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Items: 1 to 100 of 2550

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
TMEM240
(F148L)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
SKI
(G117S)
Single nucleotide variant
(missense variant)
Shprintzen-Goldberg syndrome
+1 more
GPathogenic/Likely pathogenic
SKI
(R323L)
Single nucleotide variant
(missense variant)
Shprintzen-Goldberg syndrome
+1 more
GUncertain significance
NPHP4
(V1130G +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GUncertain significance
NPHP4
Single nucleotide variant
(intron variant)
not provided
+1 more
GUncertain significance
NPHP4
Single nucleotide variant
(intron variant)
Nephronophthisis 4
+3 more
GUncertain significance
NPHP4
(H267L)
Single nucleotide variant
(5 prime UTR variant +3 more)
not provided
+3 more
GConflicting classifications of pathogenicity
NPHP4
(A198V)
Single nucleotide variant
(5 prime UTR variant +2 more)
Senior-Loken syndrome 4
+3 more
GUncertain significance
CHD5
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
PARK7
(A36fs)
Duplication
(frameshift variant)
not provided
+1 more
GPathogenic
RERE
(E1191D +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
RERE
(S480N)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
H6PD
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
H6PD
(S685G +1 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GUncertain significance
TARDBP
(I383V)
Single nucleotide variant
(missense variant)
Amyotrophic lateral sclerosis type 10
+3 more
GPathogenic/Likely pathogenic
MASP2, TARDBP
(S506fs)
Duplication
(frameshift variant)
not provided
GLikely pathogenic
MASP2
(R376*)
Single nucleotide variant
(nonsense)
not provided
GLikely pathogenic
MTOR-AS1, MTOR
(T1160S +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
ATP13A2
(P1106L)
Single nucleotide variant
(3 prime UTR variant +1 more)
not provided
GUncertain significance
ATP13A2
(Q635* +1 more)
Single nucleotide variant
(nonsense)
Autosomal recessive spastic paraplegia type 78
+2 more
GPathogenic
ATP13A2
(W578* +1 more)
Single nucleotide variant
(nonsense)
not provided
GLikely pathogenic
ATP13A2
Single nucleotide variant
(intron variant +1 more)
Autosomal recessive spastic paraplegia type 78
+4 more
GPathogenic/Likely pathogenic
PINK1, PINK1-AS
(L347P)
Single nucleotide variant
(non-coding transcript variant +1 more)
Autosomal recessive early-onset Parkinson disease 6
+1 more
GPathogenic
DDOST
(N79S)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
HSPG2, LDLRAD2
Single nucleotide variant
(3 prime UTR variant +1 more)
Schwartz-Jampel syndrome
+4 more
GConflicting classifications of pathogenicity
HSPG2
(A4122T +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
HSPG2
Single nucleotide variant
(synonymous variant)
Lethal Kniest-like syndrome
+3 more
GConflicting classifications of pathogenicity
HSPG2
(N1360D +1 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
HSPG2
(G1050S +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
HSPG2
(P322L)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GUncertain significance
CDC42
(R186H)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
KDM1A
(L511F +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
LDLRAP1, LOC129929773
(G24fs)
Deletion
(frameshift variant)
not provided
+1 more
GPathogenic
LDLRAP1
(Q106*)
Single nucleotide variant
(nonsense)
not provided
GLikely pathogenic
LDLRAP1
(H144fs)
Duplication
(frameshift variant)
Hypercholesterolemia, familial, 4
+1 more
GPathogenic
LDLRAP1
(S202fs)
Duplication
(frameshift variant)
not provided
+1 more
GPathogenic
SELENON
(N238fs +1 more)
Duplication
(frameshift variant)
Eichsfeld type congenital muscular dystrophy
+2 more
GPathogenic
SELENON
(G315S +1 more)
Single nucleotide variant
(missense variant)
not provided
+5 more
GPathogenic/Likely pathogenic
ARID1A
(A1487T)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
ARID1A
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
AHDC1
(V446F)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
AK2
(R103P +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
CSF3R
(C643*)
Single nucleotide variant
(nonsense)
not provided
GLikely pathogenic
MACF1
(R5370Q +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
ZMPSTE24
(L290R)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
CTPS1
Single nucleotide variant
(splice acceptor variant)
Severe combined immunodeficiency due to CTPS1 deficiency
+1 more
GPathogenic
PTCH2
(P206L)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
MUTYH
(A489T +8 more)
Single nucleotide variant
(missense variant +1 more)
not specified
+3 more
GUncertain significance
MUTYH
(G382D +8 more)
Single nucleotide variant
(missense variant +1 more)
Familial adenomatous polyposis 2
+8 more
GPathogenic/Likely pathogenic
MUTYH
Single nucleotide variant
(intron variant)
Familial adenomatous polyposis 2
+2 more
GPathogenic/Likely pathogenic
MUTYH
(Y165C +8 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+3 more
GPathogenic/Likely pathogenic
MUTYH
(W131R +6 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+2 more
GPathogenic/Likely pathogenic
PCSK9
