ClinVar for Gene (Select 5889) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3342240	GRCh37/hg19 17q22(chr17:56787220-56787351)x1	RAD51C	Copy number loss	not provided	GLikely pathogenic
Select item 3339350	NC_000017.10:g.(56787352_56798106)_(56812973_?)del	RAD51C	Deletion	Hereditary breast ovarian cancer syndrome	GPathogenic
Select item 3312393	NM_058216.3(RAD51C):c.849C>T (p.Thr283=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3312392	NM_058216.3(RAD51C):c.114C>A (p.Leu38=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3312390	NM_058216.3(RAD51C):c.196A>G (p.Arg66Gly)	RAD51C (R66G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3312389	NM_058216.3(RAD51C):c.912T>A (p.Ser304Arg)	RAD51C (S304R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3312387	NM_058216.3(RAD51C):c.498dup (p.Asp167Ter)	RAD51C (D167*)	Duplication (nonsense +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3312386	NM_058216.3(RAD51C):c.318A>G (p.Ala106=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3312385	NM_058216.3(RAD51C):c.572-5T>G	RAD51C	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3312384	NM_058216.3(RAD51C):c.536_544dup (p.Gln181_Leu182insHisLeuGln)	RAD51C	Duplication (inframe_insertion +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3312383	NM_058216.3(RAD51C):c.60T>A (p.Ser20=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3312381	NM_058216.3(RAD51C):c.887T>G (p.Leu296Trp)	RAD51C (L296W)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3256360	NM_058216.3(RAD51C):c.699C>G (p.His233Gln)	LOC129390903, RAD51C (H233Q)	Single nucleotide variant (missense variant +1 more)	not specified	GUncertain significance
Select item 3256359	NM_058216.3(RAD51C):c.572-36C>G	RAD51C	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256358	NM_058216.3(RAD51C):c.146-40C>G	RAD51C	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256357	NM_058216.3(RAD51C):c.146-45T>C	RAD51C	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256224	NM_058216.3(RAD51C):c.*49A>G	RAD51C	Single nucleotide variant (3 prime UTR variant +1 more)	not specified	GLikely benign
Select item 3256217	NM_058216.3(RAD51C):c.905-44A>G	RAD51C	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256213	NM_058216.3(RAD51C):c.837+42G>A	RAD51C	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3256209	NM_058216.3(RAD51C):c.797C>G (p.Ala266Gly)	RAD51C (A266G)	Single nucleotide variant (missense variant +1 more)	not specified	GUncertain significance
Select item 3243093	NC_000017.10:g.(?_56777232)_(56780574_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GLikely pathogenic
Select item 3243092	NC_000017.10:g.(?_56809835)_(56811583_?)dup	RAD51C	Duplication	Fanconi anemia complementation group O	GUncertain significance
Select item 3243091	NC_000017.10:g.(?_56798097)_(56801482_?)dup	RAD51C	Duplication	Fanconi anemia complementation group O	GLikely pathogenic
Select item 3243090	NC_000017.10:g.(?_56770005)_(56801481_?)dup	RAD51C	Duplication	Fanconi anemia complementation group O	GUncertain significance
Select item 3243089	NC_000017.10:g.(?_56769986)_(56772560_?)dup	RAD51C	Duplication	Fanconi anemia complementation group O	GUncertain significance
Select item 3243088	NC_000017.10:g.(?_56769986)_(56811583_?)dup	RAD51C	Duplication	Fanconi anemia complementation group O	GUncertain significance
Select item 3243086	NC_000017.10:g.(?_56809825)_(56811583_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243085	NC_000017.10:g.(?_56801381)_(56811583_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GLikely pathogenic
Select item 3243084	NC_000017.10:g.(?_56787200)_(56811583_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243083	NC_000017.10:g.(?_56780537)_(56787371_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243082	NC_000017.10:g.(?_56770005)_(56787371_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243081	NC_000017.10:g.(?_56769986)_(56772560_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243080	NC_000017.10:g.(?_56809825)_(56809925_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243079	NC_000017.10:g.(?_56780537)_(56780710_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243078	NC_000017.10:g.(?_56770005)_(56811583_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3243077	NC_000017.10:g.(?_56809835)_(56809915_?)del	RAD51C	Deletion	Fanconi anemia complementation group O	GPathogenic
