"All of Us Research Program, National Institutes of Health"[submitter] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 657450	NM_003000.3(SDHB):c.835T>A (p.Ser279Thr)	SDHB (S279T)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GUncertain significance
Select item 3075408	NM_003000.3(SDHB):c.825G>A (p.Glu275=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 855785	NM_003000.3(SDHB):c.823_825del (p.Glu275del)	SDHB (E275del)	Deletion (inframe_deletion)	Hereditary pheochromocytoma-paraganglioma +3 more	GUncertain significance
Select item 3075205	NM_003000.3(SDHB):c.821A>T (p.Lys274Met)	SDHB (K256M +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 459174	NM_003000.3(SDHB):c.820A>G (p.Lys274Glu)	SDHB (K274E)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 3075087	NM_003000.3(SDHB):c.818A>G (p.Tyr273Cys)	SDHB (Y255C +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 486424	NM_003000.3(SDHB):c.818A>T (p.Tyr273Phe)	SDHB (Y273F)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GUncertain significance
Select item 2927111	NM_003000.3(SDHB):c.776C>T (p.Pro259Leu)	SDHB (P241L +1 more)	Single nucleotide variant (missense variant)	Paragangliomas 4 +3 more	GUncertain significance
Select item 1138562	NM_003000.3(SDHB):c.766-9T>G	LOC129929541, SDHB	Single nucleotide variant (intron variant)	Gastrointestinal stromal tumor +3 more	GConflicting classifications of pathogenicity
Select item 1062600	NM_003000.3(SDHB):c.765+6T>C	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma +3 more	GUncertain significance
Select item 412480	NM_003000.3(SDHB):c.765+5G>A	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GConflicting classifications of pathogenicity
Select item 578523	NM_003000.3(SDHB):c.765+4C>T	SDHB	Single nucleotide variant (intron variant)	Paragangliomas 4 +4 more	GConflicting classifications of pathogenicity
Select item 1097988	NM_003000.3(SDHB):c.762T>C (p.Pro254=)	SDHB	Single nucleotide variant (synonymous variant)	Gastrointestinal stromal tumor +4 more	GLikely benign
Select item 183795	NM_003000.3(SDHB):c.758G>A (p.Cys253Tyr)	SDHB (C253Y)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +4 more	GPathogenic/Likely pathogenic
Select item 412482	NM_003000.3(SDHB):c.736A>G (p.Ile246Val)	SDHB (I246V)	Single nucleotide variant (missense variant)	Pheochromocytoma +5 more	GUncertain significance
Select item 2123099	NM_003000.3(SDHB):c.733A>G (p.Thr245Ala)	SDHB (T227A +1 more)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GUncertain significance
Select item 459168	NM_003000.3(SDHB):c.720A>G (p.Leu240=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +4 more	GLikely benign
Select item 412475	NM_003000.3(SDHB):c.716C>T (p.Ser239Phe)	SDHB (S239F)	Single nucleotide variant (missense variant)	Carney-Stratakis syndrome +6 more	GUncertain significance
Select item 233795	NM_003000.3(SDHB):c.713del (p.Phe238fs)	SDHB (F238fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic
Select item 239438	NM_003000.3(SDHB):c.710C>G (p.Pro237Arg)	SDHB (P237R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 293809	NM_003000.3(SDHB):c.700C>T (p.Leu234=)	SDHB	Single nucleotide variant (synonymous variant)	Carney-Stratakis syndrome +6 more	GConflicting classifications of pathogenicity
Select item 185077	NM_003000.3(SDHB):c.688C>T (p.Arg230Cys)	SDHB (R230C)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +5 more	GPathogenic/Likely pathogenic
Select item 412458	NM_003000.3(SDHB):c.687G>C (p.Glu229Asp)	SDHB (E229D)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 3071895	NM_003000.3(SDHB):c.672T>A (p.Asp224Glu)	SDHB (D206E +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 528738	NM_003000.3(SDHB):c.658A>G (p.Ile220Val)	SDHB (I220V)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GUncertain significance
