"All of Us Research Program, National Institutes of Health"[submitter] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 918953	NM_001018005.2(TPM1):c.-13C>A	TPM1	Single nucleotide variant (5 prime UTR variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 1308976	NM_001018005.2(TPM1):c.1A>G (p.Met1Val)	TPM1 (M1V)	Single nucleotide variant (missense variant +1 more)	not provided +4 more	GUncertain significance
Select item 1374193	NM_001018005.2(TPM1):c.2T>C (p.Met1Thr)	TPM1 (M1T)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy +2 more	GUncertain significance
Select item 3074141	NM_001018005.2(TPM1):c.9C>T (p.Ala3=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 43410	NM_001018005.2(TPM1):c.27G>A (p.Gln9=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +6 more	GConflicting classifications of pathogenicity
Select item 3074310	NM_001018005.2(TPM1):c.36G>A (p.Lys12=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 3072548	NM_001018005.2(TPM1):c.51C>A (p.Asn17Lys)	TPM1 (N17K)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 1102187	NM_001018005.2(TPM1):c.51C>T (p.Asn17=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 181656	NM_001018005.2(TPM1):c.61C>A (p.Arg21=)	TPM1	Single nucleotide variant (synonymous variant)	not specified +2 more	GBenign/Likely benign
Select item 923456	NM_001018005.2(TPM1):c.65C>G (p.Ala22Gly)	TPM1 (A22G)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 926339	NM_001018005.2(TPM1):c.75G>A (p.Ala25=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +1 more	GLikely benign
Select item 923692	NM_001018005.2(TPM1):c.75G>T (p.Ala25=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 3073021	NM_001018005.2(TPM1):c.78G>A (p.Glu26=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 43443	NM_001018005.2(TPM1):c.82G>A (p.Asp28Asn)	TPM1 (D28N)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GUncertain significance
Select item 698113	NM_001018005.2(TPM1):c.87G>A (p.Lys29=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +2 more	GBenign/Likely benign
Select item 2774661	NM_001018005.2(TPM1):c.95C>T (p.Ala32Val)	TPM1 (A32V)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy +1 more	GUncertain significance
Select item 3074695	NM_001018005.2(TPM1):c.105G>A (p.Arg35=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 691665	NM_001018005.2(TPM1):c.105G>C (p.Arg35Ser)	TPM1 (R35S)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 3071288	NM_001018005.2(TPM1):c.114+1G>A	TPM1	Single nucleotide variant (splice donor variant)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 919807	NM_001018005.2(TPM1):c.114+4T>C	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 454414	NM_001018005.2(TPM1):c.115-5C>G	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy +2 more	GUncertain significance
Select item 43403	NM_001018005.2(TPM1):c.118G>T (p.Glu40Ter)	TPM1 (E40* +1 more)	Single nucleotide variant (nonsense +1 more)	Cardiomyopathy +6 more	GUncertain significance
Select item 1171175	NM_001018005.2(TPM1):c.126G>A (p.Glu42=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 1769632	NM_001018005.2(TPM1):c.130G>A (p.Val44Met)	TPM1 (V86M +1 more)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy +1 more	GUncertain significance
Select item 924198	NM_001018005.2(TPM1):c.138G>A (p.Leu46=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 507899	NM_001018005.2(TPM1):c.144G>A (p.Lys48=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +2 more	GLikely benign
Select item 525085	NM_001018005.2(TPM1):c.153G>A (p.Lys51=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 43405	NM_001018005.2(TPM1):c.180C>T (p.Tyr60=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	not specified +3 more	GBenign/Likely benign
Select item 424074	NM_001018005.2(TPM1):c.187G>A (p.Ala63Thr)	TPM1 (A63T +1 more)	Single nucleotide variant (missense variant +1 more)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 3069791	NM_001018005.2(TPM1):c.237C>T (p.Thr79=)	TPM1	Single nucleotide variant (non-coding transcript variant +2 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 3069588	NM_001018005.2(TPM1):c.241-13A>G	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 525116	NM_001018005.2(TPM1):c.241-10C>T	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 43407	NM_001018005.2(TPM1):c.241-9T>C	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy +1 more	GLikely benign
Select item 525088	NM_001018005.2(TPM1):c.241-8C>T	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 316687	NM_001018005.2(TPM1):c.249C>T (p.Ala83=)	TPM1	Single nucleotide variant (synonymous variant)	Dilated cardiomyopathy 1Y +4 more	GConflicting classifications of pathogenicity
