GEO DataSets

(Submitter supplied) Analysis of gene expression changes that occur in pancreatic tumors when global TBK1 is lost.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

6 Samples

Download data: IDAT, TXT

(Submitter supplied) Objective: Monocytes are crucially involved in inflammatory processes. In mice, different subsets of monocytes can be distinguished by the expression of Ly6C, a surface marker that is highly expressed on inflammatory monocytes (Ly6C high) and to a lesser extent on patrolling monocytes (Ly6C low). Our previous study revealed an aggravated accumulation of inflammatory Ly6C high monocytes in atherosclerotic-prone mice bearing a deficiency in suppressor of cytokine signaling (Socs)-1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

33 Samples

Download data: IDAT, TXT

(Submitter supplied) Transcriptome analysis was used to identify changes in mouse kidney cancer cells (RENCA) resistant to sunitinib (SuR) and after short and long term sunitinib withdrawal in vitro (ST-W for 48 hours and LT-W for more than 2 months, respectively).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

12 Samples

Download data: TXT

(Submitter supplied) Transcriptome analysis was used to identify changes in mouse fibroblasts (3T3) resistant to sunitinib (SuR) and after short and long term sunitinib withdrawal in vitro (ST-W for 48 hours and LT-W for more than 2 months, respectively).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

12 Samples

Download data: TXT

(Submitter supplied) Toll-like receptor 5 is considered an attractive target for anticancer immunotherapy. TLR5 agonists, bacterial flagellin and engineered flagellin derivatives, have been shown to have potent anti-tumor and metastasis-suppressive effects in multiple animal models and to be safe in both animals and humans. Anticancer efficacy of TLR5 agonists stems from TLR5-dependent activation of NF-kB that mediates innate and adaptive anti-tumor immune responses. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

12 Samples

Download data: TXT

(Submitter supplied) TRAF6 -/- thymi display defects in IR-induced p53 target gene expression and attenuate further enhancement of apoptosis upon IR treatment. TRAF6-mediated K63-linked ubiquitination of p53 at K24

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL18752 GPL10904

8 Samples

Download data: IDAT, TXT

(Submitter supplied) Analysis of gene expression of mouse mammary tumors with different SphK1 expressions. The hypothesis tested in this study is that SphK1 deletion in mice influence the cancer promoting/inhibiting genes.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

12 Samples

Download data: TXT

(Submitter supplied) Transcriptional regulation of genes in AML12 cells treated with Palmitic acid, LXR lingand (GW3965) and Ulk1 siRNA shows differential effect of Ulk1 KD on LXr responsive genes

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

12 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus; Mus musculus

Type:

Expression profiling by array; Expression profiling by RT-PCR

Platforms:

GPL18752 GPL22820

15 Samples

Download data: IDAT

(Submitter supplied) Chronic kidney disease is associated with progressive renal fibrosis, where perivascular cells give rise to the majority of α-SMA positive myofibroblasts. We sought to identify pericytic miRNAs that could serve as a target to decrease myofibroblast formation. We induced kidney fibrosis in FoxD1-GC;Z/Red-mice by unilateral ureteral obstruction (UUO) followed by FACS sorting of dsRed-positive FoxD1-derivative cells and miRNA profiling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

8 Samples

Download data: IDAT, TXT

(Submitter supplied) The downstream events and target genes of p53 in the process of senescence are not fully understood. Here, we report a novel function of the forkhead transcription factor Foxp3, which is a key player in mediating T cell inhibitory functions, in p53-mediated cellular senescence. The overexpression of Foxp3 in mouse embryonic fibroblasts (MEFs) accelerates senescence, whereas Foxp3 knockdown leads to escape from p53-mediated senescence in p53-expressing MEFs. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL18752 GPL10904 GPL11202

10 Samples

Download data: IDAT, TXT

(Submitter supplied) Diverse populations of natural killer cells, which exert critical early cytolytic functions against virally infected cells, have recently been uncovered, raising issues of lineage relationships. We used expression of the transcription factor PLZF to identify the developmental intermediates of ILC1s, a subset of natural killer-like cells that are particularly abundant in the liver, and demonstrated a distinct precursor but parallel development and partial overlap with established classical NK stages. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

8 Samples

Download data: IDAT, TXT

(Submitter supplied) ErbB2-induced mouse mammary tumors can originate from different mammary epithelial cells, including both basal epithelial cells and luminal progenitors. Here we used the tumors from basal cells or luminal progenitors to compare the difference in transcripts.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

12 Samples

Download data: TXT

(Submitter supplied) Triple negative breast cancer (TNBC) has poor prognostic outcome compared to other types of breast cancer1. At present the molecular and cellular mechanisms underlying TNBC pathology are not well understood1. Here we report that the transcription factor BCL11A is overexpressed in TNBC including basal-like breast cancer (BLBC) and that its genomic locus is amplified in up to 38% of BLBC tumours. BCL11A overexpression in immortalised human breast epithelial cells promotes tumour formation in xenograft models, whereas knockdown of BCL11A in TNBC cell lines suppresses their tumourigenic potential. In the DMBA-induced mouse mammary tumour model, Bcl11a is found to be essential for tumourigenesis since deletion of Bcl11a before DMBA treatment substantially decreases tumour formation, even in p53-null cells, and inactivation of Bcl11a in established tumours causes their regression. At the cellular level, BCL11A overexpression enhances clonogenicity in vitro whereas its deletion in the mouse causes a reduction in the number of mammary epithelial stem and progenitor cells. Thus, BCL11A has an important role in the genesis of TNBC and in normal mammary epithelial cells. This study highlights the importance of further investigation of BCL11A in breast cancer diagnosis and targeted therapies.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10904 GPL18752

7 Samples

Download data: TXT

(Submitter supplied) Comparison of gene expression changes in Ptch-deficient mouse medulloblastoma cell line SmoWT-MB upon treatment with SMOi GDC-0449 or BETi JQ1. The hypothesis is that they can both inhibit the expressions of Hh signaling target genes in this Hh-driven tumor cell line.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18752

6 Samples

Download data: TXT