(txid32524[Organism:exp]) AND gds_sra[filter] - GEO DataSets

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Select item 2002453841.

Keratin 17- and PKCα-dependent transient amplification of neutrophil influx after repeated stress to the skin

(Submitter supplied) Neutrophils contribute to the pathogenesis of chronic inflammatory skin diseases. Little is known about the source and identity of the signals mediating their recruitment in inflamed skin. We used the phorbol ester TPA and UVB, alone or in combination, to induce sterile inflammation in mouse skin and assess whether keratinocyte-derived signals impact neutrophil recruitment. A single TPA treatment results in a neutrophil influx in the dermis that peaks at 12h and resolves within 24h. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TSV

Series

Accession:: GSE245384

ID:: 200245384

Select item 2001611652.

Transcriptomic changes in mouse Epiblast stem cells induced with Mixl1

(Submitter supplied) We performed total RNA-seq in a epiblast stem cell model of mouse gastrulation to determine the effect of Mixl1 knockout and induction.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
6 Samples

Download data: TAB, TSV

Series

Accession:: GSE161165

ID:: 200161165

SRA Run Selector

Select item 2001611643.

Chromatin immunoprecipitation in mouse Epiblast stem cells induced with FLAG-Mixl1

(Submitter supplied) We performed ChIP-seq in a epiblast stem cell model of mouse gastrulation to identify the genomic binding locations of mouse MIXL1

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: BED

Series

Accession:: GSE161164

ID:: 200161164

SRA Run Selector

Select item 2001611634.

Chromatin accessibility in mouse Epiblast stem cells induced with Mixl1

(Submitter supplied) We performed ATAC-seq in a epiblast stem cell model of mouse gastrulation to determine the effect of Mixl1 knockout and induction on chromatin accessibility.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
6 Samples

Download data: NARROWPEAK

Series

Accession:: GSE161163

ID:: 200161163

SRA Run Selector

Select item 2002322845.

The effect of ITPRIPL2 knockdown on the transcriptome in nHDF and HeLa cells

(Submitter supplied) To investigate the general effect of ITPRIPL2 knockdown on the transcription profile, we generated transient ITPRIPL2 knockdowns in nHDF and HeLa cells. Gene expression analysis was performed on RNA-seq data from four biological replicates of cells harvested 72 hours post transfection with esiRNAs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
16 Samples

Download data: TXT

Series

Accession:: GSE232284

ID:: 200232284

Analyze with GEO2R

Select item 2002721716.

Cryopreservation of stem cell-derived beta-like cells enriches for beta cells with improved function

(Submitter supplied) The generation of stem cell-derived beta-like cells (sBC) holds extreme promise as not only an abundant insulin-producing cell source for replacement therapy of Type 1 diabetes (T1D), but also as an invaluable model system for investigating human beta cell development, immunogenicity, and function. Several groups have developed methodology to direct differentiate human pluripotent stem cells into pancreatic cell populations that include glucose responsive sBC. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: CLOUPE, CSV, H5

Series

Accession:: GSE272171

ID:: 200272171

Select item 2002721687.

Life long effects of radiation and high fat dieat on the mouse left ventricular tissue

(Submitter supplied) We studied the long-term effects of single whole-body gamma and simulated GCR irradiation (IR) and consumption of a Western Diet (WD) on the heart's left ventricle (LV). Three-month-old C57Bl/6J wild-type male and female mice were assigned to the following groups: 1) Gamma-irradiated with follow-up at 440(males and females) and 660(males)/550(females) days post-IR; 2) simGCRsim-irradiated with follow-up at 440(males and females) and 660(males)/550(females) days post-IR; 3) 270-days WD-fed animals with followup at 530 (males and females) and 750(males)/640(females). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
80 Samples

Download data: TSV

Series

Accession:: GSE272168

ID:: 200272168

Select item 2002721338.

Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes

(Submitter supplied) Bariatric surgery is highly effective for the treatment of obesity in individuals without (OB ) and in those with type 2 diabetes (T2D ). However, whether bariatric surgery triggers similar or distinct molecular changes in OB and T2D remains unknown. Given that individuals with type 2 diabetes often exhibit more severe metabolic deterioration, we hypothesized that bariatric surgery induces distinct molecular adaptations in skeletal muscle, the major site of glucose uptake, of OB and T2D after surgery-induced weight loss. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28038
52 Samples

Download data: TSV

Series

Accession:: GSE272133

ID:: 200272133

Analyze with GEO2R

Select item 2002719039.

