Pro85Leu)	LOC129933707, MSH6 (P85L)	Single nucleotide variant (missense variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GUncertain significance
Select item 184666	NM_000179.3(MSH6):c.255C>G (p.Pro85=)	LOC129933707, MSH6	Single nucleotide variant (synonymous variant +2 more)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 89288	NM_000179.3(MSH6):c.255C>A (p.Pro85=)	LOC129933707, MSH6	Single nucleotide variant (synonymous variant +2 more)	Hereditary nonpolyposis colorectal neoplasms +5 more	GBenign/Likely benign
Select item 856514	NM_000179.3(MSH6):c.259A>C (p.Ser87Arg)	LOC129933707, MSH6 (S87R)	Single nucleotide variant (missense variant +2 more)	Lynch syndrome +1 more	GUncertain significance
Select item 934212	NM_000179.3(MSH6):c.260+4G>A	LOC129933707, MSH6	Single nucleotide variant (intron variant)	Lynch syndrome +2 more	GConflicting classifications of pathogenicity