"Color Diagnostics, LLC DBA Color Health"[submitter] AND "TPM1"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 2774656	NM_001018005.2(TPM1):c.-15C>G	TPM1	Single nucleotide variant (5 prime UTR variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 918953	NM_001018005.2(TPM1):c.-13C>A	TPM1	Single nucleotide variant (5 prime UTR variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 2774657	NM_001018005.2(TPM1):c.-12G>A	TPM1	Single nucleotide variant (5 prime UTR variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 2774658	NM_001018005.2(TPM1):c.-10C>T	TPM1	Single nucleotide variant (5 prime UTR variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 2774659	NM_001018005.2(TPM1):c.-7C>T	TPM1	Single nucleotide variant (5 prime UTR variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 926041	NM_001018005.2(TPM1):c.-7C>A	TPM1	Single nucleotide variant (5 prime UTR variant)	Dilated cardiomyopathy 1Y +2 more	GUncertain significance
Select item 923038	NM_001018005.2(TPM1):c.20_26dup (p.Met10fs)	TPM1 (M10fs)	Duplication (frameshift variant)	Cardiomyopathy	GUncertain significance
Select item 43410	NM_001018005.2(TPM1):c.27G>A (p.Gln9=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +6 more	GConflicting classifications of pathogenicity
Select item 511966	NM_001018005.2(TPM1):c.31C>T (p.Leu11=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +2 more	GLikely benign
Select item 919102	NM_001018005.2(TPM1):c.34A>T (p.Lys12Ter)	TPM1 (K12*)	Single nucleotide variant (nonsense)	Cardiomyopathy	GUncertain significance
Select item 757856	NM_001018005.2(TPM1):c.39C>G (p.Leu13=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +1 more	GLikely benign
Select item 978363	NM_001018005.2(TPM1):c.45G>A (p.Lys15=)	TPM1	Single nucleotide variant (synonymous variant)	not provided +3 more	GBenign/Likely benign
Select item 1743965	NM_001018005.2(TPM1):c.48G>A (p.Glu16=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +1 more	GLikely benign
Select item 181678	NM_001018005.2(TPM1):c.62G>T (p.Arg21Leu)	TPM1 (R21L)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy +7 more	GConflicting classifications of pathogenicity
Select item 923456	NM_001018005.2(TPM1):c.65C>G (p.Ala22Gly)	TPM1 (A22G)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 926339	NM_001018005.2(TPM1):c.75G>A (p.Ala25=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +1 more	GLikely benign
Select item 923692	NM_001018005.2(TPM1):c.75G>T (p.Ala25=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 2774660	NM_001018005.2(TPM1):c.79G>A (p.Ala27Thr)	TPM1 (A27T)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 43444	NM_001018005.2(TPM1):c.82G>C (p.Asp28His)	TPM1 (D28H)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +5 more	GUncertain significance
Select item 43443	NM_001018005.2(TPM1):c.82G>A (p.Asp28Asn)	TPM1 (D28N)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +4 more	GUncertain significance
Select item 1172150	NM_001018005.2(TPM1):c.94G>T (p.Ala32Ser)	TPM1 (A32S)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 2774661	NM_001018005.2(TPM1):c.95C>T (p.Ala32Val)	TPM1 (A32V)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy +1 more	GUncertain significance
Select item 2774662	NM_001018005.2(TPM1):c.100G>A (p.Asp34Asn)	TPM1 (D34N)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 2774663	NM_001018005.2(TPM1):c.103A>C (p.Arg35=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy	GLikely benign
Select item 630593	NM_001018005.2(TPM1):c.104G>A (p.Arg35Lys)	TPM1 (R35K)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 691665	NM_001018005.2(TPM1):c.105G>C (p.Arg35Ser)	TPM1 (R35S)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 408132	NM_001018005.2(TPM1):c.112C>G (p.Gln38Glu)	TPM1 (Q38E)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 646576	NM_001018005.2(TPM1):c.114+3C>T	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 3 +4 more	GUncertain significance
Select item 919807	NM_001018005.2(TPM1):c.114+4T>C	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 137695	NM_001018005.2(TPM1):c.115-335G>T	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy 3 +3 more	GBenign/Likely benign
Select item 629618	NM_001018005.2(TPM1):c.115-334C>T	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy	GLikely benign
Select item 924126	NM_001018005.2(TPM1):c.115-331C>G	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy +1 more	GConflicting classifications of pathogenicity
Select item 627664	NM_001018005.2(TPM1):c.115-331C>T	TPM1	Single nucleotide variant (intron variant)	not provided +1 more	GBenign
Select item 43684	NM_001018005.2(TPM1):c.115-319C>G	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +2 more	GBenign
Select item 43685	NM_001018005.2(TPM1):c.115-316G>A	TPM1	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GBenign/Likely benign