Select item 412491	NM_003000.3(SDHB):c.650G>A (p.Arg217His)	SDHB (R217H)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +5 more	GConflicting classifications of pathogenicity
Select item 183735	NM_003000.3(SDHB):c.649C>T (p.Arg217Cys)	SDHB (R217C)	Single nucleotide variant (missense variant)	Paragangliomas 4 +5 more	GPathogenic/Likely pathogenic
Select item 480804	NM_003000.3(SDHB):c.647A>G (p.Tyr216Cys)	SDHB (Y216C)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 412473	NM_003000.3(SDHB):c.644C>T (p.Ala215Val)	SDHB (A215V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 745505	NM_003000.3(SDHB):c.643-4C>G	SDHB	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +4 more	GLikely benign
Select item 3072659	NM_003000.3(SDHB):c.643-6T>C	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 2154703	NM_003000.3(SDHB):c.643-15T>C	SDHB	Single nucleotide variant (intron variant)	Paragangliomas 4 +3 more	GLikely benign
Select item 438426	NM_003000.3(SDHB):c.642G>C (p.Gln214His)	SDHB (Q214H)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +4 more	GUncertain significance
Select item 230243	NM_003000.3(SDHB):c.640C>T (p.Gln214Ter)	SDHB (Q214*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +6 more	GPathogenic/Likely pathogenic
Select item 41771	NM_003000.3(SDHB):c.638T>C (p.Met213Thr)	SDHB (M213T)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +6 more	GUncertain significance
Select item 239435	NM_003000.3(SDHB):c.607G>A (p.Gly203Arg)	SDHB (G203R)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance
Select item 183747	NM_003000.3(SDHB):c.600G>T (p.Trp200Cys)	SDHB (W200C)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +5 more	GPathogenic/Likely pathogenic
Select item 528727	NM_003000.3(SDHB):c.581C>G (p.Thr194Ser)	SDHB (T194S)	Single nucleotide variant (missense variant)	Pheochromocytoma +5 more	GUncertain significance
Select item 1007903	NM_003000.3(SDHB):c.568G>A (p.Ala190Thr)	SDHB (A190T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 3071935	NM_003000.3(SDHB):c.562C>T (p.Leu188Phe)	SDHB (L170F +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 486418	NM_003000.3(SDHB):c.553G>A (p.Glu185Lys)	SDHB (E185K)	Single nucleotide variant (missense variant)	Pheochromocytoma +5 more	GUncertain significance
Select item 580116	NM_003000.3(SDHB):c.547C>T (p.Leu183Phe)	SDHB (L183F)	Single nucleotide variant (missense variant)	Paragangliomas 4 +4 more	GUncertain significance
Select item 412479	NM_003000.3(SDHB):c.541G>A (p.Asp181Asn)	SDHB (D181N)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GUncertain significance
Select item 412465	NM_003000.3(SDHB):c.541-3C>T	SDHB	Single nucleotide variant (intron variant)	Carney-Stratakis syndrome +5 more	GConflicting classifications of pathogenicity
Select item 1144371	NM_003000.3(SDHB):c.541-5T>C	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GLikely benign
Select item 459155	NM_003000.3(SDHB):c.541-18_541-8dup	SDHB	Duplication (intron variant)	Hereditary pheochromocytoma-paraganglioma +3 more	GLikely benign
Select item 668389	NM_003000.3(SDHB):c.541-10C>T	SDHB	Single nucleotide variant (intron variant)	Gastrointestinal stromal tumor +4 more	GLikely benign
Select item 239433	NM_003000.3(SDHB):c.530G>A (p.Arg177His)	SDHB (R177H)	Single nucleotide variant (missense variant)	not specified +6 more	GUncertain significance
Select item 412469	NM_003000.3(SDHB):c.529C>T (p.Arg177Cys)	SDHB (R177C)	Single nucleotide variant (missense variant)	Pheochromocytoma +5 more	GUncertain significance
Select item 528731	NM_003000.3(SDHB):c.523G>C (p.Glu175Gln)	SDHB (E175Q)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GUncertain significance
Select item 3069734	NM_003000.3(SDHB):c.511C>G (p.Leu171Val)	SDHB (L153V +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 938636	NM_003000.3(SDHB):c.505C>G (p.Gln169Glu)	SDHB (Q169E)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GUncertain significance
