GPL20051[Accession] - GEO DataSets

Select item 2001172561.

Role of ProQ in Salmonella virulence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20056 GPL20051
42 Samples

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Series

Accession:: GSE117256

ID:: 200117256

PubMed Full text in PMC Similar studies

Select item 2001172362.

Role of ProQ in Salmonella virulence - dual RNA-Seq

(Submitter supplied) FinO-domain proteins such as ProQ of the model pathogen Salmonella enterica have emerged as a new class of major RNA-binding proteins in bacteria. ProQ has been shown to target hundreds of transcripts including mRNAs from many virulence regions but its role, if any, in bacterial pathogenesis has not been studied. Here, using a Dual RNA-seq approach to profile ProQ-dependent gene expression changes as Salmonella infects human cells, we reveal dysregulation of bacterial motility, chemotaxis and virulence genes which is accompanied by altered mitogen-activated protein kinase signaling in the host. more...

Organism:: Homo sapiens; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20051
12 Samples

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Series

Accession:: GSE117236

ID:: 200117236

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000679523.

Dual RNA-seq – Dual RNA-seq of further sRNA mutants

(Submitter supplied) Bacteria possess many small noncoding RNAs whose regulatory roles in pathogenesis are little understood due to a paucity of macroscopic phenotypes in standard virulence assays. Here, we use a novel Dual RNA-seq approach for a single-step simultaneous RNA profiling in both pathogen and host to reveal molecular phenotypes of sRNAs during infection with Salmonella Typhimurium. We identify a new PhoP/Q-activated small RNA which upon bacterial internalization acts to temporally control the expression of both, invasion-associated effectors and virulence genes required for intracellular survival. more...

Organism:: Homo sapiens; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20050 GPL20051
42 Samples

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Series

Accession:: GSE67952

ID:: 200067952

PubMed Similar studies SRA Run Selector

Select item 2000679474.

Dual RNA-seq – sRNA profiling in various cell types

(Submitter supplied) Bacteria possess many small noncoding RNAs whose regulatory roles in pathogenesis are little understood due to a paucity of macroscopic phenotypes in standard virulence assays. Here, we use a novel Dual RNA-seq approach for a single-step simultaneous RNA profiling in both pathogen and host to reveal molecular phenotypes of sRNAs during infection with Salmonella Typhimurium. We identify a new PhoP/Q-activated small RNA which upon bacterial internalization acts to temporally control the expression of both, invasion-associated effectors and virulence genes required for intracellular survival. more...

Organism:: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Homo sapiens; Sus scrofa; Mus musculus

Type:: Expression profiling by high throughput sequencing

6 related Platforms
89 Samples

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Series

Accession:: GSE67947

ID:: 200067947

PubMed Similar studies SRA Run Selector

Select item 2000677595.

Dual RNA-seq – rRNA depletion establishment

(Submitter supplied) Bacteria possess many small noncoding RNAs whose regulatory roles in pathogenesis are little understood due to a paucity of macroscopic phenotypes in standard virulence assays. Here, we use a novel Dual RNA-seq approach for a single-step simultaneous RNA profiling in both pathogen and host to reveal molecular phenotypes of sRNAs during infection with Salmonella Typhimurium. We identify a new PhoP/Q-activated small RNA which upon bacterial internalization acts to temporally control the expression of both, invasion-associated effectors and virulence genes required for intracellular survival. more...

Organism:: Homo sapiens; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20051
2 Samples

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Series

Accession:: GSE67759

ID:: 200067759

PubMed Similar studies SRA Run Selector

Select item 2000677586.

Dual RNA-seq – High-resolution comparative Dual RNA-seq time-course

(Submitter supplied) Bacteria possess many small noncoding RNAs whose regulatory roles in pathogenesis are little understood due to a paucity of macroscopic phenotypes in standard virulence assays. Here, we use a novel Dual RNA-seq approach for a single-step simultaneous RNA profiling in both pathogen and host to reveal molecular phenotypes of sRNAs during infection with Salmonella Typhimurium. We identify a new PhoP/Q-activated small RNA which upon bacterial internalization acts to temporally control the expression of both, invasion-associated effectors and virulence genes required for intracellular survival. more...

Organism:: Homo sapiens; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL20051
51 Samples

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Series

Accession:: GSE67758

ID:: 200067758

PubMed Similar studies SRA Run Selector

Select item 2000601447.

Dual RNA-seq of diverse human, mouse and pig cell-types infected with various Salmonella strains

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Sus scrofa; Mus musculus; Salmonella enterica subsp. enterica serovar Typhimurium