Select item 927336	NM_001018005.2(TPM1):c.115-307C>T	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy	GLikely benign
Select item 918802	NM_001018005.2(TPM1):c.115-277G>A	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy	GLikely benign
Select item 181659	NM_001018005.2(TPM1):c.115-275A>T	TPM1 (E54V)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GConflicting classifications of pathogenicity
Select item 920874	NM_001018005.2(TPM1):c.115-268G>C	TPM1 (E56D)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GLikely benign
Select item 919836	NM_001018005.2(TPM1):c.115-266G>A	TPM1 (R57Q)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GLikely benign
Select item 43686	NM_001018005.2(TPM1):c.115-262C>T	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +2 more	GBenign/Likely benign
Select item 222845	NM_001018005.2(TPM1):c.115-261C>T	TPM1 (R59W)	Single nucleotide variant (missense variant +1 more)	Primary familial hypertrophic cardiomyopathy +1 more	GConflicting classifications of pathogenicity
Select item 507971	NM_001018005.2(TPM1):c.115-244G>A	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +1 more	GLikely benign
Select item 919043	NM_001018005.2(TPM1):c.115-227G>A	TPM1 (S70N)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GLikely benign
Select item 922454	NM_001018005.2(TPM1):c.115-226C>T	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy	GLikely benign
Select item 922144	NM_001018005.2(TPM1):c.115-214C>G	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +1 more	GBenign/Likely benign
Select item 921757	NM_001018005.2(TPM1):c.115-214_115-211delinsT	TPM1 (E76del)	Indel (inframe_deletion +1 more)	Cardiomyopathy	GLikely benign
Select item 921758	NM_001018005.2(TPM1):c.115-213_115-211delinsTT	TPM1 (E75fs)	Indel (frameshift variant +1 more)	Cardiomyopathy	GLikely benign
Select item 922947	NM_001018005.2(TPM1):c.115-193A>C	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy	GLikely benign
Select item 919318	NM_001018005.2(TPM1):c.115-192C>T	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy	GLikely benign
Select item 43403	NM_001018005.2(TPM1):c.118G>T (p.Glu40Ter)	TPM1 (E40* +1 more)	Single nucleotide variant (nonsense +1 more)	Hypertrophic cardiomyopathy +6 more	GUncertain significance
Select item 1171175	NM_001018005.2(TPM1):c.126G>A (p.Glu42=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 924198	NM_001018005.2(TPM1):c.138G>A (p.Leu46=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 507899	NM_001018005.2(TPM1):c.144G>A (p.Lys48=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +2 more	GLikely benign
Select item 1332349	NM_001018005.2(TPM1):c.150C>A (p.Leu50=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 923890	NM_001018005.2(TPM1):c.152A>C (p.Lys51Thr)	TPM1 (K93T +1 more)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 181651	NM_001018005.2(TPM1):c.154G>A (p.Gly52Ser)	TPM1 (G52S +1 more)	Single nucleotide variant (missense variant +1 more)	not provided +1 more	GUncertain significance
Select item 582268	NM_001018005.2(TPM1):c.164A>G (p.Asp55Gly)	TPM1 (D55G +1 more)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy +2 more	GUncertain significance
Select item 525068	NM_001018005.2(TPM1):c.177A>G (p.Lys59=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiovascular phenotype +3 more	GBenign/Likely benign
Select item 43405	NM_001018005.2(TPM1):c.180C>T (p.Tyr60=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	not specified +3 more	GBenign/Likely benign
Select item 843121	NM_001018005.2(TPM1):c.182C>G (p.Ser61Cys)	TPM1 (S61C +1 more)	Single nucleotide variant (missense variant +1 more)	Hypertrophic cardiomyopathy +1 more	GUncertain significance
Select item 925826	NM_001018005.2(TPM1):c.185A>G (p.Glu62Gly)	TPM1 (E62G +1 more)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GUncertain significance
Select item 956455	NM_001018005.2(TPM1):c.196G>C (p.Asp66His)	TPM1 (D108H +1 more)	Single nucleotide variant (missense variant +1 more)	Cardiovascular phenotype +2 more	GUncertain significance
Select item 1332447	NM_001018005.2(TPM1):c.204G>A (p.Gln68=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy +1 more	GLikely benign
Select item 2774664	NM_001018005.2(TPM1):c.207G>T (p.Glu69Asp)	TPM1 (E111D +1 more)	Single nucleotide variant (intron variant +2 more)	Cardiomyopathy	GUncertain significance
Select item 925954	NM_001018005.2(TPM1):c.234C>A (p.Ala78=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Cardiomyopathy	GLikely benign
Select item 628684	NM_001018005.2(TPM1):c.240+4488A>G	LOC130057222, TPM1 +1 more (D22G)	Single nucleotide variant (non-coding transcript variant +2 more)	Cardiomyopathy	GLikely benign
Select item 629720	NM_001018005.2(TPM1):c.240+4545T>C	LOC130057222, TPM1 +1 more (L41P)	Single nucleotide variant (missense variant +1 more)	Cardiomyopathy	GLikely benign
Select item 43407	NM_001018005.2(TPM1):c.241-9T>C	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy +1 more	GLikely benign
