Literature
PubMed
PubMed® comprises more than 37 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
Literature databases
Books and reports
Ontology used for PubMed indexing
Books, journals and more in the NLM Collections
Scientific and medical abstracts/citations
Full-text journal articles
Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Collected information about gene loci
Functional genomics studies
Gene expression and molecular abundance profiles
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved protein domains
Protein sequences grouped by identity
Protein sequences
Models representing homologous proteins with a common function
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
Search nucleotide sequence databases
Search protein sequence databases
Search protein databases using a translated nucleotide query
Search translated nucleotide databases using a protein query
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Genome assembly information
Museum, herbaria, and other biorepository collections
Biological projects providing data to NCBI
Descriptions of biological source materials
Genome sequencing projects by organism
DNA and RNA sequences
High-throughput sequence reads
Taxonomic classification and nomenclature
Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
Privately and publicly funded clinical studies conducted around the world
Human variations of clinical significance
Genotype/phenotype interaction studies
Short genetic variations
Genome structural variation studies
Genetic testing registry
Medical genetics literature and links
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
Bioactivity screening studies
Chemical information with structures, information and links
Molecular pathways with links to genes, proteins and chemicals
Deposited substance and chemical information
News
Research news
A scientist took a psychedelic drug — and watched his own brain 'fall apart'
Scientists scanned the brains of people who took psilocybin, including a member of the research team. The scans showed how the drug disrupts key networks, potentially enhancing brain plasticity.
Crows can count out loud like human toddlers — when they aren't cheating the test
A study finds that carrion crows can be taught to count and make vocalizations that indicate the number counted, much in the same way that human toddlers do.
About 7 percent of U.S. adults have had long covid, report says
Just 6 percent of the vaccinated and boosted respondents reported long covid symptoms vs. 8 percent of those who weren’t vaccinated.
Recent blog posts
Open Access! Million Veteran Program Genome-Wide PheWAS Results Now Available in dbGaP!
The Million Veteran Program (MVP) is a research program from the U.S. Department of Veterans Affairs (VA) that has collected and analyzed health information from over one million veteran volunteers. The data include genes, lifestyles, military experiences, and exposures that may impact health and wellness. The results of the MVP phenome-wide association study (PheWAS) … Continue reading Open Access! Million Veteran Program Genome-Wide PheWAS Results Now Available in dbGaP!
Get Faster, More Focused Search Results with NCBI’s New BLAST Core Nucleotide Database (core_nt)
Effective August 2024, core_nt will become the default Interested in faster nucleotide BLAST searches with more focused search results? As previously announced, NCBI has been re-evaluating the BLAST nucleotide database (nt) to make it more compact and more efficient. Thanks to your feedback, NCBI’s BLAST is excited to introduce the core nucleotide database (core_nt), an … Continue reading Get Faster, More Focused Search Results with NCBI’s New BLAST Core Nucleotide Database (core_nt)
Study of Protective Gene Variant Provides Insight into Delaying Onset of Alzheimer’s Dementia
Alzheimer’s disease is currently the seventh leading cause of death in the U.S. While your likelihood of developing Alzheimer’s-related cognitive impairment increases with age, risk for this disease and age of its onset depend on many factors, including the genes you carry. An intriguing new study suggests that having just one copy of a protective gene variant may be enough to delay cognitive impairment from this devastating disease in individuals who are otherwise genetically predisposed to developing early-onset Alzheimer’s dementia. The findings, from a study supported in part by NIH and reported in The New England Journal of Medicine, offer important insights into the genetic factors and underlying pathways involved in Alzheimer’s dementia. While much more study is needed, the findings have potential implications for treatments that could one day work like this gene variant does to delay or perhaps even prevent Alzheimer’s dementia.