GSE21550[Accession] - GEO DataSets - NCBI

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Items: 15

Select item 2000215501.

Effect of Protease-resistant PML-RARα on the leukemogenic potential in a mouse model of Acute Promyelocytic Leukemia

(Submitter supplied) Previous studies in our laboratory demonstrated that the azurophil granule protease neutrophil elastase (NE) cleaves PML-RARA (PR), the fusion protein that initiates acute promyelocytic leukemia (APL). Further, NE deficiency reduces the penetrance of APL in a murine model of this disease. We therefore predicted that NE-mediated PR cleavage might be important for its ability to initiate APL. To test this hypothesis, we generated a mouse expressing NE-resistant PR. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4172
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE21550

ID:: 200021550

Analyze with GEO2R

Select item 41722.

Full record GDS4172

Effect of protease-resistant (PML-RAR)α on U937 cell line

Analysis of U937 cells transfected with GFP-(PML-RAR)α (PR) or GFP-PR2VR (cleavage-resistant mutant) and GFP-sorted at 6 and 9 hrs. Neutrophil elastase (NE) cleaves PR, the fusion protein that initiates acute promyelocytic leukemia. Results provide insight into leukemogenicity of NE-resistant PR.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 genotype/variation, 2 time sets

Platform:: GPL570
Series:: GSE21550
12 Samples

Download data: CEL

DataSet

Accession:: GDS4172

ID:: 4172

Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:: Homo sapiens

602 DataSets
5669 Series
61 Related Platforms
174561 Samples

Platform

Accession:: GPL570

ID:: 100000570

Select item 3005386184.

U937 transfected with GFP-PR2VR, 9 hours post infection, replicate 2

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538618

ID:: 300538618

Select item 3005386175.

U937 transfected with GFP-PRWT,9 hours post infection, replicate 2

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538617

ID:: 300538617

Select item 3005386166.

U937 transfected with control GFP, 9 hours post transfection, replicate 2

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538616

ID:: 300538616

Select item 3005386157.

U937 transfected with GFP-PR2VR, 6 hours post infection, replicate 2

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538615

ID:: 300538615

Select item 3005386148.

U937 transfected with GFP-PRWT,6 hours post infection, replicate 2

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538614

ID:: 300538614

Select item 3005386139.

U937 transfected with control GFP, 6 hours post transfection, replicate 2

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538613

ID:: 300538613

Select item 30053861210.

U937 transfected with GFP-PR2VR, 6 hours post infection, replicate 1

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538612

ID:: 300538612

Select item 30053861111.

U937 transfected with GFP-PRWT,6 hours post infection, replicate 1

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538611

ID:: 300538611

Select item 30053861012.

U937 transfected with control GFP, 6 hours post transfection, replicate 1

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538610

ID:: 300538610

Select item 30053860913.

U937 transfected with GFP-PR2VR, 9 hours post infection, replicate 1

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538609

ID:: 300538609

Select item 30053860814.

U937 transfected with GFP-PRWT,9 hours post infection, replicate 1

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538608

ID:: 300538608

Select item 30053860715.

U937 transfected with control GFP, 9 hours post transfection, replicate 1

Organism:: Homo sapiens

Source name:: U937 cell line

Platform:: GPL570
Series:: GSE21550
Dataset:: GDS4172

Download data: CEL

Sample

Accession:: GSM538607

ID:: 300538607

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