Select item 316687	NM_001018005.2(TPM1):c.249C>T (p.Ala83=)	TPM1	Single nucleotide variant (synonymous variant)	Dilated cardiomyopathy 1Y +4 more	GConflicting classifications of pathogenicity
Select item 43409	NM_001018005.2(TPM1):c.252C>T (p.Asp84=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +3 more	GLikely benign
Select item 43408	NM_001018005.2(TPM1):c.252C>G (p.Asp84Glu)	TPM1 (D84E +2 more)	Single nucleotide variant (missense variant)	not specified +4 more	GUncertain significance
Select item 181683	NM_001018005.2(TPM1):c.253G>A (p.Val85Ile)	TPM1 (V85I +2 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 921911	NM_001018005.2(TPM1):c.264G>A (p.Leu88=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy	GLikely benign
Select item 888353	NM_001018005.2(TPM1):c.271C>T (p.Arg91Cys)	TPM1 (R55C +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy +5 more	GUncertain significance
Select item 925303	NM_001018005.2(TPM1):c.272G>A (p.Arg91His)	TPM1 (R55H +2 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +3 more	GUncertain significance
Select item 920110	NM_001018005.2(TPM1):c.273C>T (p.Arg91=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +2 more	GLikely benign
Select item 927033	NM_001018005.2(TPM1):c.288G>A (p.Glu96=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 919295	NM_001018005.2(TPM1):c.294G>A (p.Glu98=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +2 more	GLikely benign
Select item 926294	NM_001018005.2(TPM1):c.301C>G (p.Arg101Gly)	TPM1 (R101G +2 more)	Single nucleotide variant (missense variant)	Cardiomyopathy	GUncertain significance
Select item 1926240	NM_001018005.2(TPM1):c.312G>A (p.Glu104=)	TPM1	Single nucleotide variant (synonymous variant +1 more)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 628782	NM_001018005.2(TPM1):c.314G>A (p.Arg105His)	TPM1 (R105H +2 more)	Single nucleotide variant (missense variant)	Hypertrophic cardiomyopathy 3 +3 more	GUncertain significance
Select item 2413051	NM_001018005.2(TPM1):c.319G>C (p.Ala107Pro)	TPM1 (A107P +2 more)	Single nucleotide variant (missense variant)	Cardiomyopathy +1 more	GUncertain significance
Select item 1172193	NM_001018005.2(TPM1):c.327T>G (p.Ala109=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +1 more	GLikely benign
Select item 1331839	NM_001018005.2(TPM1):c.375-11T>A	TPM1	Single nucleotide variant (intron variant)	Cardiomyopathy	GUncertain significance
Select item 43416	NM_001018005.2(TPM1):c.375-5T>C	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy +4 more	GBenign/Likely benign
Select item 178146	NM_001018005.2(TPM1):c.375-3C>T	TPM1	Single nucleotide variant (intron variant)	Cardiovascular phenotype +5 more	GConflicting classifications of pathogenicity
Select item 165566	NM_001018005.2(TPM1):c.389T>C (p.Ile130Thr)	TPM1 (I130T +2 more)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 925260	NM_001018005.2(TPM1):c.408A>C (p.Lys136Asn)	TPM1 (K100N +2 more)	Single nucleotide variant (missense variant)	Cardiomyopathy	GUncertain significance
Select item 924319	NM_001018005.2(TPM1):c.438C>T (p.Ile146=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiovascular phenotype +2 more	GLikely benign
Select item 43418	NM_001018005.2(TPM1):c.444G>C (p.Leu148=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +4 more	GLikely benign
Select item 31888	NM_001018005.2(TPM1):c.453C>A (p.Ala151=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +7 more	GBenign
Select item 702389	NM_001018005.2(TPM1):c.474C>T (p.Ala158=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +4 more	GConflicting classifications of pathogenicity
Select item 31889	NM_001018005.2(TPM1):c.486T>C (p.Tyr162=)	TPM1	Single nucleotide variant (synonymous variant)	Hypertrophic cardiomyopathy +6 more	GBenign/Likely benign
Select item 928417	NM_001018005.2(TPM1):c.493-7G>A	TPM1	Single nucleotide variant (intron variant)	Hypertrophic cardiomyopathy +2 more	GLikely benign
Select item 43421	NM_001018005.2(TPM1):c.493-6C>T	TPM1	Single nucleotide variant (intron variant)	not specified +4 more	GConflicting classifications of pathogenicity
Select item 927037	NM_001018005.2(TPM1):c.507G>C (p.Leu169=)	TPM1	Single nucleotide variant (synonymous variant)	Cardiomyopathy +1 more	GLikely benign
Select item 43422	NM_001018005.2(TPM1):c.522C>T (p.Ser174=)	TPM1	Single nucleotide variant (synonymous variant)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 12456	NM_001018005.2(TPM1):c.523G>A (p.Asp175Asn)	TPM1 (D175N +2 more)	Single nucleotide variant (missense variant)	Dilated cardiomyopathy 1Y +6 more	GPathogenic
Select item 43424	NM_001018005.2(TPM1):c.548C>T (p.Ala183Val)	TPM1 (A183V +2 more)	Single nucleotide variant (missense variant)	Cardiovascular phenotype +5 more	GConflicting classifications of pathogenicity

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