Select item 412471	NM_003000.3(SDHB):c.497G>A (p.Gly166Asp)	SDHB (G166D)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 480839	NM_003000.3(SDHB):c.482A>G (p.Asp161Gly)	SDHB (D161G)	Single nucleotide variant (missense variant)	Pheochromocytoma +5 more	GUncertain significance
Select item 3073992	NM_003000.3(SDHB):c.476A>G (p.Lys159Arg)	SDHB (K141R +1 more)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 412466	NM_003000.3(SDHB):c.440A>G (p.Tyr147Cys)	SDHB (Y147C)	Single nucleotide variant (missense variant)	Pheochromocytoma +7 more	GConflicting classifications of pathogenicity
Select item 824752	NM_003000.3(SDHB):c.427T>A (p.Leu143Met)	SDHB (L143M)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 1451060	NM_003000.3(SDHB):c.425A>G (p.Asp142Gly)	SDHB (D142G)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GUncertain significance
Select item 2159832	NM_003000.3(SDHB):c.424-9T>G	SDHB	Single nucleotide variant (intron variant)	Gastrointestinal stromal tumor +3 more	GConflicting classifications of pathogenicity
Select item 44644	NM_003000.2(SDHB):c.424-16_424-14dup	SDHB	Microsatellite (intron variant)	not specified +7 more	GConflicting classifications of pathogenicity
Select item 1548464	NM_003000.3(SDHB):c.424-37TTC[5]	SDHB	Microsatellite (intron variant)	Hereditary pheochromocytoma-paraganglioma +3 more	GLikely benign
Select item 29896	NM_003000.3(SDHB):c.423+1G>A	SDHB	Single nucleotide variant (splice donor variant +1 more)	Paragangliomas 4 +6 more	GPathogenic
Select item 18454	NM_003000.3(SDHB):c.418G>T (p.Val140Phe)	SDHB (V140F)	Single nucleotide variant (missense variant)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 3071913	NM_003000.3(SDHB):c.404T>C (p.Val135Ala)	SDHB (V135A)	Single nucleotide variant (missense variant +1 more)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 824499	NM_003000.3(SDHB):c.400T>C (p.Tyr134His)	SDHB (Y134H)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GUncertain significance
Select item 412452	NM_003000.3(SDHB):c.395A>G (p.His132Arg)	SDHB (H132R)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +6 more	GUncertain significance
Select item 1394716	NM_003000.3(SDHB):c.392C>T (p.Pro131Leu)	SDHB (P131L)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +4 more	GUncertain significance
Select item 183814	NM_003000.3(SDHB):c.380T>G (p.Ile127Ser)	SDHB (I127S)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GPathogenic/Likely pathogenic
Select item 824010	NM_003000.3(SDHB):c.362T>C (p.Leu121Pro)	SDHB (L121P)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GUncertain significance
Select item 3074941	NM_003000.3(SDHB):c.359A>T (p.Asn120Ile)	SDHB (N120I)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 412490	NM_003000.3(SDHB):c.352G>A (p.Asp118Asn)	SDHB (D118N)	Single nucleotide variant (missense variant)	Paragangliomas 4 +4 more	GUncertain significance
Select item 1109722	NM_003000.3(SDHB):c.351T>A (p.Ile117=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma +3 more	GLikely benign
Select item 135193	NM_003000.3(SDHB):c.344G>A (p.Arg115Gln)	SDHB (R115Q)	Single nucleotide variant (missense variant)	Carney-Stratakis syndrome +6 more	GUncertain significance
Select item 953855	NM_003000.3(SDHB):c.331C>G (p.Leu111Val)	SDHB (L111V)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GConflicting classifications of pathogenicity
Select item 1005370	NM_003000.3(SDHB):c.328A>T (p.Thr110Ser)	SDHB (T110S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 656456	NM_003000.3(SDHB):c.323G>A (p.Gly108Asp)	SDHB (G108D)	Single nucleotide variant (missense variant)	Paragangliomas 4 +6 more	GUncertain significance
