GSE6505[Accession] - GEO DataSets

Select item 2000065051.

Tumor suppression by Interferon regulatory factor-1 relies on down-regulation of cyclin D1

(Submitter supplied) Interferons have been ascribed to mediate antitumor effects. IRF-1 is a major target gene of interferons. It inhibits cell proliferation and oncogenic transformation. Here we show that 60% of all mRNAs deregulated by oncogenic transformation mediated by c-myc and H-ras are reverted to the expression levels of non-transformed cells by IRF-1. These include cell cycle regulating genes. Activation of IRF-1 decreases cyclin D1 expression and CDK4 kinase activity concomitant with dephosphorylation of pRb. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2752
Platform:: GPL81
6 Samples

Download data: CEL

Series

Accession:: GSE6505

ID:: 200006505

Select item 27522.

Interferon regulatory factor-1 effect on transformed cells

Analysis of myc/ras transformed cells expressing interferon regulatory factor-1 (IRF-1). IRF-1 mediates proliferation inhibition and reversion of the transformed phenotype of oncogenic cells. Results provide insight into the molecular alterations initiated by the action of IRF-1.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 cell type, 2 protocol sets

Platform:: GPL81
Series:: GSE6505
6 Samples

Download data: CEL

DataSet

Accession:: GDS2752

ID:: 2752

Select item 1000000813.

[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The MG-U74 set includes 3 arrays with a total of 36899 entries and was indexed 29-Jan-2002. more...