Description
This sequence change replaces asparagine, which is neutral and polar, with lysine, which is basic and polar, at codon 715 of the PACS1 protein (p.Asn715Lys). In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is not expected to disrupt PACS1 protein function. This variant has not been reported in the literature in individuals affected with PACS1-related conditions. This variant is present in population databases (no rsID available, gnomAD 0.0009%).
# | Sample | Method | Observation |
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Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences |
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1 | germline | unknown | not provided | not provided | not provided | | not provided | not provided | not provided | not provided |