Select item 43409	NM_001018005.2(TPM1):c.252C>T (p.Asp84=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +3 more	GLikely benign
Select item 43408	NM_001018005.2(TPM1):c.252C>G (p.Asp84Glu)	TPM1 (D84E +2 more)	Single nucleotide variant (missense variant)	not specified +4 more	GUncertain significance
Select item 181683	NM_001018005.2(TPM1):c.253G>A (p.Val85Ile)	TPM1 (V85I +2 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 3070988	NM_001018005.2(TPM1):c.264G>T (p.Leu88=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 3072014	NM_001018005.2(TPM1):c.270A>G (p.Arg90=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 888353	NM_001018005.2(TPM1):c.271C>T (p.Arg91Cys)	TPM1 (R55C +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy +5 more	GUncertain significance
Select item 920110	NM_001018005.2(TPM1):c.273C>T (p.Arg91=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +2 more	GLikely benign
Select item 3073286	NM_001018005.2(TPM1):c.274A>G (p.Ile92Val)	TPM1 (I134V +2 more)	Single nucleotide variant (non-coding transcript variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 628782	NM_001018005.2(TPM1):c.314G>A (p.Arg105His)	TPM1 (R105H +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 3 +3 more	GUncertain significance
Select item 3074931	NM_001018005.2(TPM1):c.318G>A (p.Leu106=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 3074531	NM_001018005.2(TPM1):c.354G>A (p.Lys118=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 165566	NM_001018005.2(TPM1):c.389T>C (p.Ile130Thr)	TPM1 (I130T +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy +4 more	GConflicting classifications of pathogenicity
Select item 3069216	NM_001018005.2(TPM1):c.397C>T (p.Arg133Ter)	TPM1 (R133* +2 more)	Single nucleotide variant (nonsense +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 3070877	NM_001018005.2(TPM1):c.414A>G (p.Glu138=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 626551	NM_001018005.2(TPM1):c.431A>G (p.Gln144Arg)	TPM1 (Q144R +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy +2 more	GUncertain significance
Select item 3070275	NM_001018005.2(TPM1):c.432G>A (p.Gln144=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 3073114	NM_001018005.2(TPM1):c.436A>T (p.Ile146Phe)	TPM1 (I110F +2 more)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 43418	NM_001018005.2(TPM1):c.444G>C (p.Leu148=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +4 more	GLikely benign
Select item 31888	NM_001018005.2(TPM1):c.453C>A (p.Ala151=)	TPM1	Single nucleotide variant (synonymous variant)	not specified +7 more	GBenign
Select item 2148810	NM_001018005.2(TPM1):c.454A>G (p.Lys152Glu)	TPM1 (K152E +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 702389	NM_001018005.2(TPM1):c.474C>T (p.Ala158=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +4 more	GConflicting classifications of pathogenicity
Select item 31889	NM_001018005.2(TPM1):c.486T>C (p.Tyr162=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +6 more	GBenign/Likely benign
Select item 1634384	NM_001018005.2(TPM1):c.493-13C>T	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 3069359	NM_001018005.2(TPM1):c.493-9C>T	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 644103	NM_001018005.2(TPM1):c.499dup (p.Arg167fs)	TPM1 (R209fs +2 more)	Duplication (frameshift variant)	Cardiovascular phenotype +1 more	GUncertain significance
Select item 3072475	NM_001018005.2(TPM1):c.498C>T (p.Ala166=)	TPM1	Single nucleotide variant (non-coding transcript variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 927037	NM_001018005.2(TPM1):c.507G>C (p.Leu169=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +1 more	GLikely benign
Select item 3070271	NM_001018005.2(TPM1):c.513C>A (p.Ile171=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 31879	NM_001018005.2(TPM1):c.515T>C (p.Ile172Thr)	TPM1 (I172T +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy +2 more	GUncertain significance
Select item 3071679	NM_001018005.2(TPM1):c.528G>A (p.Leu176=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 43424	NM_001018005.2(TPM1):c.548C>T (p.Ala183Val)	TPM1 (A183V +2 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +5 more	GConflicting classifications of pathogenicity
Select item 3074921	NM_001018005.2(TPM1):c.563+5G>A	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 926002	NM_001018005.2(TPM1):c.564-9A>G	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy +1 more	GUncertain significance