Select item 3242352	GRCh38/hg38 17q22(chr17:58709858-58734223)x1	RAD51C	Copy number loss	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3240253	NM_058216.3(RAD51C):c.268C>A (p.Leu90Ile)	RAD51C (L90I)	Single nucleotide variant (missense variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GUncertain significance
Select item 3240252	NM_058216.3(RAD51C):c.843T>G (p.Ile281Met)	RAD51C (I281M)	Single nucleotide variant (missense variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GUncertain significance
Select item 3236728	NM_058216.3(RAD51C):c.404+44A>G	RAD51C	Single nucleotide variant (3 prime UTR variant +2 more)	Hereditary breast ovarian cancer syndrome	GLikely benign
Select item 3228961	NM_058216.3(RAD51C):c.966-1080C>T	RAD51C	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228958	NM_058216.3(RAD51C):c.863C>T (p.Thr288Ile)	RAD51C (T288I)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228957	NM_058216.3(RAD51C):c.67G>T (p.Val23Leu)	RAD51C (V23L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228956	NM_058216.3(RAD51C):c.596T>C (p.Phe199Ser)	RAD51C (F199S)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228955	NM_058216.3(RAD51C):c.415G>T (p.Ala139Ser)	RAD51C (A139S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228954	NM_058216.3(RAD51C):c.414G>A (p.Leu138=)	RAD51C	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3228953	NM_058216.3(RAD51C):c.365A>G (p.Glu122Gly)	RAD51C (E122G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228952	NM_058216.3(RAD51C):c.341G>A (p.Gly114Glu)	RAD51C (G114E)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228951	NM_058216.3(RAD51C):c.274G>C (p.Glu92Gln)	RAD51C (E92Q)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3228949	NM_058216.3(RAD51C):c.184C>G (p.Gln62Glu)	RAD51C (Q62E)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228948	NM_058216.3(RAD51C):c.17_19del (p.Phe6_Arg7delinsCys)	RAD51C	Deletion (inframe_indel +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228947	NM_058216.3(RAD51C):c.163G>T (p.Ala55Ser)	RAD51C (A55S)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3228946	NM_058216.3(RAD51C):c.145+5C>G	LOC130061310, RAD51C	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228945	NM_058216.3(RAD51C):c.145+177G>T	RAD51C	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228942	NM_058216.3(RAD51C):c.1049T>G (p.Val350Gly)	RAD51C (V350G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3151067	NM_058216.3(RAD51C):c.145+698T>G	RAD51C	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3148765	NM_058216.3(RAD51C):c.706-1G>C	RAD51C	Single nucleotide variant (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GLikely pathogenic
Select item 3148699	NM_058216.3(RAD51C):c.905_908dup (p.Ser304fs)	RAD51C (S304fs)	Duplication (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GLikely pathogenic
Select item 3148679	NM_058216.3(RAD51C):c.858_861dup (p.Thr288fs)	RAD51C (T288fs)	Duplication (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 3148640	NM_058216.3(RAD51C):c.698del (p.His233fs)	LOC129390903, RAD51C (H233fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148634	NM_058216.3(RAD51C):c.478dup (p.Thr160fs)	RAD51C (T160fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148622	NM_058216.3(RAD51C):c.704_705+21del	LOC129390903, RAD51C	Deletion (splice donor variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GLikely pathogenic
Select item 3148608	NM_058216.3(RAD51C):c.699_702del (p.His233fs)	LOC129390903, RAD51C (H233fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148592	NM_058216.3(RAD51C):c.837+1_837+13del	RAD51C	Deletion (splice donor variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GLikely pathogenic
Select item 3148587	NM_058216.3(RAD51C):c.969_977delinsTCTTTAAGCAG (p.Leu323_Leu326delinsPheLeuTer)	RAD51C	Indel (nonsense +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148552	NM_058216.3(RAD51C):c.307_320del (p.Phe103fs)	RAD51C (F103fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148442	NM_058216.3(RAD51C):c.454_460del (p.Ala152fs)	RAD51C (A152fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148426	NM_058216.3(RAD51C):c.242C>G (p.Ser81Ter)	RAD51C (S81*)	Single nucleotide variant (nonsense +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148407	NM_058216.3(RAD51C):c.656dup (p.Leu219fs)	LOC129390903, RAD51C (L219fs)	Duplication (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148400	NM_058216.3(RAD51C):c.361del (p.Thr121fs)	RAD51C (T121fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148369	NM_058216.3(RAD51C):c.388_400del (p.Gly130fs)	RAD51C (G130fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148354	NM_058216.3(RAD51C):c.616dup (p.Ser206fs)	LOC129390903, RAD51C (S206fs)	Duplication (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148351	NM_058216.3(RAD51C):c.449dup (p.Val151fs)	RAD51C (V151fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148336	NM_058216.3(RAD51C):c.238G>T (p.Glu80Ter)	RAD51C (E80*)	Single nucleotide variant (nonsense +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148328	NM_058216.3(RAD51C):c.116_120del (p.Leu39fs)	RAD51C (L39fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148315	NM_058216.3(RAD51C):c.222del (p.Arg74fs)	RAD51C (R74fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148310	NM_058216.3(RAD51C):c.402dup (p.Cys135fs)	RAD51C (W135fs +1 more)	Duplication (frameshift variant +2 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148302	NM_058216.3(RAD51C):c.412_424delinsATC (p.Leu138fs)	RAD51C (L138fs)	Indel (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148220	NM_058216.3(RAD51C):c.405-1G>T	RAD51C	Single nucleotide variant (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 3	GLikely pathogenic
Select item 3148145	NM_058216.3(RAD51C):c.845T>G (p.Leu282Ter)	RAD51C (L282*)	Single nucleotide variant (nonsense +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148144	NM_058216.3(RAD51C):c.833T>G (p.Leu278Ter)	RAD51C (L278*)	Single nucleotide variant (nonsense +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148125	NM_058216.3(RAD51C):c.289C>T (p.Gln97Ter)	RAD51C (Q97*)	Single nucleotide variant (nonsense +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3148029	NM_058216.3(RAD51C):c.630T>A (p.Tyr210Ter)	LOC129390903, RAD51C (Y210*)	Single nucleotide variant (nonsense +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3147978	NM_058216.3(RAD51C):c.293del (p.Gly98fs)	RAD51C (G98fs)	Deletion (frameshift variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 3	GPathogenic
Select item 3022684	NM_058216.3(RAD51C):c.145+12T>C	LOC130061310, RAD51C	Single nucleotide variant (intron variant)	Fanconi anemia complementation group O	GLikely benign
Select item 3015866	NM_058216.3(RAD51C):c.92G>C (p.Gly31Ala)	RAD51C (G31A)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 3009685	NM_058216.3(RAD51C):c.1026+11T>C	RAD51C	Single nucleotide variant (intron variant)	Fanconi anemia complementation group O	GLikely benign
Select item 2999555	NM_058216.3(RAD51C):c.571+13A>G	RAD51C	Single nucleotide variant (intron variant)	Fanconi anemia complementation group O	GLikely benign
Select item 2999511	NM_058216.3(RAD51C):c.728G>C (p.Gly243Ala)	RAD51C (G243A)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 2996623	NM_058216.3(RAD51C):c.122T>C (p.Val41Ala)	RAD51C (V41A)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 2996399	NM_058216.3(RAD51C):c.145+10C>G	LOC130061310, RAD51C	Single nucleotide variant (intron variant)	Fanconi anemia complementation group O	GLikely benign
Select item 2988609	NM_058216.3(RAD51C):c.814C>T (p.Leu272Phe)	RAD51C (L272F)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 2987871	NM_058216.3(RAD51C):c.34C>A (p.Arg12=)	RAD51C	Single nucleotide variant (synonymous variant +1 more)	Fanconi anemia complementation group O	GLikely benign
Select item 2981918	NM_058216.3(RAD51C):c.379C>G (p.Pro127Ala)	RAD51C (P127A)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 2980685	NM_058216.3(RAD51C):c.905-16T>C	RAD51C	Single nucleotide variant (intron variant)	Fanconi anemia complementation group O	GLikely benign
Select item 2977519	NM_058216.3(RAD51C):c.992G>C (p.Ser331Thr)	RAD51C (S331T)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 2974391	NM_058216.3(RAD51C):c.637T>C (p.Cys213Arg)	LOC129390903, RAD51C (C213R)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 2972449	NM_058216.3(RAD51C):c.572-14T>G	RAD51C	Single nucleotide variant (intron variant)	Fanconi anemia complementation group O	GLikely benign
Select item 2964839	NM_058216.3(RAD51C):c.698A>C (p.His233Pro)	LOC129390903, RAD51C (H233P)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance
Select item 2963873	NM_058216.3(RAD51C):c.298A>G (p.Ile100Val)	RAD51C (I100V)	Single nucleotide variant (missense variant +1 more)	Fanconi anemia complementation group O	GUncertain significance

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