(V81E)
Single nucleotide variant
(missense variant)
Familial hypercholesterolemia
+1 more
GUncertain significance
PCSK9
(Y183C +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
PCSK9
(V233M +5 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
PCSK9
(G240S +5 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
PCSK9
(N254Y +5 more)
Single nucleotide variant
(missense variant)
Hypercholesterolemia, autosomal dominant, 3
+2 more
GUncertain significance
PCSK9
(R357C +5 more)
Single nucleotide variant
(missense variant)
Hypobetalipoproteinemia
+4 more
GConflicting classifications of pathogenicity
C8B
(Q91* +2 more)
Single nucleotide variant
(nonsense)
Type II complement component 8 deficiency
+3 more
GPathogenic/Likely pathogenic
JAK1
(R1112H +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
NEXN
(N46fs)
Deletion
(frameshift variant +1 more)
Hypertrophic cardiomyopathy 20
+2 more
GUncertain significance
NEXN
(R152* +1 more)
Single nucleotide variant
(nonsense)
Dilated cardiomyopathy 1CC
+1 more
GUncertain significance
NEXN
(E267* +1 more)
Single nucleotide variant
(nonsense)
Hypertrophic cardiomyopathy 20
+2 more
GConflicting classifications of pathogenicity
NEXN
(R391* +1 more)
Single nucleotide variant
(nonsense)
Cardiovascular phenotype
+3 more
GConflicting classifications of pathogenicity
NEXN
(R392* +1 more)
Single nucleotide variant
(nonsense)
Primary dilated cardiomyopathy
+6 more
GConflicting classifications of pathogenicity
NEXN
Deletion
(splice donor variant)
Hypertrophic cardiomyopathy 20
+2 more
GLikely pathogenic
NEXN
(R407* +1 more)
Single nucleotide variant
(nonsense)
Cardiovascular phenotype
+1 more
GUncertain significance
NEXN
(Y640fs +1 more)
Deletion
(frameshift variant)
Cardiovascular phenotype
+3 more
GUncertain significance
CDC7
(G67S)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
DIPK1A, RPL5
(V280I)
Single nucleotide variant
(missense variant +2 more)
not provided
+1 more
GUncertain significance
ABCA4
(R212C)
Single nucleotide variant
(missense variant)
Severe early-childhood-onset retinal dystrophy
+5 more
GPathogenic/Likely pathogenic
ABCA4
(L11P)
Single nucleotide variant
(missense variant)
Age related macular degeneration 2
+7 more
GPathogenic/Likely pathogenic
AGL
(Q86* +1 more)
Single nucleotide variant
(nonsense)
Glycogen storage disease type III
+2 more
GPathogenic/Likely pathogenic
AGL
(W680* +4 more)
Single nucleotide variant
(nonsense)
not provided
+1 more
GPathogenic/Likely pathogenic
AGL
(R864* +4 more)
Single nucleotide variant
(nonsense)
Glycogen storage disease type III
+1 more
GPathogenic
COL11A1
(G1139D +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
COL11A1
(D386Y +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
COL11A1
(K262N)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
KCND3
(G581R)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
KCND3
(R426H)
Single nucleotide variant
(missense variant)
Spinocerebellar ataxia type 19/22
+2 more
GUncertain significance
KCND3
(R426C)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
KCND3
(R419H)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
KCND3
(D149G)
Single nucleotide variant
(missense variant)
not specified
+3 more
GUncertain significance
KCND3
(P31L)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
AP4B1-AS1, PTPN22
(S669T +3 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
NRAS
(G12D)
Single nucleotide variant
(missense variant)
not provided
+6 more
GPathogenic/Likely pathogenic
CASQ2
Single nucleotide variant
(splice donor variant)
Catecholaminergic polymorphic ventricular tachycardia 2
+4 more
GPathogenic/Likely pathogenic
CASQ2
(E20*)
Single nucleotide variant
(nonsense)
not provided
GUncertain significance
IGSF3
(D1021fs +1 more)
Deletion
(frameshift variant)
not provided
GLikely pathogenic
GJA5
(D67N)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
CCDST, FLG
(S3145A)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
HAX1
(E31fs)
Deletion
(frameshift variant +1 more)
Kostmann syndrome
+2 more
GPathogenic/Likely pathogenic
GBA1, LOC106627981
(R535H +2 more)
Single nucleotide variant
(missense variant)
Gaucher disease type III
+9 more
GPathogenic/Likely pathogenic
GBA1, LOC106627981
(L483P +2 more)
Single nucleotide variant
(missense variant)
Gaucher disease type III
+14 more
GPathogenic; risk factor
GBA1, LOC106627981
(N409S +2 more)
Single nucleotide variant
(missense variant)
Parkinson disease
+12 more
GPathogenic/Likely pathogenic; risk factor
GBA1, LOC106627981
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
GBA1, LOC106627981
Single nucleotide variant
(intron variant)
not provided
GUncertain significance
GBA1, LOC106627981
(F255Y +2 more)
Single nucleotide variant
(missense variant)
Gaucher disease
+8 more
GPathogenic/Likely pathogenic
GBA1, LOC106627981
(R209C +2 more)
Single nucleotide variant
(missense variant)
Gaucher disease type I
+5 more
GPathogenic/Likely pathogenic
GBA1, LOC106627981
(R115* +2 more)
Single nucleotide variant
(nonsense)
GBA1-related disorder
+9 more
GPathogenic/Likely pathogenic
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