Select item 3074870	NM_001018005.2(TPM1):c.574G>T (p.Glu192Ter)	TPM1 (E156* +2 more)	Single nucleotide variant (nonsense +2 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 3073702	NM_001018005.2(TPM1):c.581A>G (p.Glu194Gly)	TPM1 (E158G +2 more)	Single nucleotide variant (missense variant +2 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 181668	NM_001018005.2(TPM1):c.602C>T (p.Thr201Met)	TPM1 (T201M +2 more)	Single nucleotide variant (missense variant +1 more)	Dilated cardiomyopathy 1Y +3 more	GConflicting classifications of pathogenicity
Select item 3071415	NM_001018005.2(TPM1):c.603G>A (p.Thr201=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 43678	NM_001018005.2(TPM1):c.603G>C (p.Thr201=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 3074430	NM_001018005.2(TPM1):c.608A>T (p.Asn203Ile)	TPM1 (N167I +2 more)	Single nucleotide variant (missense variant +2 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 181686	NM_001018005.2(TPM1):c.625G>A (p.Ala209Thr)	TPM1 (A209T +2 more)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 927101	NM_001018005.2(TPM1):c.627T>G (p.Ala209=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 3072395	NM_001018005.2(TPM1):c.628C>T (p.Gln210Ter)	TPM1 (Q174* +2 more)	Single nucleotide variant (nonsense +2 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 924084	NM_001018005.2(TPM1):c.640-14C>G	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 3072399	NM_001018005.2(TPM1):c.640-10C>G	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 1591060	NM_001018005.2(TPM1):c.645G>T (p.Ser215=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 924114	NM_001018005.2(TPM1):c.645G>A (p.Ser215=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 1486721	NM_001018005.2(TPM1):c.647A>G (p.Gln216Arg)	TPM1 (Q216R +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 921255	NM_001018005.2(TPM1):c.660A>G (p.Arg220=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +1 more	GLikely benign
Select item 1094322	NM_001018005.2(TPM1):c.663T>C (p.Tyr221=)	TPM1	Single nucleotide variant (synonymous variant)	not provided +3 more	GBenign/Likely benign
Select item 3073997	NM_001018005.2(TPM1):c.682C>G (p.Leu228Val)	TPM1 (L192V +2 more)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 43434	NM_001018005.2(TPM1):c.684T>C (p.Leu228=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +3 more	GLikely benign
Select item 3075010	NM_001018005.2(TPM1):c.685T>C (p.Ser229Pro)	TPM1 (S193P +2 more)	Single nucleotide variant (non-coding transcript variant +1 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 454420	NM_001018005.2(TPM1):c.687C>T (p.Ser229=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 2918248	NM_001018005.2(TPM1):c.702+6A>G	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 3000074	NM_001018005.2(TPM1):c.703-8C>T	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy	GLikely benign
Select item 967640	NM_001018005.2(TPM1):c.703-3C>T	TPM1	Single nucleotide variant (intron variant)	Cardiovascular phenotype +1 more	GConflicting classifications of pathogenicity
Select item 920908	NM_001018005.2(TPM1):c.703G>A (p.Ala235Thr)	TPM1 (A277T +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy +1 more	GUncertain significance
Select item 43438	NM_001018005.2(TPM1):c.726G>A (p.Ala242=)	TPM1	Single nucleotide variant (synonymous variant)	not specified +4 more	GBenign/Likely benign
Select item 178147	NM_001018005.2(TPM1):c.768A>G (p.Leu256=)	TPM1	Single nucleotide variant (synonymous variant)	not specified +2 more	GLikely benign
Select item 3073123	NM_001018005.2(TPM1):c.773-10del	TPM1	Deletion (3 prime UTR variant +2 more)	Hypertrophic cardiomyopathy	GUncertain significance
Select item 3073525	NM_001018005.2(TPM1):c.773-4A>T	TPM1	Single nucleotide variant (3 prime UTR variant +2 more)	Hypertrophic cardiomyopathy	GLikely benign
Select item 642576	NM_001018005.2(TPM1):c.773-3T>C	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy +3 more	GConflicting classifications of pathogenicity
Select item 626830	NM_001018005.2(TPM1):c.774C>T (p.Asp258=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +2 more	GConflicting classifications of pathogenicity
Select item 43440	NM_001018005.2(TPM1):c.775G>A (p.Glu259Lys)	TPM1 (E259K +1 more)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy +1 more	GUncertain significance
Select item 389247	NM_001018005.2(TPM1):c.783C>T (p.Tyr261=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	not specified +6 more	GLikely benign

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