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury

(Submitter supplied) Osteoarthritis (OA) is a disease with sex-dependent prevalence and severity in both human and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic OA (PTOA).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28457
61 Samples

Download data: XLSX

Series

Accession:: GSE271903

ID:: 200271903

Select item 20026987810.

Single cell RNA sequencing of nc886, a non-coding RNA transcribed by RNA polymerase III, with a primer spike-in strategy

(Submitter supplied) Single cell RNA sequencing (scRNA-seq) has emerged as a versatile tool in biology, enabling comprehensive genomic-level characterization of individual cells. Currently, most scRNA-seq methods generate barcoded cDNAs by capturing polyA tails of mRNAs, which excludes many non-coding RNAs (ncRNAs), especially those transcribed by RNA polymerase III (Pol III). Although previously thought to be expressed constitutively, Pol III-transcribed ncRNAs are expressed variably in healthy and disease states and play important roles therein, necessitating their profiling at the single cell level. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL20795
2 Samples

Download data: CSV, RDS

Series

Accession:: GSE269878

ID:: 200269878

Select item 20026598711.

ChIP-seq analysis of histone variant H2BE in neuronal chromatin

(Submitter supplied) ChIP-seq analysis of histone variant H2BE in neuronal chromatin

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL32159
6 Samples

Download data: BW

Series

Accession:: GSE265987

ID:: 200265987

Select item 20026598612.

ATAC-seq analysis of mutant histone variant H2BE in neuronal chromatin

(Submitter supplied) ATAC-seq analysis of mutant histone variant H2BE in neuronal chromatin

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL32159
6 Samples

Download data: BW

Series

Accession:: GSE265986

ID:: 200265986

Select item 20025361013.

Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA) with leptomeningeal dissemination and ZMIZ1::RET fusion [RNA-seq]

(Submitter supplied) Herein we describe a case with histological, immunohistochemical and molecular features of GTAKA showing widespread leptomeningeal dissemination.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
1 Sample

Download data: TSV

Series

Accession:: GSE253610

ID:: 200253610

Analyze with GEO2R

Select item 20024734014.

Single-nucleus transcriptomic analysis of cortical tissue from WT and H2BE-KO young adult mice

(Submitter supplied) Single-nucleus Drop-seq was used to profile transcriptional changes upon loss of H2BE in nuclei isolated from the cortex of young adult mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE247340

ID:: 200247340

Select item 20024674815.

CUT&Tag seq analysis of histone variant H2BE in neurons [H2BE_CT_antibodyValidation]

(Submitter supplied) Analysis of histone variant H2BE in neuronal chromatin

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
3 Samples

Download data: TDF

Series

Accession:: GSE246748

ID:: 200246748

Select item 20024673916.

ATAC-seq analysis of histone variant H2BE in neuronal chromatin

(Submitter supplied) ATAC-seq analysis of histone variant H2BE in neuronal chromatin

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
25 Samples

Download data: BW

Series

Accession:: GSE246739

ID:: 200246739

Select item 20024668717.

Analysis of histone variant H2BE in neuronal chromatin

(Submitter supplied) WT and H2BE-KO primary cortical neurons were isolated from E16.5 mice and culture for 12 days for ATAC-sequencing (n=3 WT biological replicates, 4 KO biological replicates).

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
7 Samples

Download data: BW

Series

Accession:: GSE246687

ID:: 200246687

Select item 20024668618.

RNA-seq analysis of WT and H2BE-KO primary cortical neurons

(Submitter supplied) Effect of H2BE loss on neuronal transcription

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32159
8 Samples

Download data: CSV

Series

Accession:: GSE246686

ID:: 200246686

Select item 20024661819.

CUT&Tag seq analysis of histone variant H2BE in neurons

(Submitter supplied) Histone variant H2BE Analysis of histone variant H2BE in neuronal chromatin

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
6 Samples

Download data: BW

Series

Accession:: GSE246618

ID:: 200246618

Select item 20022991020.

DDX24 Promotes Lymphangiogenesis and Lymph Node Metastasis via AGRN Production in Cervical Squamous Cell Carcinoma

(Submitter supplied) To investigate the factor produced by CSCC cells to facilitate lymphangiogenesis, we analyzed the transcriptomics of CSCC cells upon DDX24 has been knocked down by siRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cell lines.