Select item 412463	NM_003000.3(SDHB):c.317A>G (p.Asn106Ser)	SDHB (N106S)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +6 more	GUncertain significance
Select item 184177	NM_003000.3(SDHB):c.311delinsGG (p.Asn104fs)	SDHB (N104fs)	Indel (frameshift variant)	Hereditary pheochromocytoma-paraganglioma +6 more	GPathogenic
Select item 822717	NM_003000.3(SDHB):c.304G>A (p.Ala102Thr)	SDHB (A102T)	Single nucleotide variant (missense variant)	not provided +6 more	GUncertain significance
Select item 480784	NM_003000.3(SDHB):c.289A>T (p.Ile97Phe)	SDHB (I97F)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GConflicting classifications of pathogenicity
Select item 3075391	NM_003000.3(SDHB):c.288C>T (p.Gly96=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma	GLikely benign
Select item 44642	NM_003000.3(SDHB):c.287-1G>C	SDHB	Single nucleotide variant (splice acceptor variant)	not provided +5 more	GPathogenic/Likely pathogenic
Select item 1125625	NM_003000.3(SDHB):c.287-7C>G	SDHB	Single nucleotide variant (intron variant)	Paragangliomas 4 +3 more	GConflicting classifications of pathogenicity
Select item 1081565	NM_003000.3(SDHB):c.287-9C>G	SDHB	Single nucleotide variant (intron variant)	Gastrointestinal stromal tumor +3 more	GLikely benign
Select item 1580145	NM_003000.3(SDHB):c.287-12T>C	SDHB	Single nucleotide variant (intron variant)	Pheochromocytoma +3 more	GLikely benign
Select item 142111	NM_003000.3(SDHB):c.286G>A (p.Gly96Ser)	SDHB (G96S)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +5 more	GPathogenic/Likely pathogenic
Select item 1043106	NM_003000.3(SDHB):c.280A>G (p.Arg94Gly)	SDHB (R94G)	Single nucleotide variant (missense variant)	Paragangliomas 4 +4 more	GUncertain significance
Select item 1149413	NM_003000.3(SDHB):c.279C>T (p.Cys93=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GLikely benign
Select item 201609	NM_003000.3(SDHB):c.269G>A (p.Arg90Gln)	SDHB (R90Q)	Single nucleotide variant (missense variant)	not provided +5 more	GConflicting classifications of pathogenicity
Select item 3071481	NM_003000.3(SDHB):c.266T>G (p.Phe89Cys)	SDHB (F89C)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 1645710	NM_003000.3(SDHB):c.264C>T (p.Thr88=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma +4 more	GLikely benign
Select item 3074812	NM_003000.3(SDHB):c.262A>G (p.Thr88Ala)	SDHB (T88A)	Single nucleotide variant (missense variant)	Hereditary pheochromocytoma-paraganglioma	GUncertain significance
Select item 656049	NM_003000.3(SDHB):c.234G>T (p.Lys78Asn)	SDHB (K78N)	Single nucleotide variant (missense variant)	Paragangliomas 4 +4 more	GUncertain significance
Select item 640231	NM_003000.3(SDHB):c.231C>G (p.Ile77Met)	SDHB (I77M)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +3 more	GUncertain significance
Select item 417296	NM_003000.3(SDHB):c.225T>C (p.Ala75=)	SDHB	Single nucleotide variant (synonymous variant)	Hereditary pheochromocytoma-paraganglioma +5 more	GLikely benign
Select item 1608839	NM_003000.3(SDHB):c.207C>T (p.Gly69=)	SDHB	Single nucleotide variant (synonymous variant)	Pheochromocytoma +4 more	GLikely benign
Select item 3074069	NM_003000.3(SDHB):c.200+5G>A	SDHB	Single nucleotide variant (intron variant)	Hereditary pheochromocytoma-paraganglioma +1 more	GUncertain significance
Select item 185456	NM_003000.3(SDHB):c.193C>T (p.Leu65Phe)	SDHB (L65F)	Single nucleotide variant (missense variant)	Gastrointestinal stromal tumor +6 more	GUncertain significance
Select item 652669	NM_003000.3(SDHB):c.179C>T (p.Thr60Ile)	SDHB (T60I)	Single nucleotide variant (missense variant)	Pheochromocytoma +4 more	GUncertain significance
Select item 528749	NM_003000.3(SDHB):c.177G>C (p.Gln59His)	SDHB (Q59H)	Single nucleotide variant (missense variant)	not provided +5 more	GUncertain significance

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