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Items: 2

1.

Gene expression response to the antifungal compound sampangine

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...
Organism:
Saccharomyces cerevisiae; Candida albicans
Type:
Expression profiling by array
Platforms:
GPL6346 GPL90
9 Samples
Download data: CEL, TXT
Series
Accession:
GSE10104
ID:
200010104
2.

Gene expression response to the antifungal compound sampangine in C. albicans

(Submitter supplied) Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analysis of mutants were performed in an effort to elucidate its mechanism of action. Using Saccharomyces cerevisiae as a model organism, we show that sampangine produces a transcriptional response indicative of hypoxia, altering the expression of genes known to respond to low oxygen conditions. more...
Organism:
Candida albicans
Type:
Expression profiling by array
Platform:
GPL6346
3 Samples
Download data: TXT
Series
Accession:
GSE10075
ID:
200010075

Supplemental Content

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