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Influenza defective interfering virus promotes multiciliated cell differentiation and reduces the inflammatory response in mice

(Submitter supplied) Influenza defective interfering (DI) viruses have long been considered promising antiviral candidates because of their ability to interfere with replication-competent viruses and to induce antiviral immunity. However, the mechanisms underlying DI-mediated antiviral immunity have not been extensively explored. Here, we demonstrated interferon (IFN) independent protection conferred by influenza DI virus against homologous virus infection in mice deficient in type I and III IFN signaling. more...
Organism:
Mus musculus; Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Type:
Expression profiling by high throughput sequencing; Other; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL19057 GPL30927 GPL30928
155 Samples
Download data: TXT
Series
Accession:
GSE188122
ID:
200188122

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